Clinical Predictors of Successful and Earlier Removal of Indwelling Pleural Catheters in Benign Pleural Effusions
Conclusions: IPCs are safe in benign effusions. Clinicians should consider numerous factors when predicting the rate of and time to pleurodesis.Respiration (Source: Respiration)
Source: Respiration - July 2, 2019 Category: Respiratory Medicine Source Type: research

The Relevance of Family History Taking in the Detection and Management of Birt-Hogg-Dub é Syndrome
Conclusions: Although BHDS is considered a rare disease, BHDS underlies spontaneous pneumothorax more often than usually believed, especially whenever a family history of pneumothorax is present. Diagnosis of BHDS is essential to start monitoring patients for the risk of developing renal malignancies.Respiration (Source: Respiration)
Source: Respiration - July 2, 2019 Category: Respiratory Medicine Source Type: research

Quantitative Evaluation of Lobar Pulmonary Function of Emphysema Patients with Endobronchial Coils
Conclusions: CT-derived lobar volume and emphysema quantification using the LungSeg program is efficient and reliable in allowing lobar volume assessment. LungSeg has low inter-user variability and agrees better with plethysmography for COPD assessment in our study.Respiration (Source: Respiration)
Source: Respiration - June 25, 2019 Category: Respiratory Medicine Source Type: research

Contents
Respiration 2019;97:I –VI (Source: Respiration)
Source: Respiration - June 21, 2019 Category: Respiratory Medicine Source Type: research

Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients
Conclusions: The results demonstrate acceptable safety and feasibility of TLD in patients with COPD, with improvements in adverse event rates after procedural enhancements.Respiration (Source: Respiration)
Source: Respiration - June 20, 2019 Category: Respiratory Medicine Source Type: research

A Calibration Technique for the Estimation of Lung Volumes in Nonintubated Subjects by Electrical Impedance Tomography
Conclusion: A simple and fast EIT calibration technique enables reliable, noninvasive monitoring of Vt in nonintubated subjects.Respiration (Source: Respiration)
Source: Respiration - June 13, 2019 Category: Respiratory Medicine Source Type: research

Frontiers in Clinical Practice of Long-Term Care of Chronic Ventilatory Failure
Home mechanical ventilation (HMV) is an effective long-term treatment for chronic hypercapnic respiratory failure. In addition to the established practice of providing HMV for the treatment of chronic ventilatory failure in slowly progressive neuromuscular and chest wall disease, there is accumulating evidence for improvement of quality of life and prolongation of survival by HMV in highly prevalent diseases like chronic obstructive pulmonary disease and ever-increasing obesity hypoventilation syndrome as well as rapidly progressive neuromuscular disease. The key concepts for successful HMV are an experienced team selectin...
Source: Respiration - June 6, 2019 Category: Respiratory Medicine Source Type: research

Lobar Quantification by Ventilation/Perfusion SPECT/CT in Patients with Severe Emphysema Undergoing Lung Volume Reduction with Endobronchial Valves
Conclusion: Semi-automatic SPECT/CT analysis can quantify volume, ventilation and perfusion changes in pulmonary lobes and may be used in the assessment of patient eligibility for ELVR, identifying target lobes, and evaluation of the regional effects of treatment.Respiration (Source: Respiration)
Source: Respiration - June 5, 2019 Category: Respiratory Medicine Source Type: research

Development of and Gathering Validity Evidence for a Theoretical Test in Thoracic Ultrasound
Conclusion: The established MCQ test can distinguish between physicians with different levels of competence in TUS and enables an objective, evidence-based approach for assessing the theoretical knowledge of trainees undergoing an educational programme in TUS.Respiration (Source: Respiration)
Source: Respiration - May 28, 2019 Category: Respiratory Medicine Source Type: research

Automatic versus Manual Oxygen Titration in Patients Requiring Supplemental Oxygen in the Hospital: A Systematic Review and Meta-Analysis
Conclusions: In patients requiring supplemental oxygen in the hospital, automatic oxygen titration was associated with a reduction in length of both hospital stay and oxygen therapy, as well as a greater percentage of time spent within the saturation target range. However, it was not associated with a significant difference in the need for mechanical ventilation or in mortality. Results should be interpreted with caution due to the small number of included trials and their high risk of bias.Respiration (Source: Respiration)
Source: Respiration - May 24, 2019 Category: Respiratory Medicine Source Type: research

