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Condition: Pulmonary Hypertension
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Total 621 results found since Jan 2013.
Echocardiographic Biventricular Coupling Index to Predict Pre-Capillary Pulmonary Hypertension
In this study, the novel echocardiographic Biventricular Coupling Index (BCI), based on the ratio between Right Ventricular Stroke Work Index and left ventricular E/E ’ ratio, was tested for the discrimination of PH subtype using RHC as the comparator.
Source: Journal of the American Society of Echocardiography - February 10, 2022 Category: Cardiology Authors: Stefano Albani, Davide Stolfo, Ashwin Venkateshvaran, Vlad Chubuchny, Federico Biondi, Antonio De Luca, Francesco Lo Giudice, Emilio M. Pasanisi, Christina Petersen, Edoardo Air ò, Carolina Bauleo, Marco Ciardetti, Michele Coceani, Bruno Formichi, Jens S Tags: Clinical Investigations Source Type: research
Echocardiographic Biventricular Coupling Index to Predict Precapillary Pulmonary Hypertension
In this study, the novel echocardiographic biventricular coupling index (BCI), based on the ratio between right ventricular stroke work index and left ventricular E/E ′ ratio, was tested for the discrimination of PH subtype using RHC as the comparator.
Source: Journal of the American Society of Echocardiography - February 10, 2022 Category: Cardiology Authors: Stefano Albani, Davide Stolfo, Ashwin Venkateshvaran, Vlad Chubuchny, Federico Biondi, Antonio De Luca, Francesco Lo Giudice, Emilio M. Pasanisi, Christina Petersen, Edoardo Air ò, Carolina Bauleo, Marco Ciardetti, Michele Coceani, Bruno Formichi, Jens S Source Type: research
Janssen Data at ASCO GU Demonstrate Longstanding Leadership in Prostate Cancer and Commitment to Advancing Potential New Therapeutic Options for Genitourinary Cancers
Raritan, NJ, Feb. 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that 17 presentations will be featured at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place in San Francisco and virtually from February 17-19. Building on its long-term leadership in prostate cancer, Janssen is committed to advancing innovative treatments and transforming patient experiences, while focusing on research that may drive better outcomes for people across the genitourinary cancer spectrum. Data to be presented include Phase 3 results for the selective ...
Source: Johnson and Johnson - February 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Incremental prognostic value of arterial elastance in mild-to-moderate idiopathic pulmonary fibrosis
AbstractPrevious reports suggested that poor pulmonary function was associated with increased arterial elastance (Ea) in patients with chronic obstructive pulmonary disease and systemic sclerosis. The mechanisms connecting pulmonary function and Ea have not yet been accurately studied in patients with idiopathic pulmonary fibrosis (IPF). The present study was designed to assess Ea in IPF patients without chronic severe pulmonary hypertension and to determine its prognostic role over a medium-term follow-up. This retrospective study included 60 consecutive patients with mild-to-moderate IPF (73.8 ± 6.6 years, 75% mal...
Source: The International Journal of Cardiovascular Imaging - February 1, 2022 Category: Radiology Source Type: research
Left atrium reservoir function is central in patients with rheumatic mitral stenosis
We examined 195 full spectrum MS patients which were divided into two groups: Group 1 (n = 109) included patients with NYHA I& II functional class and group 2 (n = 86) included patients with NYHA III& IV functional class. LA strain reservoir function and classical echocardiographic parameters were calculated. LASr was significantly higher in group 1 versus group 2 in patients with MVA ≤ 1cm2 [8.8(6.0 –12.6) vs 6.8(4.1–8.9),p = 0.03) and when 1cm2 < MVA ≤ 1.5 cm2 [10.0 (5.4 –13.8) vs 6.7(4.5–9.0),p = 0.02). In patients with Pulmonary Hypertension, group 1 had significantl...
