Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR

This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findings led to the concept of fetal adaptation to prenatal environmental changes and vulnerability to chronic diseases in adult life, a concept known as “fetal programming.” In 2003, the concept of “Developmental origins of health and disease (DOHaD)” was published (25). DOHaD describes the scenario whereby in utero maternal insults result in structural and functional changes in fetal organs extending in postnatal life and increasing susceptibility of chronic disease in adulthood. Fetal programming of other organs such as the brain (19), lungs (26), and hypothalamic-pituitary-adrenal (HPA) axis have been greatly studied, however the heart is also very important and few studies have investigated fetal programming of the heart as summarized below (27). Fetal Programming of the Heart in IUGR The heart is the first organ to develop and funct...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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This study investigates the distribution of femoral metastases in cancer patients, specifically addressing the incidence of distal femoral metastases. PET/CT examinations routinely extend only to mid-thigh level, precluding detection of distal metastases. We found a total of 208 femoral metastases in 112 patients. 30% had distal femoral metastases in addition to other areas of involvement. 7% of patients with femoral metastases had only distal femur disease. 6 patients had distal pathologic fractures. Exclusion of the distal femur during PET/CT may result in a missed or delayed diagnosis that could contribute to the develo...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Authors: Xu H, Dong L, Bin Z, Yansong H, Shaofeng L, Chang L, Chen C, Changli W Abstract Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
To compare the outcomes of laparoscopic retroperitoneal hysterectomy (LRH) in morbidly obese patients (BMI ≥ 40 k/m2) versus non-obese patients (BMI
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
To assess factors and charges associated with hospital revisits following benign hysterectomy in the United States.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
Malpositioned intrauterine devices (IUDs) are identified in 20% of women undergoing pelvic ultrasound (US) for gynecologic indication and may necessitate surgical intervention for removal; this study evaluates whether US-guided IUD insertion decreases malposition and discontinuation rates compared to the traditional blind method of insertion.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
To compare the outcomes of laparoscopic-assisted myomectomy (LAM) in morbidly obese patients (BMI ≥ 40 k/m2) versus non-obese patients (BMI
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
The objective of this study is to determine the value of Doppler flow ultrasound imaging in the preoperative evaluation of the patient with clinical suspicion of ovarian torsion.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
To identify the independent risk factors of concurrent endometrial cancer among women with endometrial hyperplasia and build the clinical prediction model incorporating the clinical and pathological markers.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a rare single spectrum of severe epidermolytic reactions that can involve the vulva, vagina, and cervix. Description of specific management techniques for vulvovaginal SJS/TEN in the literature is sparse. This is a retrospective review of women treated at  a tertiary care burn center for SJS/TEN with vulvovaginal involvement.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
To assess the effects of site and route of morcellation on perioperative outcomes in patients with body mass index (BMI) ≥40 (WHO class 3 obesity).
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
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