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Condition: Pulmonary Hypertension

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Total 621 results found since Jan 2013.

Metalloproteinases and Their Inhibitors Are Associated with Pulmonary Arterial Stiffness and Ventricular Function in Pediatric Pulmonary Hypertension
Am J Physiol Heart Circ Physiol. 2021 Jun 4. doi: 10.1152/ajpheart.00750.2020. Online ahead of print.ABSTRACTDisturbed balance between matrix metalloproteinases (MMPs) and their respective tissue inhibitors (TIMPs) is a well-recognized pathophysiologic component of pulmonary arterial hypertension (PAH). Both classes of proteases have been associated with clinical outcomes as well as with specific pathologic features of ventricular dysfunction and pulmonary arterial remodeling. The purpose of this study was to evaluate the circulating levels of MMPs and TIMPs in children with PAH undergoing the same day cardiac MRI and righ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 4, 2021 Category: Physiology Authors: Michal Schafer D Dunbar Ivy Kathleen Nguyen Katie L Boncella Benjamin S Frank Gareth J Morgan Kathleen Miller-Reed Uyen Truong Kelley L Colvin Michael E Yeager Source Type: research

Cardiovascular magnetic resonance predicts all-cause mortality in pulmonary hypertension associated with heart failure with preserved ejection fraction
This study aimed to determine the prognostic value of cardiovascular magnetic resonance (CMR) in patients with heart failure with preserved ejection fraction and associated pulmonary hypertension (pulmonary hypertension-HFpEF). Patients with pulmonary hypertension-HFpEF were recruited from the ASPIRE registry and underwent right heart catheterisation (RHC) and CMR. On RHC, the inclusion criteria was a mean pulmonary artery pressure (MPAP)  ≥ 25 mmHg and pulmonary arterial wedge pressure >  15 mmHg and, on CMR, a left atrial volume >  41 ml/m2 with left ventricular ejection fraction  >  50%. Cox r...
Source: The International Journal of Cardiovascular Imaging - May 12, 2021 Category: Radiology Source Type: research

Inhibition of mTOR by rapamycin does not improve hypoxic pulmonary hypertension-induced right heart failure in old mice
Exp Gerontol. 2021 May 7:111395. doi: 10.1016/j.exger.2021.111395. Online ahead of print.ABSTRACTInhibition of the mammalian target of rapamycin (mTOR) by rapamycin attenuates heart failure (HF) and age-associated changes in left ventricular (LV) function. Rapamycin has also been suggested as a therapy for pulmonary hypertension (PH) and concomitant right heart failure (PH-RHF) based on reports of elevated mTOR signaling in young models with PH. However, rapamycin has yet to be tested in the setting of aging, PH, and right heart disease despite the fact that RV function predicts survival in both age-related HF as well as s...
Source: Experimental Gerontology - May 10, 2021 Category: Geriatrics Authors: Benjamin D McNair Jacob A Schlatter Ross F Cook Musharraf Yusifova Danielle R Bruns Source Type: research

Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction
ConclusionsThe RV ‐PA coupling ratio Ees/Ea predicts overall survival in PH due to HFREF and is mainly affected by pulsatile load, RV remodelling, and left ventricular dysfunction. Prognostically favourable coupling (RV‐Ees/Ea ≥ 0.68) in PH was associated with preserved RV size/function and mid‐term surviva l, comparable with HFREF without PH.
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Alexander Schmei ßer, Thomas Rauwolf, Thomas Groscheck, Katharina Fischbach, Siegfried Kropf, Blerim Luani, Ivan Tanev, Michael Hansen, Saskia Meißler, Kerstin Schäfer, Paul Steendijk, Ruediger C. Braun‐Dullaeus Tags: Original Research Article Source Type: research

Sildenafil Administration Improves Right Ventricular Function on 4D Flow MRI in Young Adults Born Premature
CONCLUSIONS: Despite reduced right atrial workload, metoprolol significantly depressed overall cardiac systolic function. Sildenafil, however, increased CI and improved RV function, as quantified by the direct flow fraction. The preterm heart appears dependent on HR, but sensitive to RV afterload manipulations.PMID:33861148 | DOI:10.1152/ajpheart.00824.2020
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Philip A Corrado Gregory P Barton Christopher J Fran çois Oliver Wieben Kara N Goss Source Type: research

Thrombolytic therapy for pulmonary embolism
CONCLUSIONS: Low-certainty evidence suggests that thrombolytics may reduce death following acute pulmonary embolism compared with heparin (the effectiveness was mainly driven by one trial with massive PE). Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause more major and minor haemorrhagic events, including haemorrhagic stroke. More studies of high methodological quality are needed to assess safety and cost effectiveness of thrombolytic therapy for people with pulmonary embolism.PMID:33857326 | DOI:10.1002/14651858.CD004437.pub6
Source: Cochrane Database of Systematic Reviews - April 15, 2021 Category: General Medicine Authors: Zhiliang Zuo Jirong Yue Bi Rong Dong Taixiang Wu Guan J Liu Qiukui Hao Source Type: research