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Condition: Pulmonary Hypertension
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Total 621 results found since Jan 2013.
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog Basic Sciences
Conclusions—Our data suggest that targeting the IP receptor with MRE-269 is a novel strategy to reduce cerebral ischemia injury and promote long-term neurological recovery in ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Changjun Yang, Kelly M. DeMars, Jon C. Alexander, Marcelo Febo, Eduardo Candelario-Jalil Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research
Association of Transthoracic Echocardiography Findings and Long-Term Outcomes in Patients Undergoing Workup of Stroke
Transthoracic echocardiography (TTE) has become routine as part of initial stroke workup to assess for sources of emboli. Few studies have looked at other TTE findings such as ejection fraction, wall motion abnormalities, valve disease, pulmonary hypertension and left ventricular hypertrophy and their association with various subtypes of stroke, long-term outcomes of recurrent stroke, and all-cause mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - July 30, 2018 Category: Neurology Authors: Jeremy A. Miles, Leonid Garber, Subha Ghosh, Daniel M. Spevack Source Type: research
Pulmonary hypertension: An unexplored risk factor for stroke in patients with atrial fibrillation
Atrial fibrillation (Afib) is one of the most common and significant risk factors for stroke, with the CHADsVAsc score used as the tool for stroke risk assessment. Pulmonary hypertension (PH) has not been studied as an independent risk factor for stroke in individuals with Afib.
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2023 Category: Neurology Authors: Georges Khattar, Ahmad Mustafa, Fasih Sami Siddiqui, Khalil El Gharib, Wei Chapman, Saif Abu Baker, Saud Bin Abdul Sattar, Dany Elsayegh, Halim El-Hage, Suzanne El Sayegh, Michel Chalhoub Source Type: research
Milvexian Granted U.S. FDA Fast Track Designation for All Three Indications Under Evaluation in Phase 3 Librexia Program: Ischemic Stroke, Acute Coronary Syndrome and Atrial Fibrillation
RARITAN, NJ, May 25, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that all three prospective indications for milvexian, an investigational oral factor XIa (FXIa) inhibitor (being developed in collaboration with Bristol Myers Squibb), have now been granted Fast Track Designation by the U.S. Food and Drug Administration (FDA). The designations cover all three indication-seeking studies within the Phase 3 Librexia development program (Librexia STROKE, Librexia ACS and Librexia AF), which are all dosing patients. The Librexia program is unrivaled as the most comprehensive FXIa clinical...
Source: Johnson and Johnson - May 25, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Factors relating to impaired stroke volume during the 6-minute walk test in patients with systemic sclerosis.
CONCLUSIONS: Impaired stroke volume in patients with systemic sclerosis was observed at rest and during exercise, and the factors relating to the cardiac response seemed to be pulmonary function and the extent of pulmonary hypertension.
PMID: 27463117 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - July 28, 2016 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Johnson & Johnson Launches Heartline ™, the First-of-its-Kind, Virtual Study Designed to Explore if a New iPhone App and Apple Watch Can Help Reduce the Risk of Stroke
New Brunswick, NJ, February 25, 2020 — Johnson & Johnson (NYSE: JNJ) today announced that the Janssen Pharmaceutical Companies of Johnson & Johnson, in collaboration with Apple, opened enrollment for the Heartline™ Study. The study is designed to explore if the Heartline™ Study app on iPhone and heart health features on Apple Watch can improve health outcomes, including reducing the risk of stroke, with earlier detection of atrial fibrillation (AFib). AFib, a common form of irregular heart rhythm, is a leading cause of stroke in the U.S. To enroll in the Heartline™ Study, individuals must be age 65 or older...
Source: Johnson and Johnson - February 25, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
Effect of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension on Stroke Volume Response to Exercise
In pulmonary hypertension, exercise is limited by an impaired right ventricular (RV) stroke volume response. We hypothesized that improvement in exercise capacity after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) is paralleled by an improved RV stroke volume response. We studied the extent of PEA-induced restoration of RV stroke volume index (SVI) response to exercise using cardiac magnetic resonance imaging (cMRI). Patients with CTEPH (n = 18) and 7 healthy volunteers were included. Cardiopulmonary exercise testing and cMRI were performed before and 1 year after PEA. For cMRI ...
Source: The American Journal of Cardiology - April 21, 2014 Category: Cardiology Authors: Sulaiman Surie, Mart N. van der Plas, J. Tim Marcus, Taco Kind, Jaap J. Kloek, Anton Vonk-Noordegraaf, Paul Bresser Tags: Miscellaneous Source Type: research
A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.
