Author Response to the Letter Entitled “A Good and Reliable Bronchodilator Dose-Response Relationship”
Respiration (Source: Respiration)
Source: Respiration - September 9, 2020 Category: Respiratory Medicine Source Type: research

Influential Factors for Assessing Endobronchial Ultrasound Elastography
Respiration (Source: Respiration)
Source: Respiration - September 7, 2020 Category: Respiratory Medicine Source Type: research

Chest Computed Tomography Findings in Asymptomatic Patients with COVID-19
Conclusions: In conclusion, considering our results that the lung is affected in asymptomatic patients, it will be necessary to extend the indications of COVID-19 testing for effective management of COVID-19 during the pandemic.Respiration (Source: Respiration)
Source: Respiration - September 7, 2020 Category: Respiratory Medicine Source Type: research

Exercise Hemodynamics in the Prognosis of Patients with Pulmonary Arterial Hypertension
Conclusions: Rest-to-exercise changes in heart rate and systolic pulmonary artery pressure measured at diagnosis are predictors of survival in patients with PAH. These measurements taken from an exercise test reflect right ventricular function.Respiration (Source: Respiration)
Source: Respiration - August 28, 2020 Category: Respiratory Medicine Source Type: research

Sleep Breathing Disorders in the COVID-19 Era: Italian Thoracic Society Organizational Models for a Correct Approach to Diagnosis and Treatment
The attenuation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, at least in Italy, allows a gradual resumption of diagnostic and therapeutic activities for sleep respiratory disorders. The knowledge on this new disorder is growing fast, but our experience is still limited and when a physician cannot rely on evidence-based medicine, the experience of his peers can support the decision-making and operational process of reopening sleep laboratories. The aim of this paper is to focus on the safety of patients and operators accessing hospitals and the practice of diagnosing and treating sleep-related r...
Source: Respiration - August 27, 2020 Category: Respiratory Medicine Source Type: research

Older Idiopathic Pulmonary Fibrosis Male Patients Are at a Higher Risk of Nintedanib Dose Reduction
Conclusions: Male gender and not body mass index in IPF patients aged ≥80 years treated with nintedanib seems to influence dose reduction.Respiration (Source: Respiration)
Source: Respiration - August 27, 2020 Category: Respiratory Medicine Source Type: research

Management of Patients with Interstitial Lung Disease in the Midst of the COVID-19 Pandemic
Respiration (Source: Respiration)
Source: Respiration - August 25, 2020 Category: Respiratory Medicine Source Type: research

Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China
Conclusions: Advanced age, decreased lymphocytes, and D-Dimer elevation are important characteristics of patients with severe COVID-19. Clinicians should focus on these characteristics to identify high-risk patients at an early stage.Respiration (Source: Respiration)
Source: Respiration - August 25, 2020 Category: Respiratory Medicine Source Type: research

Effects of Vibration Training in Interstitial Lung Diseases: A Randomized Controlled Trial
Conclusions: The present study demonstrates that WBVT is able to significantly increase 6MWD and decrease myostatin in patients with fibrotic ILDs. Therefore, WBVT seems to be a beneficial and feasible training modality in ILD patients.Clinical Trial Registry: German Clinical Trials Registry (DRKS00012930).Respiration (Source: Respiration)
Source: Respiration - August 19, 2020 Category: Respiratory Medicine Source Type: research

Immune Modulation in Chronic Respiratory Diseases: The Path to Precision Medicine
Respiration (Source: Respiration)
Source: Respiration - August 13, 2020 Category: Respiratory Medicine Source Type: research

The Role of Bronchoscopy in COVID-19
Respiration (Source: Respiration)
Source: Respiration - August 7, 2020 Category: Respiratory Medicine Source Type: research

Inpatient Care during the COVID-19 Pandemic: A Survey of Italian Physicians
Conclusions: In our survey some major topics, such as the role of non-invasive respiratory support and drug treatments, show disagreement between experts, likely reflecting the absence of high-quality evidence studies. Considering the significant respiratory sequelae reported following COVID-19, proper respiratory and physical therapy programs should be promptly made available.Respiration (Source: Respiration)
Source: Respiration - August 5, 2020 Category: Respiratory Medicine Source Type: research

