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Condition: Pulmonary Hypertension

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Total 621 results found since Jan 2013.

Modeling the public health impact of voxelotor in the management of sickle cell disease in France
The objective of this study was to estimate the impact of voxelotor on the burden of SCD in France using a modeling approach, accounting for its anticipated adoption and diffusion over the next 5 years. We designed a sequential multi-cohort model to project and compare the cumulative incidence of SCD complications over a 20-year time horizon in a world with and without voxelotor. A distribution of patients was simulated across various levels of Hb response based on the phase 3 HO PE trial results, and relative risk reduction was adjusted using published meta-analysis results that projected risk reduction due to a 1 g/dL in...
Source: PLoS One - September 13, 2023 Category: Biomedical Science Authors: Fr édéric Galacteros Source Type: research

Trends in cardiovascular complications of pregnancy: A nationwide inpatient sample analysis
CONCLUSION: There are concerning increases in certain cardiac complications during pregnancy. This is likely due to increasing age at the time of pregnancy and associated comorbidities.PMID:37678669 | DOI:10.1016/j.amjms.2023.09.001
Source: The American Journal of the Medical Sciences - September 7, 2023 Category: General Medicine Authors: Eric D Warner Saaniya Farhan Matthew Bierowski Farhan Sahawneh Estefania Oliveros Preethi Pirlamarla Stefanie Marek-Iannucci Bhavadharini Ramu Waqas Ullah Yevgeniy Brailovsky Indranee N Rajapreyar Source Type: research

Trends in cardiovascular complications of pregnancy: A Nationwide Inpatient Sample analysis: Trends in cardiovascular complications of pregnancy
CONCLUSION: There are concerning increases in certain cardiac complications during pregnancy. This is likely due to increasing age at the time of pregnancy and associated comorbidities.PMID:37678669 | DOI:10.1016/j.amjms.2023.09.001
Source: The American Journal of the Medical Sciences - September 7, 2023 Category: General Medicine Authors: Eric D Warner Saaniya Farhan Matthew Bierowski Farhan Sahawneh Estefania Oliveros Preethi Pirlamarla Stefanie Marek-Iannucci Bhavadharini Ramu Waqas Ullah Yevgeniy Brailovsky Indranee N Rajapreyar Source Type: research

Associations between eGFR and albuminuria with right ventricular measures: the MESA-Right Ventricle study
CONCLUSIONS: Among community-dwelling adults, reductions in eGFR primarily within the normal range were associated with smaller RV volumes and the association of albuminuria with worse survival was stronger among those with smaller RV volumes. Further studies are needed to elucidate the underlying mechanistic pathways that link kidney measures and RV morphology.PMID:37664568 | PMC:PMC10469092 | DOI:10.1093/ckj/sfad096
Source: Atherosclerosis - September 4, 2023 Category: Cardiology Authors: Faeq Husain-Syed Matthew F DiFrancesco Rajat Deo R Graham Barr Julia J Scialla David A Bluemke Richard A Kronmal Joao A C Lima Amy Praestgaard Russell P Tracy Michael Shlipak Steven M Kawut John S Kim Source Type: research

Towards the implementation of optimal cardiac magnetic resonance risk stratification in PAH
Chest. 2023 Jul 30:S0012-3692(23)01066-8. doi: 10.1016/j.chest.2023.07.028. Online ahead of print.ABSTRACTBACKGROUND: The 2022 European pulmonary hypertension (PH) guidelines incorporate cardiac magnetic resonance (CMR) imaging metrics in the risk stratification of pulmonary arterial hypertension (PAH) patients. Thresholds to identify patients at estimated 1-year mortality risks of <5%, 5-20% and >20% are introduced. However, these cut-off values are mostly single center based and require external validation.RESEARCH QUESTIONS: What are the discriminative prognostic properties of the current cardiac magnetic resonanc...
Source: Chest - August 1, 2023 Category: Respiratory Medicine Authors: L R Celant J N Wessels J T Marcus L J Meijboom H J Bogaard F S de Man A Vonk Noordegraaf Source Type: research

Pulmonary hypertension: An unexplored risk factor for stroke in patients with atrial fibrillation
Atrial fibrillation (Afib) is one of the most common and significant risk factors for stroke, with the CHADsVAsc score used as the tool for stroke risk assessment. Pulmonary hypertension (PH) has not been studied as an independent risk factor for stroke in individuals with Afib.
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2023 Category: Neurology Authors: Georges Khattar, Ahmad Mustafa, Fasih Sami Siddiqui, Khalil El Gharib, Wei Chapman, Saif Abu Baker, Saud Bin Abdul Sattar, Dany Elsayegh, Halim El-Hage, Suzanne El Sayegh, Michel Chalhoub Source Type: research

The Right Ventricle in Pulmonary Hypertension
Semin Respir Crit Care Med. 2023 Jul 24. doi: 10.1055/s-0043-1770117. Online ahead of print.ABSTRACTThe right ventricle plays a pivotal role in patients with pulmonary hypertension (PH). Its adaptation to pressure overload determines a patient's functional status as well as survival. In a healthy situation, the right ventricle is part of a low pressure, high compliance system. It is built to accommodate changes in preload, but not very well suited for dealing with pressure overload. In PH, right ventricular (RV) contractility must increase to maintain cardiac output. In other words, the balance between the degree of RV con...
Source: Respiratory Care - July 24, 2023 Category: Respiratory Medicine Authors: Jeroen N Wessels Lucas R Celant Frances S de Man Anton Vonk Noordegraaf Source Type: research

Echocardiographic pressure –strain loop‐derived stroke work of the right ventricle: validation against the gold standard
ConclusionsIntegrated echo measurement of pressure –strain loop-derived SW correlates with PV loop-based assessment of RV SW. Wasted work correlates with invasive measures of load-independent RV function. Given the methodological and anatomical challenges of RV work assessment, evolution of this approach by incorporating more elaborated echo analy sis data and an RV reference curve might improve its reliability to mirror invasively assessed RV SW.
Source: ESC Heart Failure - July 7, 2023 Category: Cardiology Authors: Manuel J. Richter, Philipp Douschan, Federico Fortuni, Henning Gall, Hossein A. Ghofrani, Stanislav Keranov, Nils Kremer, Steffen D. Kriechbaum, Zvonimir A. Rako, Andreas J. Rieth, Bruno Brito Rocha, Werner Seeger, Daniel Zedler, Selin Yildiz Tags: Short Communication Source Type: research

Syncope Evaluation: Evidence-Based and Economical
This study eliminated low-risk syncope patients and those with non-syncope transient loss of consciousness, such as seizure and head trauma, using a structured approach in the emergency department (ED), with only high-risk syncope patients being admitted. These high-risk syncope patients made up 28% of the patients included in the study. After admission, a simplified Wells’ pulmonary embolism criteria score was calculated, and a D-dimer was obtained. If either was high, the patient was scanned for PE and 17% were found to be positive, with two-thirds of those being found to have large-vessel pulmonary emboli. The bottom ...
Source: The Hospitalist - July 5, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Source Type: research

Chronic myeloid leukemia, tyrosine kinase inhibitors and cardiovascular system
CONCLUSIONS: The current CML treatment target is a cure that leads to normal age and gender-adjusted survival with a "normal" quality of life. Cardiovascular disorders are one of the major obstacles to reaching this target in CML patients. The treatment choices for CML patients must include a cardiovascular perspective.PMID:37401285 | DOI:10.26355/eurrev_202306_32786
Source: Pharmacological Reviews - July 4, 2023 Category: Drugs & Pharmacology Authors: U Y Malkan I C Haznedaroglu Source Type: research