Source: The International Journal of Cardiovascular Imaging - December 31, 2021 Category: Radiology Source Type: research
Research advances of occludin in vascular endothelial injury
Sheng Li Xue Bao. 2021 Dec 25;73(6):931-939.ABSTRACTEndothelial tight junctions (TJs) serve as an important barrier in vascular endothelial structure and maintain vascular function homeostasis. Occludin, the most representative tight junction protein, is involved in sealing cell connections and maintaining the integrity and permeability of vascular endothelium. Recent studies have shown that alterations in the expression, distribution, and structure of endothelial TJs may lead to many related vascular diseases and pathologies (such as stroke, atherosclerosis, and pulmonary hypertension etc.). Here, we reviewed the research...
Source: Atherosclerosis - December 28, 2021 Category: Cardiology Authors: Yan-Ru Duan Yun-Hui DU Hui-Rong Liu Source Type: research
FDA Approves Two New Indications for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, Dec. 20, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved two pediatric indications for XARELTO® (rivaroxaban): the treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients from birth to less than 18 years after at least five days of initial parenteral (injected or intravenous) anticoagulant treatment; and thromboprophylaxis (prevention of blood clots and blood-clot related events) in children aged two years and older with congenital heart disease who have...
Source: Johnson and Johnson - December 21, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
A fully automated cardiac magnetic resonance (CMR) assessment improves the evaluation of patients with pulmonary arterial hypertension (PAH)
Conclusion: In a prospective PAH cohort, fully automatic CMR assessments were reliable and corresponded accurately to invasive hemodynamics
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Alabed, S., Karunasaagarar, K., Alandejani, F., Salehi, M., Aldabbagh, Z., Garg, P., Uthoff, J., Lu, H., Wild, J., Kiely, D., Van Der Geest, R., Swift, A. Tags: Imaging Source Type: research
Low-dose thrombolysis for submassive pulmonary embolism
This study aimed to evaluate the role of half-dose tissue-type plasminogen activator (rt-PA) in preventing death/hemodynamic decompensation in submassive (intermediate-risk) PE without increasing the risk of bleeding. In a prospective, non-randomized, open-label, single-center trial, we compared 50 mg rt-PA plus low molecular weight heparin (LMWH) with LMWH in submassive (intermediate-risk) PE. Eligible cases had confirmed pulmonary hypertension on echocardiography, and/or right ventricular cavity expansion and/or interventricular septal deviation on echocardiography, and/or right to left ventricular ratio equal to or grea...
Source: Journal of Investigative Medicine - November 25, 2021 Category: Research Authors: Yilmaz, E. S., Uzun, O. Tags: Open access Original research Source Type: research
Controversies over the impact of the COVID-19 pandemic on patients with Pulmonary Arterial Hypertension
This study is a retrospective analysis of our PAH patients treated in 2020 compared to the dynamics of the last 12 years. We had 48 PAH patients, 51.72±16.64 years, 72.91% female. All patients had chronic anticoagulant therapy(58.33%) and/or antiplatelet; 33.33% had long term oxygen therapy. Three patients with secondary forms were confirmed with COVID-19, all hospitalized (6.25% infection rate versus 3.29% in general). One patient died(75 years with scleroderma, stroke), two patients were cured (mild forms). In total only three patients died in 2020. Surprisingly, compared with 2008-2019 (101 patients/ 41 deaths, 3...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Bertici, N. S., Dobrescu, L., Pislaru, L., Marincu, I. Tags: Pulmonary hypertension Source Type: research
Patient-Specific Computational Analysis of Hemodynamics in Adult Pulmonary Hypertension
Ann Biomed Eng. 2021 Nov 19. doi: 10.1007/s10439-021-02884-y. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a progressive disease characterized by elevated pressure and vascular resistance in the pulmonary arteries. Nearly 250,000 hospitalizations occur annually in the US with PH as the primary or secondary condition. A definitive diagnosis of PH requires right heart catheterization (RHC) in addition to a chest computed tomography, a walking test, and others. While RHC is the gold standard for diagnosing PH, it is invasive and posseses inherent risks and contraindications. In this work, we characterized the ...
Source: Annals of Biomedical Engineering - November 20, 2021 Category: Biomedical Engineering Authors: Narasimha R Pillalamarri Senol Piskin Sourav S Patnaik Srinivas Murali Ender A Finol Source Type: research