Supervised Exercise Training in Patients with Chronic Thromboembolic Pulmonary Hypertension as Early Follow-Up Treatment after Pulmonary Endarterectomy: A Prospective Cohort Study
Conclusions: Supervised exercise training was feasible as early follow-up treatment after PEA. Further controlled studies are needed to discriminate the effects of PEA and early follow-up rehabilitation.Trial Registration: The study was registered at clinicaltrials.gov (NCT01393327) on July 13, 2011. The study start date was January 2010, and completion date was December 2013.Respiration (Source: Respiration)
Source: Respiration - July 29, 2020 Category: Respiratory Medicine Source Type: research

Aspiration of Pericardial Effusion Performed with EUS-B-FNA in Suspected Lung Cancer
We present 2 cases of EUS-B-guided aspiration of malignant pericardial effusion performed in the same setting as bronchoscopy and endobronchial ultrasound. No complications were observed. We conclude that EUS-B-FNA may be safe and efficacious in the evaluation of pericardial effusion during lung cancer workup. Thus, EUS-B-FNA may save time in the diagnostic workup, improve cancer staging, and prevent transthoracic pericardiocentesis.Respiration (Source: Respiration)
Source: Respiration - July 29, 2020 Category: Respiratory Medicine Source Type: research

Delayed Diagnosis in Pulmonary Embolism: Frequency, Patient Characteristics, and Outcome
Conclusions: Delayed diagnosis of PE carries a worse prognosis than early diagnosis. This discrepancy may arise from either delayed therapy, confounding variables (e.g., older age), or both. Possible reasons for delayed diagnoses are nonspecific presentations and symptoms overlapping with preexisting conditions.Respiration (Source: Respiration)
Source: Respiration - July 21, 2020 Category: Respiratory Medicine Source Type: research

Presenting the Board of < b > < i > Respiration < /i > < /b > : Alfredo Chetta
Respiration (Source: Respiration)
Source: Respiration - July 17, 2020 Category: Respiratory Medicine Source Type: research

Azathioprine for Connective Tissue Disease-Associated Interstitial Lung Disease
Conclusions: Azathioprine can stabilize or improve CTD-ILD. While early drug intolerance is frequent, most patients who have tolerated the drug well achieve long-term stabilization or improvement of lung function.Respiration (Source: Respiration)
Source: Respiration - July 14, 2020 Category: Respiratory Medicine Source Type: research

Determinants of Clinical COPD Questionnaire in Patients with COPD: A Cross-Sectional Observational Study
Conclusions: The classification of COPD produced by mMRC, CAT, and CCQ was not identical. Smoking status, underweight, ACO, post-bronchodilator FEV1% predicted #x3c;50%, exacerbation history, and mMRC were associated with lower health-related quality of life assessed by the total CCQ score, while different subdomains of CCQ had different determinant factors.Respiration (Source: Respiration)
Source: Respiration - July 13, 2020 Category: Respiratory Medicine Source Type: research

Lung Ultrasound in COVID-19: Not Novel, but Necessary
Respiration (Source: Respiration)
Source: Respiration - July 13, 2020 Category: Respiratory Medicine Source Type: research

Respiratory Rehabilitation in the COVID-19 Era
Respiration (Source: Respiration)
Source: Respiration - July 13, 2020 Category: Respiratory Medicine Source Type: research

Differences in Lung and Lobe Volumes between Supine and Standing Positions Scanned with Conventional and Newly Developed 320-Detector-Row Upright CT: Intra-Individual Comparison
Conclusions: While the volumes of the bilateral upper and lower lobes and bilateral lungs were significantly greater in the standing than in the supine position, with lower lobes showing larger changes, the right middle lobe volume did not change significantly between positions. The total lung volume on upright CT in the standing position was more similar to TLC on PFT than that in the supine position.Respiration (Source: Respiration)
Source: Respiration - July 8, 2020 Category: Respiratory Medicine Source Type: research

Risk Factors of In-Hospital Mortality in Patients Treated for Pneumonia at a Tertiary Care Centre in Switzerland
Conclusions: Our data are consistent with previous trials characterizing patients hospitalized for pneumonia. Additionally, we identified new and independent risk factors associated with in-hospital death among patients treated for bacterial pneumonia. Findings need to be further validated in larger multicentre cohorts.Respiration (Source: Respiration)
Source: Respiration - July 7, 2020 Category: Respiratory Medicine Source Type: research

