In reply: Stroke in pulmonary hypertension: Is it predictable or preventable?

We thank Wang et al. for their comments and for bringing forward the challenges in managing care of patients with pulmonary hypertension (PH) and stroke. We acknowledge multiple possible mechanisms of stroke in patients with PH, and we highlighted them in our work, including paradoxical emboli and atrial fibrillation [1]. However, polycythemia (increased red cells) or other myeloproliferative disorders are considered to be a cause and not a consequence of PH [2,3]. In mice models, Sala et al. have showed that chronic hypoxia could lead to both PH and polycythemia [4].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research

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Publication date: 2020Source: European Journal of Radiology Open, Volume 7Author(s): Hiroki Kamada, Hideki Ota, Yosuke Terui, Koichiro Sugimura, Shigefumi Fukui, Hiroaki Shimokawa, Kei TakaseAbstractPulmonary tumor thrombotic microangiopathy (PTTM) is a specific type of tumor embolism in the small and medium pulmonary arteries, leading to rapid progressive pulmonary hypertension. Antemortem diagnosis of PTTM is extremely difficult. We encountered three patients who were histopathologically or clinically diagnosed with PTTM. In all cases, lung perfused blood volume (PBV) images on dual-energy computed tomography (CT) demons...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
Eko, a maker of high-end digital stethoscopes, has just received the first FDA clearance for its devices to use AI algorithms to automatically detect atrial fibrillation (AFib) and heart murmurs. Using this capability, primary care physicians, who ar...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Pediatrics Source Type: blogs
ConclusionsThese findings suggest that MXYF inhibits autophagy after OGD/R-induced PC12 cell injury through the AMPK-mTOR pathway. Thus, MXYF might have therapeutic potential in treating ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study aims to observe the role of target miRNA(miR-652) of NOX2 in ischemic stroke. A rat cerebral ischemia/reperfusion (CI/R) injury model and an SH-SY5Y cell hypoxia/reoxygenation(H/R) model were used to simulate ischemic stroke, and corresponding gene expression, biochemical indicators and pathophysiological indicators were measured to observe the role of miR-652. NOX2 significantly increased in brain tissues subjected to I/R or in SH-SY5Y cells subjected to H/R, while the expression level of miR-652(potential target of NOX2) significantly decreased in both brain tissues and plasma. Overexpression of miR-652 signif...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The buildup of plaques within blood vessel walls is the underlying cause of strokes and heart attacks. These plaques contain many dead or dying cells that are not flushed out by the immune system fast enough. Now, researchers from Stanford are re...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Cardiology Materials Medicine Nanomedicine Vascular Surgery Source Type: blogs
This study aimed to investigate echocardiographic features in patients with newly diagnosed T2DM, exploring changes in cardiac structure and function. MATERIAL AND METHODS This was a retrospective study of new T2DM cases treated at the Second People's Hospital Affiliated to Nanjing Medical University (Changzhou) in 2014-2016. In all, 128 T2DM cases were included (62 hypertensive and 66 non-hypertensive individuals). Controls were selected among individuals who underwent examination at the same department/period. Interventricular septal thickness (IVST), left ventricular end-diastolic diameter (LVEDD), posterior left ventri...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
BY JESSICA DAMASSA BioLum Sciences is introducing new chemistry that has the potential to completely change the way we test for respiratory illnesses, like asthma, and analyze blood samples to identify hypertension. CEO Edward Allegra talks through the science behind both their breath and blood tests, both of which are patent-pending and have the ability to completely bend the cost-curve when it comes to identifying and monitoring these two common chronic conditions. What’s next for the early-stage health startup? A range of applications to detect everything from COPD to lung cancer and more. Filmed at Bayer G...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Tech Jessica DaMassa WTF Health Asthma Bayer G4A Bayer G4A Signing Day BioLum BioLum Sciences Edward Allegra Hypertension Source Type: blogs
ConclusionsIn this high-risk, low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Conditions:   Interaction;   Hypertension;   Adverse Event;   Heart Failure;   Cardiovascular Diseases;   Drug Drug Interaction Intervention:   Combination Product: Candesartan/Amlodipine/Atorvastatin Sponsor:   Midas Pharma GmbH Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Cirrhosis;   Hypertension;   Splenectomy;   Laparoscopy Intervention:   Procedure: laparoscopic splenectomy and azygoportal disconnection with intraoperative endoscopic variceal ligation Sponsor:   Yangzhou University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Atrial Fibrillation | Cardiology | Heart | Hypertension | Myeloproliferative Disorders | Pulmonary Hypertension | Stroke