Malignant Pleural Effusion at Presentation in Patients with Small-Cell Lung Cancer
Conclusions: MPE is common at presentation (11%) in patients with SCLC and may be associated with decreased survival. Additional studies are required to assess the treatment-adjusted survival rate in the setting of MPE.Respiration (Source: Respiration)
Source: Respiration - May 23, 2019 Category: Respiratory Medicine Source Type: research

Transbronchial Biopsy Using an Ultrathin Bronchoscope Guided by Cone-Beam Computed Tomography and Virtual Bronchoscopic Navigation in the Diagnosis of Pulmonary Nodules
Conclusions: Transbronchial biopsy using an ultrathin bronchoscope guided by CBCT and VBN showed a very high yield in the diagnosis of pulmonary nodules.Respiration (Source: Respiration)
Source: Respiration - May 23, 2019 Category: Respiratory Medicine Source Type: research

Successful Lung Volume Reduction Surgery after Endobronchial Coils Treatment in a Severe Emphysematous Patient
We describe the first successful LVRS in an emphysematous patient who displayed no benefit, either clinically or functionally, from a previous ECT. LVRS was performed in the right lower lobe 4 years after ECT in the same lobe. An air leak persisted for 18 days after LVRS, with no requirement for surgery or endobronchial treatment. Six months after LVRS, the patient dramatically improved with a decrease in hyperinflation and dyspnea.Respiration (Source: Respiration)
Source: Respiration - May 22, 2019 Category: Respiratory Medicine Source Type: research

Bronchoscopic Lung Volume Reduction with Endobronchial Zephyr Valves for Severe Emphysema: A Systematic Review and Meta-Analysis
Conclusion: In this population, Zephyr valves provided significant and clinically meaningful short-term improvements in either homogeneous or heterogeneous emphysema without CV but with an increase in adverse events.Respiration (Source: Respiration)
Source: Respiration - May 22, 2019 Category: Respiratory Medicine Source Type: research

Indwelling Pleural Catheters for Malignant Pleural Effusions: Is the LunGO System the Poor Man ’s Indwelling Pleural Catheter?
Respiration (Source: Respiration)
Source: Respiration - May 20, 2019 Category: Respiratory Medicine Source Type: research

Inhaled Treatments and the Future of Respiratory Diseases: Holding Our Breath
Respiration (Source: Respiration)
Source: Respiration - May 17, 2019 Category: Respiratory Medicine Source Type: research

A Retrospective Study on Efficacy and Safety of Rivaroxaban and Dalteparin for Long-Term Treatment of Venous Thromboembolism in Patients with Lung Cancer
Conclusions: There was no difference in the safety and efficacy profile of rivaroxaban compared with dalteparin. Therefore, rivaroxaban may be a valuable treatment option for lung cancer-associated VTE.Respiration (Source: Respiration)
Source: Respiration - May 16, 2019 Category: Respiratory Medicine Source Type: research

ARDS after Cardiac Surgery: Is It a Problem, a Problem of Definition, or Both?
Respiration (Source: Respiration)
Source: Respiration - May 8, 2019 Category: Respiratory Medicine Source Type: research

Role of Quantitative Computed Tomographic Scan Analysis in Lung Volume Reduction for Emphysema
Recent advances in bronchoscopic lung volume reduction (BLVR) offer new therapeutic alternatives for patients with emphysema and hyperinflation. Endobronchial valves and coils are 2 potential BLVR techniques which have been shown to improve pulmonary function and the quality of life in patients with emphysema. Current patient selection for LVR procedures relies on 3 main inclusion criteria: low attenuation area (in %), also known as emphysema score, heterogeneity score, and fissure integrity score. Volumetric analysis in combination with densitometric analysis of the affected lung lobe or segment with quantitative CT to de...
Source: Respiration - May 8, 2019 Category: Respiratory Medicine Source Type: research

Analysis of the Clinical Features of Tracheobronchial Fungal Infections with Tumor-Like Lesions
Conclusion: Immunocompromised patients and immunocompetent patients with underlying disease displaying tumor-like lesions on bronchoscopy should be differentially diagnosed with cancer. Bronchial biopsy is indispensable for the early diagnosis of TBFI.Respiration (Source: Respiration)
Source: Respiration - May 8, 2019 Category: Respiratory Medicine Source Type: research