Lung Ultrasound in COVID-19 Pneumonia: Correlations with Chest CT on Hospital admission
Conclusion: When integrated with clinical data, LUS could represent a valid diagnostic aid in patients with suspect COVID-19 pneumonia, which reflects CT findings.Respiration (Source: Respiration)
Source: Respiration - June 22, 2020 Category: Respiratory Medicine Source Type: research

Position Paper for the State-of-the-Art Application of Respiratory Support in Patients with COVID-19
Against the background of the pandemic caused by infection with the SARS-CoV-2 virus, the German Respiratory Society has appointed experts to develop therapy strategies for COVID-19 patients with acute respiratory failure (ARF). Here we present key position statements including observations about the pathophysiology of (ARF). In terms of the pathophysiology of pulmonary infection with SARS-CoV-2, COVID-19 can be divided into 3 phases. Pulmonary damage in advanced COVID-19 often differs from the known changes in acute respiratory distress syndrome (ARDS). Two types (type L and type H) are differentiated, corresponding to ea...
Source: Respiration - June 19, 2020 Category: Respiratory Medicine Source Type: research

Temporary Right Middle Lobe Occlusion with a Blocking Device to Enable Collateral Ventilation Measurement of the Right Major Fissure
Conclusion: Temporary middle lobe occlusion using a blocking device is helpful in obtaining a reliable Chartis outcome in case of a right lower lobe no-flow phenomenon.Respiration (Source: Respiration)
Source: Respiration - June 9, 2020 Category: Respiratory Medicine Source Type: research

Immune Modulation in Asthma: Current Concepts and Future Strategies
Asthma treatment concepts have profoundly changed over the last 20 years, from standard therapeutic regimens for all patients with asthma towards individually tailored interventions targeting treatable traits ( “precision medicine”). A precise and highly effective immune modulation with minimal adverse effects plays a central role in this new concept. Recently, there have been major advances in the treatment of asthma with immune-modulatory compounds. One example is the approval of several highly poten t biologics for the treatment of severe asthma. New immune-modulatory strategies are expected to enter clinica...
Source: Respiration - June 8, 2020 Category: Respiratory Medicine Source Type: research

SSC/SSCS SSP/SSTS Joint Annual Meeting 2020
Respiration (Source: Respiration)
Source: Respiration - June 5, 2020 Category: Respiratory Medicine Source Type: research

Endoscopic Lung Volume Reduction in Relation to Body Mass Index in Patients with Severe Heterogeneous Emphysema
Conclusion: Baseline BMI is relevant when selecting candidates for ELVR. Our results show that the COPD patients with a lower BMI gained a significant amount of weight, thus increasing their BMI after the procedure. The rate of complications was higher in the lower BMI group. These findings should alert physicians and encourage nutritional assessment in this population.Respiration (Source: Respiration)
Source: Respiration - June 3, 2020 Category: Respiratory Medicine Source Type: research

Predictive Value of Endobronchial Ultrasound Strain Elastography in Mediastinal Lymph Node Staging: The E-Predict Multicenter Study Results
Conclusions: EBUS-SE can help predict lymph node malignancy and may be useful for risk stratification when combined with size and PET information.Respiration (Source: Respiration)
Source: Respiration - June 3, 2020 Category: Respiratory Medicine Source Type: research

An International Survey of Mediastinal Staging Practices amongst Interventional Bronchoscopists
Conclusion: There are several areas of divergence between published guidelines and current practices reported by interventional bronchoscopists. EBUS alone is the most widely used endoscopic procedure for mediastinal staging in lung cancer, and a combined endoscopic approach is frequently omitted by the responders. A fellowship program appears to be associated with a higher rate of systematic endoscopic staging procedures.Respiration (Source: Respiration)
Source: Respiration - June 2, 2020 Category: Respiratory Medicine Source Type: research

Clinical Predictors of Successful and Earlier Removal of Indwelling Pleural Catheters in Benign Pleural Effusions
Conclusions: IPCs are safe in benign effusions. Clinicians should consider numerous factors when predicting the rate of and time to pleurodesis.Respiration (Source: Respiration)
Source: Respiration - July 2, 2019 Category: Respiratory Medicine Source Type: research

