Left atrium reservoir function is central in patients with rheumatic mitral stenosis

We examined 195 full spectrum MS patients which were divided into two groups: Group 1 (n = 109) included patients with NYHA I& II functional class and group 2 (n = 86) included patients with NYHA III& IV functional class. LA strain reservoir function and classical echocardiographic parameters were calculated. LASr was significantly higher in group 1 versus group 2 in patients with MVA  ≤ 1cm2 [8.8(6.0 –12.6) vs 6.8(4.1–8.9),p = 0.03) and when 1cm2 <  MVA ≤ 1.5 cm2 [10.0 (5.4 –13.8) vs 6.7(4.5–9.0),p = 0.02). In patients with Pulmonary Hypertension, group 1 had significantly higher LASr than group 2 [11.1(6.6–14.8) vs 5.9(4.3–9.0),p = 0.002) By multivariate analysis, diabetes (OR = 4.11, 95%CI: 1.6–10.4), stroke (OR = 2.9, 95%CI: 1.1–7.9), LASr (OR = 0.9, 95%CI: 0.80–0.99) and LV ejection fraction (LVEF)(OR = 0.9, 95%CI: 0.91–0.99) were independently associated with NYHA functional class. LASr was s ignificantly and positively correlated to MVA (r = 0.3,p <  10–3), stroke volume (r  = 0.25,p = 10–3), mitral inflow (r  = 0.4,p <  10–3) and LVEF(r  = 0.14,p = 0.05). It was significantly and negatively correlated to left ventricular strain (r = −0.65,p <  10–3), LA indexed volume (r  = −0.40,p <  10–3), maximum tricuspid regurgitation velocity (r  = −0.25,p = 0.003), MTMG (r = −0.25,p = 10–3), and heart ...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research