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Condition: Pulmonary Hypertension
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Total 621 results found since Jan 2013.
Early Pulmonary Vascular Disease in Young Adults Born Preterm.
CONCLUSION: Young adults born preterm demonstrate early pulmonary vascular disease, characterized by elevated pulmonary pressures, a stiffer pulmonary vascular bed, and right ventricular dysfunction, consistent with an increased risk of developing pulmonary hypertension.
PMID: 29944842 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 26, 2018 Category: Respiratory Medicine Authors: Goss KN, Beshish AG, Barton GP, Haraldsdottir K, Levin TS, Tetri LH, Battiola TJ, Mulchrone AM, Pegelow DF, Palta M, Lamers LJ, Watson AM, Chesler NC, Eldridge MW Tags: Am J Respir Crit Care Med Source Type: research
Effects of Riociguat on Right Ventricular Remodeling in Chronic Thromboembolic Pulmonary Hypertension Patients: A Prospective Study
ConclusionsRiociguat treatment was associated with increased RVSVI and trends for improvement in myocardial remodeling in CTEPH patients. A larger clinical study is warranted to observe the therapeutic benefits of riociguat on RV remodeling.
Source: Canadian Journal of Cardiology - July 5, 2018 Category: Cardiology Source Type: research
Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients
ConclusionsHigh blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and ST were predictors of clinically apparent/silent brain infarction.
Source: Cor et Vasa - July 5, 2018 Category: Cardiology Source Type: research
MRI-derived Regional Biventricular Function in Patients with Chronic Thromboembolic Pulmonary Hypertension Before and After Pulmonary Endarterectomy
ConclusionWhile biventricular resynchronization and recovery of global predominantly RV function was observed, regional circumferential function mainly improved in the lateral and inferior walls of both ventricles and regional radial function in the RV wall and septum 12 days after PEA, suggesting fibers primarily affected by myocardial stress in patients with CTEPH possibly need a relatively longer recovery time.
Source: Academic Radiology - July 5, 2018 Category: Radiology Source Type: research
Effects of Riociguat on Right Ventricular Remodeling in Chronic Thromboembolic Pulmonary Hypertension Patients: A Prospective Study
ConclusionsRiociguat treatment was associated with increased RVSVI and trends for improvement in myocardial remodeling in CTEPH patients. A larger clinical study is warranted to observe the therapeutic benefits of riociguat on RV remodeling.
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research
Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients
ConclusionsHigh blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and ST were predictors of clinically apparent/silent brain infarction.
Source: Cor et Vasa - July 10, 2018 Category: Cardiology Source Type: research
MRI-derived Regional Biventricular Function in Patients with Chronic Thromboembolic Pulmonary Hypertension Before and After Pulmonary Endarterectomy
ConclusionWhile biventricular resynchronization and recovery of global predominantly RV function was observed, regional circumferential function mainly improved in the lateral and inferior walls of both ventricles and regional radial function in the RV wall and septum 12 days after PEA, suggesting fibers primarily affected by myocardial stress in patients with CTEPH possibly need a relatively longer recovery time.
Source: Academic Radiology - July 10, 2018 Category: Radiology Source Type: research
Evaluation of the effects of right ventricular pressure load on left ventricular myocardial mechanics in patients with chronic obstructive pulmonary disease by ultrasound speckle tracking imaging.
CONCLUSIONS: Left ventricular whole peak rotation angle can be used to sensitively evaluate the change of left ventricular myocardial mechanics function in PH patients, and can reflect changes of left ventricular myocardial mechanics function in patients with COPD when mild PH occurs.
PMID: 30070330 [PubMed - in process]
Source: Pharmacological Reviews - August 1, 2018 Category: Drugs & Pharmacology Authors: Xia YJ, Sun HY, Jiang L, Liu B, Wang YY Tags: Eur Rev Med Pharmacol Sci Source Type: research
Noninvasive determination of the pulmonary artery input impedance
A reliable noninvasive method for the estimation of pulmonary function in healthy and diseased subjects should be of great importance in the prognosis, diagnosis, and treatment of pulmonary hypertension. Here we propose such a method, which is based on the parameter identification of the five-element Windkessel model of pulmonary circulation. The method requires the following input variables: the heart rate, the stroke volume, the Doppler echocardiographic measurements of the tricuspid regurgitation and the pulmonary valve velocity profiles, and estimations of the right atrium and the pulmonary vein pressure.