The Relevance of Family History Taking in the Detection and Management of Birt-Hogg-Dub é Syndrome
Conclusions: Although BHDS is considered a rare disease, BHDS underlies spontaneous pneumothorax more often than usually believed, especially whenever a family history of pneumothorax is present. Diagnosis of BHDS is essential to start monitoring patients for the risk of developing renal malignancies.Respiration (Source: Respiration)
Source: Respiration - July 2, 2019 Category: Respiratory Medicine Source Type: research

Quantitative Evaluation of Lobar Pulmonary Function of Emphysema Patients with Endobronchial Coils
Conclusions: CT-derived lobar volume and emphysema quantification using the LungSeg program is efficient and reliable in allowing lobar volume assessment. LungSeg has low inter-user variability and agrees better with plethysmography for COPD assessment in our study.Respiration (Source: Respiration)
Source: Respiration - June 25, 2019 Category: Respiratory Medicine Source Type: research

Contents
Respiration 2019;97:I –VI (Source: Respiration)
Source: Respiration - June 21, 2019 Category: Respiratory Medicine Source Type: research

Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients
Conclusions: The results demonstrate acceptable safety and feasibility of TLD in patients with COPD, with improvements in adverse event rates after procedural enhancements.Respiration (Source: Respiration)
Source: Respiration - June 20, 2019 Category: Respiratory Medicine Source Type: research

A Calibration Technique for the Estimation of Lung Volumes in Nonintubated Subjects by Electrical Impedance Tomography
Conclusion: A simple and fast EIT calibration technique enables reliable, noninvasive monitoring of Vt in nonintubated subjects.Respiration (Source: Respiration)
Source: Respiration - June 13, 2019 Category: Respiratory Medicine Source Type: research

Frontiers in Clinical Practice of Long-Term Care of Chronic Ventilatory Failure
Home mechanical ventilation (HMV) is an effective long-term treatment for chronic hypercapnic respiratory failure. In addition to the established practice of providing HMV for the treatment of chronic ventilatory failure in slowly progressive neuromuscular and chest wall disease, there is accumulating evidence for improvement of quality of life and prolongation of survival by HMV in highly prevalent diseases like chronic obstructive pulmonary disease and ever-increasing obesity hypoventilation syndrome as well as rapidly progressive neuromuscular disease. The key concepts for successful HMV are an experienced team selectin...
Source: Respiration - June 6, 2019 Category: Respiratory Medicine Source Type: research

Lobar Quantification by Ventilation/Perfusion SPECT/CT in Patients with Severe Emphysema Undergoing Lung Volume Reduction with Endobronchial Valves
Conclusion: Semi-automatic SPECT/CT analysis can quantify volume, ventilation and perfusion changes in pulmonary lobes and may be used in the assessment of patient eligibility for ELVR, identifying target lobes, and evaluation of the regional effects of treatment.Respiration (Source: Respiration)
Source: Respiration - June 5, 2019 Category: Respiratory Medicine Source Type: research

Development of and Gathering Validity Evidence for a Theoretical Test in Thoracic Ultrasound
Conclusion: The established MCQ test can distinguish between physicians with different levels of competence in TUS and enables an objective, evidence-based approach for assessing the theoretical knowledge of trainees undergoing an educational programme in TUS.Respiration (Source: Respiration)
Source: Respiration - May 28, 2019 Category: Respiratory Medicine Source Type: research

Automatic versus Manual Oxygen Titration in Patients Requiring Supplemental Oxygen in the Hospital: A Systematic Review and Meta-Analysis
Conclusions: In patients requiring supplemental oxygen in the hospital, automatic oxygen titration was associated with a reduction in length of both hospital stay and oxygen therapy, as well as a greater percentage of time spent within the saturation target range. However, it was not associated with a significant difference in the need for mechanical ventilation or in mortality. Results should be interpreted with caution due to the small number of included trials and their high risk of bias.Respiration (Source: Respiration)
Source: Respiration - May 24, 2019 Category: Respiratory Medicine Source Type: research