Simple Anatomical Calculations Possibly As Accurate As Three-Dimensional Lobar Quantification with SPECT-CT in Predicting Lung Function after Pulmonary Resection
The estimation of predicted postoperative (PPO) lung function is important in lung resection candidates. We utilized simple anatomical calculations and single-photon emission computed tomography combined with computed tomography (SPECT-CT) to calculate PPO in 24 consecutive patients with impaired pulmonary function who underwent lung resection. PPO values calculated by anatomical calculations and three-dimensional lobar SPECT-CT quantification both correlated well with the postoperative forced expiratory volume in 1 s, withr = 0.825,p #x3c; 0.001 andr = 0.796,p #x3c; 0.001, respectively. Both techniques fared well at predi...
Source: Respiration - May 5, 2019 Category: Respiratory Medicine Source Type: research

The Impact of Bronchial Thermoplasty on Asthma-Related Quality of Life and Controller Medication Use
Conclusion: In patients with severe persistent asthma and low asthma-related QOL scores, BT leads to an improvement in asthma-related QOL and a decrease in asthma medication use when measured 1 year after the final BT treatment.Respiration (Source: Respiration)
Source: Respiration - May 5, 2019 Category: Respiratory Medicine Source Type: research

SGP Congress 2019
Respiration (Source: Respiration)
Source: Respiration - April 25, 2019 Category: Respiratory Medicine Source Type: research

The Low-Cost, Long-Term Indwelling Pleural Catheter (LunGO): An Inexpensive and Effective Alternative for the Management of Dyspnea Associated with Malignant Pleural Effusions
Conclusion: LunGO was shown to be a viable and safe device for the treatment of symptomatic MPE.Respiration (Source: Respiration)
Source: Respiration - April 25, 2019 Category: Respiratory Medicine Source Type: research

Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?
Conclusions: MIP and SNIP were equally feasible. There was no significant bias in favor of either test, but a considerable disparity in results between tests, suggesting that use of both tests is warranted to screen for early detection of patients at risk of respiratory failure and avoid over diagnoses. SNIP, MIP, and VC all follow a relatively linear downhill course with a steeper slope for “bulbar” versus “non-bulbar” patients.Respiration (Source: Respiration)
Source: Respiration - April 25, 2019 Category: Respiratory Medicine Source Type: research

Pleural Cryobiopsy versus Flexible Forceps Biopsy in Subjects with Undiagnosed Exudative Pleural Effusions Undergoing Semirigid Thoracoscopy: A Crossover Randomized Trial (COFFEE Trial)
Conclusion: The diagnostic yield of pleural CB was comparable to FFB during semirigid thoracoscopy.Respiration (Source: Respiration)
Source: Respiration - April 25, 2019 Category: Respiratory Medicine Source Type: research

Delays in the Diagnosis and Treatment of Tuberculous Lymphadenitis in Low-Incidence Countries: A Systematic Review
Early detection and treatment of tuberculosis (TB) is essential to achieve the goals appointed in the WHO End TB Strategy. Tuberculous lymphadenitis (TBLA) is the most common manifestation of extrapulmonary TB, but the diagnosis can be challenging in low-incidence countries due to sparse and inconsistent clinical features, resulting in delay. We aimed to summarize and discuss the current literature on patient delay, health care delay, and total delay (i.e., time to first health care contact, diagnosis, and treatment) in patients with TBLA in TB low-incidence countries. A systematic review using PubMed was conducted, search...
Source: Respiration - April 17, 2019 Category: Respiratory Medicine Source Type: research

The Impact of Continuous Positive Airway Pressure upon Pleural Fluid Pressures during Thoracentesis
Conclusion: The application of CPAP at +5 cm H2O mitigates the decreases in Ppl caused by thoracentesis via an increase in pleural compliance. The clinical implications of this finding merit study.Respiration (Source: Respiration)
Source: Respiration - April 17, 2019 Category: Respiratory Medicine Source Type: research

Safety and Efficacy of Early and Long-Term Use of Pirfenidone in Idiopathic Pulmonary Fibrosis
Respiration (Source: Respiration)
Source: Respiration - April 15, 2019 Category: Respiratory Medicine Source Type: research

A New-Designed Lung-Bending Device for Bronchoscopic Lung Volume Reduction of Severe Emphysema: A Feasibility Study in Pigs
Conclusions: This study showed that Reversers were safe and feasible for bronchoscopic lung volume reduction in pigs.Respiration (Source: Respiration)
Source: Respiration - April 15, 2019 Category: Respiratory Medicine Source Type: research