Authors: Mustafa ER, Tudoraşcu DR, Giucă A, Toader DM, Foarfă MC, Puiu I, Istrate-Ofiţeru AM
Abstract
A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosi...
Source: Romanian Journal of Morphology and Embryology - December 13, 2018 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Cyanosis and Stroke due to Functional Cor Triatriatum Dexter in a Neonate.
Abstract
Small remnants of the right valve of the sinus venosus are commonly found in adults, but the incidence and risk associated with these embryonic remnants in neonates are not well studied. The following report describes a cyanotic neonate with a large Eustachian valve remnant creating a functional cor triatriatum dexter who was initially diagnosed with persistent pulmonary hypertension of the newborn. The cyanosis in this infant improved over the first postnatal week with conservative management, but she suffered multifocal subcortical stroke, likely related to her intracardiac shunt. The clinical presentat...
Source: Neonatology - January 10, 2018 Category: Perinatology & Neonatology Authors: León RL, Zaban NB, Schamberger MS, Ho CY, Mietzsch U Tags: Neonatology Source Type: research
High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction
Conclusion: High right ventricular workload indicated by high RVSWI is associated with worse renal function in patients with Cpc-PH. Further prospective studies are needed to better understand this association.Cardiorenal Med 2018;8:123 –129
Source: Cardiorenal Medicine - February 28, 2018 Category: Urology & Nephrology Source Type: research
Right Ventricular Stroke Work Index.
In conclusion, lower RVSWI was significantly associated with HF death or HF readmission in patients with PAH or CTEPH.
PMID: 30101854 [PubMed - as supplied by publisher]
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research
Parameters of Right Ventricular Function Reveal Ventricular-Vascular Mismatch as Determined by Right Ventricular Stroke Work versus Pulmonary Vascular Resistance in Children with Pulmonary Hypertension
Right ventricular (RV) failure, a determinant of outcomes in pulmonary hypertension (PH), occurs when the right ventricle cannot compensate for increased afterload. The authors showed that RV stroke work (RVSW) can be estimated in children with PH as the product of stroke volume and RV pressure and is related to adverse outcomes. The aim of this study was to test the hypothesis that ventricular-vascular (VV) mismatch (high afterload and low RVSW) is associated with echocardiographic measures of RV performance and adverse outcomes.
Source: Journal of the American Society of Echocardiography - December 9, 2019 Category: Cardiology Authors: Michael V. Di Maria, Kristen R. Campbell, Dale A. Burkett, Adel K. Younoszai, Bruce F. Landeck, Luc Mertens, D. Dunbar Ivy, Kendall S. Hunter, Mark K. Friedberg Source Type: research
In reply: Stroke in pulmonary hypertension: Is it predictable or preventable?
We thank Wang et al. for their comments and for bringing forward the challenges in managing care of patients with pulmonary hypertension (PH) and stroke. We acknowledge multiple possible mechanisms of stroke in patients with PH, and we highlighted them in our work, including paradoxical emboli and atrial fibrillation [1]. However, polycythemia (increased red cells) or other myeloproliferative disorders are considered to be a cause and not a consequence of PH [2,3]. In mice models, Sala et al. have showed that chronic hypoxia could lead to both PH and polycythemia [4].
Source: International Journal of Cardiology - December 11, 2019 Category: Cardiology Authors: Trushil G. Shah, Jaini M. Sutaria, Manav V. Vyas Tags: Letter to the Editor Source Type: research
The association between pulmonary hypertension and stroke: a systematic review and meta-analysis
We thank Wang et al. for their comments and for bringing forward the challenges in managing care of patients with pulmonary hypertension (PH) and stroke. We acknowledge multiple possible mechanisms of stroke in patients with PH, and we highlighted them in our work, including paradoxical emboli and atrial fibrillation [1]. However, polycythemia (increased red cells) or other myeloproliferative disorders are considered to be a cause and not a consequence of PH [2,3]. In mice models, Sala et al. have showed that chronic hypoxia could lead to both PH and polycythemia [4].
Source: International Journal of Cardiology - December 11, 2019 Category: Cardiology Authors: Trushil G. Shah, Jaini M. Sutaria, Manav V. Vyas Tags: Letter to the Editor Source Type: research
High pulmonary vascular resistance in addition to low right ventricular stroke work index effectively predicts biventricular assist device requirement
In conclusion, high PVR in addition to low RVSWI effectively predicts BiVAD requirement.
Source: Journal of Artificial Organs - September 22, 2015 Category: Transplant Surgery Source Type: research