Source: Medical Hypotheses - August 9, 2018 Category: Biomedical Science Authors: Fabijan Luli ć, Zdravko Virag, Marko Jakopović, Ivan Korade Source Type: research
Preoperative Venoarterial Extracorporeal Membrane Oxygenation Slashes Risk Score in Advanced Structural Heart Disease
ConclusionsECMO can be used as a bridge to heart valve or septal defect surgery in severely decompensated patients. Through recovery of end-organ function, ECMO may allow surgical correction of structural heart disease in patients considered inoperable or convert a salvage situation to an elective operation.
Source: The Annals of Thoracic Surgery - September 18, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Preoperative Venoarterial Extracorporeal Membrane Oxygenation Slashes Risk Score in Advanced Structural Heart Disease.
CONCLUSIONS: ECMO can be used as a bridge to heart valve or septal defect surgery in severely decompensated patients. Through recovery of end-organ function, ECMO may allow surgical correction of structural heart disease in patients considered inoperable or convert a salvage situation to an elective operation.
PMID: 30236527 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - September 17, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Watkins AC, Maassel NL, Ghoreishi M, Dawood MY, Pham SM, Kon ZN, Taylor BS, Griffith BP, Gammie JS Tags: Ann Thorac Surg Source Type: research
Cardiovascular Manifestations Seen in Obstructive Sleep Apnea
Patients with obstructive sleep apnea (OSA) have an increased prevalence of systemic and pulmonary hypertension, left ventricular (LV) hypertrophy, LV systolic and diastolic dysfunction, and congestive heart failure, increased platelet aggregability, and increased susceptibility to thrombotic and embolic cardiac and cerebrovascular events. Patients with OSA have an increased prevalence of coronary artery disease, myocardial infarction, nocturnal angina, and myocardial ischemia, arrhythmias, and sudden cardiac death. Patients with OSA also have an increased prevalence of stroke. Treatment of OSA with continuous positive air...
Source: Comprehensive Therapy - September 27, 2007 Category: Primary Care Source Type: research
Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension
The prognostic importance of follow-up haemodynamics and the validity of multidimensional risk assessment are not well established for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH).
We assessed incident SSc-PAH patients to determine the association between clinical and haemodynamic variables at baseline and first follow-up right heart catheterisation (RHC) with transplant-free survival. RHC variables included cardiac index, stroke volume index (SVI), pulmonary arterial compliance and pulmonary vascular resistance. Risk assessment was performed according to the number of low-risk criteria: functi...
Source: European Respiratory Journal - October 18, 2018 Category: Respiratory Medicine Authors: Weatherald, J., Boucly, A., Launay, D., Cottin, V., Prevot, G., Bourlier, D., Dauphin, C., Chaouat, A., Savale, L., Jaïs, X., Jevnikar, M., Traclet, J., De Groote, P., Simonneau, G., Hachulla, E., Mouthon, L., Montani, D., Humbert, M., Sitbon, O. Tags: Original Articles: Pulmonary hypertension Source Type: research
Acute Massive and Submassive Pulmonary Embolism: Preliminary Validation of Aspiration Mechanical Thrombectomy in Patients with Contraindications to Thrombolysis
ConclusionThe high technical and clinical success of the procedure employed in this study suggests that aspiration mechanical thrombectomy is a promising technique when used alone. More extensive prospective studies are needed to assess the feasibility of this treatment.
Source: CardioVascular and Interventional Radiology - November 15, 2018 Category: Radiology Source Type: research
Lower than expected pulsatile pulmonary arterial load in a thromboembolic pulmonary hypertension model
Conclusions: To our knowledge, this is the first documentation of a PH state where the mPAP-corrected indices of pulsatile arterial load (sPAP, PAPp) were lower than expected. The young age of the animals, the short-term nature of our analysis, or some specific features of the thromboembolic PH model may be involved.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boulate, D., Chemla, D., Loisel, F., Coblence, M., Provost, B., Decante, B., Herve, P., Fadel, E., Mercier, O. Tags: Pulmonary hypertension Source Type: research
