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Condition: Pulmonary Hypertension
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Total 621 results found since Jan 2013.
Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10-12 week old swine model of neonatal oxidative injury
In conclusion, duration of neonatal hypoxia appears an important determinant of alterations in cardiopulmonary function that persist further into life. These changes encompass both the pulmonary vasculature, and the response of the heart to hypoxia and exercise. Abstract figure legend Exposure of Neonatal Swine to hypoxia for up to four weeks resulted in an increase in pulmonary vascular resistance (PVR) and right ventricular hypertrophy that persisted after recovery in normoxia. Exercise experiments revealed an increased dependency on nitric oxide (NO) to maintain a PVR low, as well as a reduced stroke volume (SV) during ...
Source: The Journal of Physiology - July 21, 2022 Category: Physiology Authors: Jarno J Steenhorst Alexander Hirsch Annemarie Verzijl Piotr Wielopolski Daphne de Wijs-Meijler Dirk J Duncker Irwin K M Reiss Daphne Merkus Source Type: research
Association between obstructive sleep apnea and cardiovascular diseases
Acta Biochim Biophys Sin (Shanghai). 2022 Jul 25. doi: 10.3724/abbs.2022084. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA) is a common respiratory disorder characterized by partial obstruction of upper respiratory tract and repetitive cessation of breathing during sleep. The etiology behind OSA is associated with the occurrence of intermittent hypoxemia, recurrent arousals and intrathoracic pressure swings. These contributing factors may turn on various signaling mechanisms including elevated sympathetic tone, oxidative stress, inflammation, endothelial dysfunction, cardiovascular variability, abnormal coagul...
Source: Acta Biochimica et Biophysica Sinica - July 15, 2022 Category: Biochemistry Authors: Yiran E Li Jun Ren Source Type: research
How we do it: evaluation of dyspnea and exercise intolerance after acute pulmonary embolism
Chest. 2022 Jul 2:S0012-3692(22)01215-6. doi: 10.1016/j.chest.2022.06.036. Online ahead of print.ABSTRACTLong-term dyspnea and exercise intolerance are common clinical problems after acute PE. Unfortunately, no single test can distinguish among the range of potential pathological outcomes after PE. We illustrate a stepwise approach to post-PE evaluation that uses a hierarchical series of clinically validated diagnostic tests. The algorithm is represented by the acronym SEARCH, which stands for symptom screening, exercise testing, arterial perfusion, resting echocardiography, confirmatory chest imaging and (right) heart cat...
Source: Chest - July 6, 2022 Category: Respiratory Medicine Authors: Timothy A Morris Timothy M Fernandes Richard Channick Source Type: research
Clinical value of echocardiography in evaluating hemodynamics and right ventricular function in patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty
CONCLUSIONS: The findings show that a single BPA procedure significantly improves RV volume load and reduces the pulmonary blood pressure in CTEPH patients in the short-term. However, BPA does not improve RV systolic function 24 hours after the procedure. The results indicate that evaluation of RV structural and function with echocardiography is an effective approach for non-invasive monitoring of patient status after BPA.PMID:35693626 | PMC:PMC9186241 | DOI:10.21037/jtd-21-1536
Source: Journal of Thoracic Disease - June 13, 2022 Category: Respiratory Medicine Authors: Jiaxin Chen Shangwei Ding Chenkai Zhang Rifei Li Wenliang Guo Chen Hong Qing Tang Source Type: research
