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Condition: Pulmonary Hypertension

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Total 621 results found since Jan 2013.

Safety and Efficacy of the Transaxillary Access for Minimally Invasive Aortic Valve Surgery
Conclusions: Transaxillary MICS-AVR is at least as safe as AVR by sternotomy and can be performed in the same time frame. Its advantages are fewer transfusions and quicker postoperative recovery with a significantly shorter hospital stay. The cosmetic result and unrestricted physical abilities due to the untouched sternum and ribs are unique advantages of transaxillary access.PMID:36676784 | PMC:PMC9860976 | DOI:10.3390/medicina59010160
Source: Medicina (Kaunas) - January 21, 2023 Category: Universities & Medical Training Authors: Manuel Wilbring Konstantin Alexiou Torsten Schmidt Asen Petrov Ali Taghizadeh-Waghefi Efstratios Charitos Klaus Matschke Sebastian Arzt Utz Kappert Source Type: research

Sleep disordered breathing and its relation to stroke and pulmonary hypertension in children with sickle cell disease: a single-center cross-sectional study
AbstractSleep disordered breathing (SDB) is a common underdiagnosed sequela of sickle cell disease (SCD) that has been linked to the frequency of vaso-occlusive crises. To determine the frequency of SDB in children with SCD and its association to SCD-related complications, thirty children and adolescents with SCD at their steady state underwent clinical, laboratory, and radiological assessment using transcranial duplex (TCD) and echo assessment of tricuspid regurge velocity (TRV). All participants had an overnight polysomnography after completing the modified STOP-Bang questionnaire. The mean age of the studied cohort was ...
Source: Annals of Hematology - January 16, 2023 Category: Hematology Source Type: research

Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling
Biomed Res Int. 2022 Dec 24;2022:3959845. doi: 10.1155/2022/3959845. eCollection 2022.ABSTRACTVascular remodeling refers to changes in the size, contraction, distribution, and flow rate of blood vessels and even changes in vascular function. Vascular remodeling can cause cardiovascular and cerebrovascular diseases. It can also lead to other systemic diseases, such as pulmonary hypertension, pulmonary atherosclerosis, chronic obstructive pulmonary disease, stroke, and ascites of broilers. Hypoxia is one of the main causes of vascular remodeling. Prolonged hypoxia or intermittent hypoxia can lead to loss of lung ventilation,...
Source: Biomed Res - January 3, 2023 Category: Research Authors: Xiaojuan Huang Elif Ece Akg ün Khalid Mehmood Hui Zhang Zhaoxin Tang Ying Li Source Type: research

Real-World Study Confirms Benefit of XARELTO ® (rivaroxaban) for Secondary Prevention of Venous Thromboembolism in Cancer Patients
TITUSVILLE, NJ, December 9, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced observational data from eight years of clinical practice showing that the oral Factor Xa inhibitor XARELTO® (rivaroxaban) is associated with comparable effectiveness and safety to the Factor Xa inhibitor apixaban for the treatment of cancer-associated thromboembolism (CAT) in a broad cohort of patients with various cancer types. Patients with CAT are at a higher risk of venous thromboembolism (VTE), which is the second-leading cause of death in people with cancer.1Data from the Observational Study in Cancer-A...
Source: Johnson and Johnson - December 9, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news

Acute beat blockade improves right ventricular diastolic filling in pulmonary arterial hypertension: a rodent CMR and clinical human pressure-volume study
Conclusions: Esmolol improves RV diastolic filling in PAH at rest and during low-grade exercise, preserving SV and CO, with energetically favourable effects on contractile efficiency.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Samaranayake, C., Niglas, M., Kempny, A., Baxan, N., Ashek, A., Pinguel, J., Dimopoulos, K., Price, L. C., Wort, S. J., Zhao, L., Mccabe, C. Tags: 13.01 - Pulmonary hypertension Source Type: research

Adaptive versus maladaptive right ventricular remodelling
AbstractRight ventricular (RV) function and its adaptation to increased afterload [RV –pulmonary arterial (PA) coupling] are crucial in various types of pulmonary hypertension, determining symptomatology and outcome. In the course of disease progression and increasing afterload, the right ventricle undergoes adaptive remodelling to maintain right-sided cardiac output by increasing contractility. Exhaustion of compensatory RV remodelling (RV–PA uncoupling) finally leads to maladaptation and increase of cardiac volumes, resulting in heart failure. The gold-standard measurement of RV–PA coupling is the ratio of contract...
Source: ESC Heart Failure - November 24, 2022 Category: Cardiology Authors: Zvonimir A. Rako, Nils Kremer, Athiththan Yogeswaran, Manuel J. Richter, Khodr Tello Tags: Review Source Type: research