Malignant Pleural Effusion at Presentation in Patients with Small-Cell Lung Cancer
Conclusions: MPE is common at presentation (11%) in patients with SCLC and may be associated with decreased survival. Additional studies are required to assess the treatment-adjusted survival rate in the setting of MPE.Respiration (Source: Respiration)
Source: Respiration - May 23, 2019 Category: Respiratory Medicine Source Type: research

Transbronchial Biopsy Using an Ultrathin Bronchoscope Guided by Cone-Beam Computed Tomography and Virtual Bronchoscopic Navigation in the Diagnosis of Pulmonary Nodules
Conclusions: Transbronchial biopsy using an ultrathin bronchoscope guided by CBCT and VBN showed a very high yield in the diagnosis of pulmonary nodules.Respiration (Source: Respiration)
Source: Respiration - May 23, 2019 Category: Respiratory Medicine Source Type: research

Successful Lung Volume Reduction Surgery after Endobronchial Coils Treatment in a Severe Emphysematous Patient
We describe the first successful LVRS in an emphysematous patient who displayed no benefit, either clinically or functionally, from a previous ECT. LVRS was performed in the right lower lobe 4 years after ECT in the same lobe. An air leak persisted for 18 days after LVRS, with no requirement for surgery or endobronchial treatment. Six months after LVRS, the patient dramatically improved with a decrease in hyperinflation and dyspnea.Respiration (Source: Respiration)
Source: Respiration - May 22, 2019 Category: Respiratory Medicine Source Type: research

Bronchoscopic Lung Volume Reduction with Endobronchial Zephyr Valves for Severe Emphysema: A Systematic Review and Meta-Analysis
Conclusion: In this population, Zephyr valves provided significant and clinically meaningful short-term improvements in either homogeneous or heterogeneous emphysema without CV but with an increase in adverse events.Respiration (Source: Respiration)
Source: Respiration - May 22, 2019 Category: Respiratory Medicine Source Type: research

Indwelling Pleural Catheters for Malignant Pleural Effusions: Is the LunGO System the Poor Man ’s Indwelling Pleural Catheter?
Respiration (Source: Respiration)
Source: Respiration - May 20, 2019 Category: Respiratory Medicine Source Type: research

Inhaled Treatments and the Future of Respiratory Diseases: Holding Our Breath
Respiration (Source: Respiration)
Source: Respiration - May 17, 2019 Category: Respiratory Medicine Source Type: research

A Retrospective Study on Efficacy and Safety of Rivaroxaban and Dalteparin for Long-Term Treatment of Venous Thromboembolism in Patients with Lung Cancer
Conclusions: There was no difference in the safety and efficacy profile of rivaroxaban compared with dalteparin. Therefore, rivaroxaban may be a valuable treatment option for lung cancer-associated VTE.Respiration (Source: Respiration)
Source: Respiration - May 16, 2019 Category: Respiratory Medicine Source Type: research

ARDS after Cardiac Surgery: Is It a Problem, a Problem of Definition, or Both?
Respiration (Source: Respiration)
Source: Respiration - May 8, 2019 Category: Respiratory Medicine Source Type: research

Role of Quantitative Computed Tomographic Scan Analysis in Lung Volume Reduction for Emphysema
Recent advances in bronchoscopic lung volume reduction (BLVR) offer new therapeutic alternatives for patients with emphysema and hyperinflation. Endobronchial valves and coils are 2 potential BLVR techniques which have been shown to improve pulmonary function and the quality of life in patients with emphysema. Current patient selection for LVR procedures relies on 3 main inclusion criteria: low attenuation area (in %), also known as emphysema score, heterogeneity score, and fissure integrity score. Volumetric analysis in combination with densitometric analysis of the affected lung lobe or segment with quantitative CT to de...
Source: Respiration - May 8, 2019 Category: Respiratory Medicine Source Type: research

Analysis of the Clinical Features of Tracheobronchial Fungal Infections with Tumor-Like Lesions
Conclusion: Immunocompromised patients and immunocompetent patients with underlying disease displaying tumor-like lesions on bronchoscopy should be differentially diagnosed with cancer. Bronchial biopsy is indispensable for the early diagnosis of TBFI.Respiration (Source: Respiration)
Source: Respiration - May 8, 2019 Category: Respiratory Medicine Source Type: research