A 2-Year Observational Study in Patients Suffering from Idiopathic Pulmonary Fibrosis and Treated with Pirfenidone: A French Ancillary Study of PASSPORT
Conclusions: The efficacy data of FAS are consistent with the efficacy results of published phase III clinical trials in IPF. Approximately one third of IPF patients treated with pirfenidone in real-life settings were still under treatment 2 years after initiation. Safety data are consistent with the known safety profile of pirfenidone.Respiration (Source: Respiration)
Source: Respiration - April 15, 2019 Category: Respiratory Medicine Source Type: research

Interventional Bronchoscopy for the Treatment of Malignant Central Airway Stenosis: An Expert Recommendation for China
Malignant central airway stenosis refers to airway stenosis caused by primary or metastatic malignant tumors which may lead to different levels of dyspnea or asphyxia in patients. With the rapid development of interventional pulmonology, therapeutic bronchoscopy has become one of the main methods for the diagnosis and treatment of malignant central airway stenosis. However, the level of diagnosis and treatment of respiratory intervention techniques in China is uneven at present, the treatment methods are not uniform, the treatment effects vary greatly, and some treatments even lead to serious complications. The interventio...
Source: Respiration - April 15, 2019 Category: Respiratory Medicine Source Type: research

A Trained Pulmonologist Can Reliably Assess Endosonography-Derived Lymph Node Samples during Rapid On-Site Evaluation
Conclusions: A trained pulmonologist can reliably assess adequacy and malignancy for endosonography-derived samples, which could be useful in institutions where a cytopathologist/cytotechnician is not available regularly.Respiration (Source: Respiration)
Source: Respiration - April 15, 2019 Category: Respiratory Medicine Source Type: research

Similar Airway Function after Volitional Hyperpnea in Mild-Moderate Asthmatics and Healthy Controls
Conclusions: A bout of HYP does not lead to relevant bronchoconstriction and the observed changes in lung function and airway resistance are neither of the magnitude of clinical relevance, nor do they differ from responses in healthy individuals. Thus, HYP training can safely be tested as an airway-specific exercise training alternative (or add-on) modality to regular aerobic exercise training.Respiration (Source: Respiration)
Source: Respiration - April 3, 2019 Category: Respiratory Medicine Source Type: research

Muddied Waters: Echogenic Pleural Transudates Do Exist!
Respiration (Source: Respiration)
Source: Respiration - April 3, 2019 Category: Respiratory Medicine Source Type: research

Clinical and Economic Benefits of Upper Airway Stimulation for Obstructive Sleep Apnea in a European Setting
Conclusions: In the present model-based analysis, UAS therapy provides meaningful benefit to patient-relevant endpoints and is a cost-effective therapy in the German setting.Respiration (Source: Respiration)
Source: Respiration - March 31, 2019 Category: Respiratory Medicine Source Type: research

Disseminated Mycosis by < b > < i > Arthrocladium < /i > < /b > < b > < i > fulminans < /i > < /b > Jeopardizing a Patient with GATA2 Deficiency
GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungusArthrocladium fulminans following an infection withMycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.Respiration (Source: Respiration)
Source: Respiration - March 31, 2019 Category: Respiratory Medicine Source Type: research

Utility of Anti-DSF70 Antibodies to Predict Connective Tissue Disease in Patients Originally Presenting with Idiopathic Interstitial Pneumonia
Conclusions: The frequency of serum anti-DFS70 antibody is markedly decreased in patients with ILDs. Anti-DFS70 antibodies may be useful to predict CTD development in ILD patients.Respiration (Source: Respiration)
Source: Respiration - March 31, 2019 Category: Respiratory Medicine Source Type: research

Management of Persistent Air Leaks Using Endobronchial Autologous Blood Patch and Spigot Occlusion: A Multicentre Randomized Controlled Trial in China
Conclusion: ABP and BOS resulted in clinically meaningful outcomes, including higher success rate, duration of air leak stop, lung expansion, and hospital stay, with an acceptable safety profile.Respiration (Source: Respiration)
Source: Respiration - March 22, 2019 Category: Respiratory Medicine Source Type: research

