Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR

This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findings led to the concept of fetal adaptation to prenatal environmental changes and vulnerability to chronic diseases in adult life, a concept known as “fetal programming.” In 2003, the concept of “Developmental origins of health and disease (DOHaD)” was published (25). DOHaD describes the scenario whereby in utero maternal insults result in structural and functional changes in fetal organs extending in postnatal life and increasing susceptibility of chronic disease in adulthood. Fetal programming of other organs such as the brain (19), lungs (26), and hypothalamic-pituitary-adrenal (HPA) axis have been greatly studied, however the heart is also very important and few studies have investigated fetal programming of the heart as summarized below (27). Fetal Programming of the Heart in IUGR The heart is the first organ to develop and funct...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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ConclusionAccording to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets and links.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Publication date: Available online 20 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Lucía Matute-Blanco, Pablo Pastor Pueyo, Kristian Rivera
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 20 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Antonia Sambola, Ana Viana Tejedor, Pilar Jiménez-Quevedo, Fernando Alfonso
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
This study sought to analyze the association of early coronary angiography with all-cause mortality and cardiovascular mortality in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS) using a large contemporary cohort of patients with NSTEACS from 2 Spanish tertiary hospitals.MethodsThis retrospective observational study included 5673 consecutive NSTEACS patients from 2 Spanish hospitals between 2005 and 2016. We performed propensity score matching to obtain a well-balanced subset of patients with the same probability of undergoing an early strategy, resulting in 3780 patients. Survival analyses ...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 21 May 2019Source: Journal of the Saudi Heart AssociationAuthor(s): Waleed AlHabeeb, Fakhr Al-Ayoubi, Kamal AIGhalayini, Fahad Al Ghofaili, Yahya Al Hebaishi, Abdulrazaq Al-Jazairi, Mouaz H. Al-Mallah, Ali AlMasood, Maryam Al Qaseer, Shukri Al-Saif, Ammar Chaudhary, Abdelfatah Elasfar, Adel TashAbstractHeart failure (HF) is the leading cause of morbidity and mortality worldwide and negatively impacts quality of life, healthcare costs, and longevity. Although data on HF in the Arab population is scarce, recently developed regional registries are a step forward to evaluating the quality of ...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
This study recruited 498 STEMI patients post percutaneous coronary intervention (PCI), 40 with stable angina pectoris (SAP) and 137 healthy participants. Plasma MIF levels were measured at admission and after PCI. The primary endpoints were in-hospital mortality and major adverse cardio- and/or cerebro-vascular events (MACE/MACCE) during hospitalization and 3.2-year follow-up period.ResultsAdmission MIF levels were elevated in 88.4% STEMI patients over the upper reference limit of healthy controls and it was 3-7 folds higher than that in SAP and control groups (122±61 vs. 39±19 vs. 17±8 ng/mL, P
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 20 May 2019Source: Canadian Journal of CardiologyAuthor(s): Hung Q. Ly, Mohamed Nosair, Raymond CartierABSTRACTOptimal revascularization in severe ischemic heart disease (SIHD) is addressed in all clinical guidelines. With an aging patient population, a growing challenge remains the management of SIHD patients deemed ineligible for surgical revascularization, the so-called surgical turndown patient. The status of surgical ineligibility remains associated with worse clinical outcomes. As the general population grows older and comorbidities increase, this subset of SIHD will likely increase...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This study aimed to assess survival after TARE and to identify potential prognostic factors in this patient population. METHODS: Patients with unresectable and chemorefractory CRCLM treated with TARE at our institution between February 2006 and September 2015 were included in the study. Survival rate, hepatic tumor response, and potential prognostic factors were analyzed. RESULTS: In the 43 study patients, the mean follow-up was 15.0 ± 14.2 months, with a median survival of 13.0 months and 1-, 2-, 3-, 4-, and 5-year survival rates of 52.1%, 24.9%, 21.4%, 21.4%, and 7.1%, respectively. The mean activity of yt...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Authors: Ballestri S, Nascimbeni F, Lugari S, Lonardo A, Francica G Abstract INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). NAFLD carries an increased risk of cardio-metabolic and liver-related events accounting for a substantial economic burden. Given that the natural history of NAFLD is critically dependent on the stage of fibrosis, non-invasively identifying the subgroup of patients at a higher risk of progressive disease is key. Areas covered: This review highlights the recent development...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
CONCLUSION: WFRP is fast and effective in screening for diabetic retinopathy. The severity grade of the disease was similar to the gold standard of FRP in most cases. WFRP could thus be used in mass screening for diabetic retinopathy. PMID: 31104875 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
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