Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis

Publication date: Available online 6 February 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Rachel R Huxley , Sanne A E Peters , Gita D Mishra , Mark Woodward Background Studies have suggested sex differences in the mortality rate associated with type 1 diabetes. We did a meta-analysis to provide reliable estimates of any sex differences in the effect of type 1 diabetes on risk of all-cause mortality and cause-specific outcomes. Methods We systematically searched PubMed for studies published between Jan 1, 1966, and Nov 26, 2014. Selected studies reported sex-specific estimates of the standardised mortality ratio (SMR) or hazard ratios associated with type 1 diabetes, either for all-cause mortality or cause-specific outcomes. We used random effects meta-analyses with inverse variance weighting to obtain sex-specific SMRs and their pooled ratio (women to men) for all-cause mortality, for mortality from cardiovascular disease, renal disease, cancer, the combined outcome of accident and suicide, and from incident coronary heart disease and stroke associated with type 1 diabetes. Findings Data from 26 studies including 214 114 individuals and 15 273 events were included. The pooled women-to-men ratio of the SMR for all-cause mortality was 1·37 (95% CI 1·21–1·56), for incident stroke 1·37 (1·03–1·81), for fatal renal disease 1·44 (1·02–2·05), and for fatal cardiovascular diseases 1·86 (1·62–2·15). For incident coronary heart...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research