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Condition: Pulmonary Hypertension

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Total 621 results found since Jan 2013.

The Association Between Notching of the Right Ventricular Outflow Tract Flow Velocity Doppler Envelope and Impaired Right Ventricular Function After Acute High-Altitude Exposure
ConclusionHA exposure-induced RVOT notch formation is associated with impaired RV function, including no increase in the tricuspid ICV or s’, reduction of RV deformation, deterioration in RV-pulmonary artery coupling, and RV intraventricular synchrony.
Source: Frontiers in Physiology - April 1, 2021 Category: Physiology Source Type: research

Plasma proteoglycan prolargin in diagnosis and differentiation of pulmonary arterial hypertension
ConclusionsPlasma prolargin levels differentiate PAH patients from controls and the other investigated dyspnoea groups including HF. Its potential in PAH differentiation may be enhanced by inclusion in a multi ‐marker panel. Larger studies are needed to evaluate its discriminative ability of PAH in relation to other dyspnoea aetiologies and its potential role in PAH risk stratification and pathobiology.
Source: ESC Heart Failure - March 29, 2021 Category: Cardiology Authors: Mattias Arvidsson, Abdulla Ahmed, Habib Bouzina, G öran Rådegran Tags: Original Research Article Source Type: research

Effect of Supervised Training Therapy on Pulmonary Arterial Compliance and Stroke Volume in Severe Pulmonary Arterial Hypertension and Inoperable or Persistent Chronic Thromboembolic Pulmonary Hypertension
Conclusions: Our findings suggest that supervised exercise training may improve right ventricular function and PAC at the same time. Further prospective studies are needed to evaluate these findings.Respiration
Source: Respiration - March 25, 2021 Category: Respiratory Medicine Source Type: research

Prolonged Circulatory Arrest is Not Associated with Stroke or Mortality after Pulmonary Thromboendarterectomy
Patients with chronic thromboembolic pulmonary hypertension (CTEPH) frequently present with extensive distal clot burden, which adds complexity to pulmonary thromboendarterectomy (PTE). Complete endarterectomy often necessitates prolonged periods of hypothermic circulatory arrest (HCA), the ramifications of which are poorly understood. Objectives were to describe the association of HCA time with post-operative neurologic complications, operative mortality and other major morbidity after PTE.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: J.L. Armstrong, A.M. Vekstein, A. Seas, C.M. Wojnarski, A.M. Ganapathi, J.C. Haney Tags: (433) Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Indication of the prognosis of pulmonary hypertension by using CMR function parameters
ConclusionCHD-PH had a higher RV function reserve but lowest LVEF comparing to other subgroups. TAPSE and LVSVI could contribute to the prediction of MACE in PH patients.Key Points• CMR imaging is a noninvasive and accurate tool to assess ventricular function.• CHD-PH had higher RV function reserve but lowest LVEF.• TAPSE and LVSVI could contribute to the prediction of MACE in PH patients.
Source: European Radiology - March 18, 2021 Category: Radiology Source Type: research

Right ventricular pressure-volume loop shape and systolic pressure change in pulmonary hypertension
In conclusion, pressure-volume loop shape and RV systolic pressure differential predominately depend on afterload and PAH severity and reflect RV-arterial coupling in PAH.PMID:33655769 | DOI:10.1152/ajplung.00583.2020
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 3, 2021 Category: Cytology Authors: Manuel Jonas Richter Steven Hsu Athiththan Yogeswaran Faeq Husain-Syed Istv án Vadász Hossein Ardeschir Ghofrani Robert Naeije Sebastian Harth Friedrich Grimminger Werner Seeger Henning Gall Ryan Tedford Khodr Tello Source Type: research