Prospective Analysis of the Predictive Value of Sonographic Pleural Fluid Echogenicity for the Diagnosis of Exudative Effusion
Conclusions: Echogenicity of a pleural effusion has a low specificity for identifying an underlying exudate, and the echogenic qualities of the fluid should not influence clinical decision-making.Respiration (Source: Respiration)
Source: Respiration - March 20, 2019 Category: Respiratory Medicine Source Type: research

COPD: Rethinking Patient Management – How to Approach a Challenging Patient Group Successfully
In comparison to other chronically ill people, patients suffering from chronic obstructive pulmonary disease (COPD) have many additional difficulties to face and conquer. Due to the contribution of avoidable causes of their illness ( “smokers’ lung”), society holds people with COPD responsible for their disease, which in return often leads to stigmatization and social isolation. In addition, COPD patients commonly belong to a less privileged social class, own a low socioeconomic status, and lower education. Their physical symptoms are easily observable and – by employing moderate adherence – t...
Source: Respiration - March 15, 2019 Category: Respiratory Medicine Source Type: research

Is the Metronome-Paced Tachypnea Test (MPT) Ready for Clinical Use? Accuracy of the MPT in a Prospective and Clinical Study
Conclusion: MPT seems to be a good replacement for CPET in group studies. The mean amount of DH was not different between CPET and MPT. On an individual level, MPT cannot be used to identify hyperinflators; it should be kept in mind that MPT overdiagnoses DH. The amount of DH should not be interchanged between CPET and MPT.Respiration (Source: Respiration)
Source: Respiration - March 14, 2019 Category: Respiratory Medicine Source Type: research

Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusions
Conclusions: Our proposed criteria using simultaneously pleural fluid lactate dehydrogenase and pleural fluid cholesterol can identify an exudate with a sensitivity and an overall diagnostic accuracy similar to Light ’s criteria. It avoids simultaneous blood sampling, thus reducing patient discomfort and potential costs.Respiration (Source: Respiration)
Source: Respiration - March 7, 2019 Category: Respiratory Medicine Source Type: research

Endoscopic Lung Volume Reduction: An Expert Panel Recommendation – Update 2019
Endoscopic lung volume reduction (ELVR) therapies are gaining prominence as a treatment option with guideline recommendations by COPD GOLD and NICE and the recent FDA approval for endobronchial valves. The transition from an experiment-based therapy only to clinical care comes with new challenges. A significant volume of evidence-based data has been published; all data demonstrate consistent improvements in several aspects of patient outcomes. Patients suffering from severe air trapping and thoracic hyperinflation seem to benefit the most from ELVR. In addition to lung function, baseline assessment should ideally include c...
Source: Respiration - March 7, 2019 Category: Respiratory Medicine Source Type: research

The Cryoablation for Peripheral Pulmonary Lesions Using a Novel Flexible Bronchoscopic Cryoprobe in the ex vivo Pig Lung and Liver
Conclusion: A flexible cryoprobe using a bronchoscope in ex vivo pig lung and liver was a sufficiently safe treatment method.Respiration (Source: Respiration)
Source: Respiration - February 21, 2019 Category: Respiratory Medicine Source Type: research

A Design-Based Stereologic Method to Quantify the Tissue Changes Associated with a Novel Drug-Eluting Tracheobronchial Stent
Conclusion: Stenting doubles the volume of soft tissue in the trachea. Design-based stereology can quantify the tissue changes associated with airway stenting.Respiration (Source: Respiration)
Source: Respiration - February 20, 2019 Category: Respiratory Medicine Source Type: research

Effects of Breath-Hold Deep Diving on the Pulmonary System
This short review focuses on pulmonary injury in breath-hold (BH) divers. When practicing their extreme leisure sport, they are exposed to increased pressure on pulmonary gas volumes, hypoxia, and increased partial gas pressures. Increasing ambient pressures do present a serious problem to BH deep divers, because the semi-rigid thorax prevents the deformation required by the Boyle-Mariotte law. As a result, a negative-pressure barotrauma (lung squeeze) with acute hemoptysis is not uncommon. Respiratory maneuvers such as glossopharyngeal insufflation (GI) and glossopharyngeal exsufflation (GE) are practiced to prevent lung ...
Source: Respiration - February 15, 2019 Category: Respiratory Medicine Source Type: research

Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks
Conclusion: We recommend smears in laboratory workflows as the primary source of DNA for NGS following an EBUS procedure.Respiration (Source: Respiration)
Source: Respiration - February 7, 2019 Category: Respiratory Medicine Source Type: research

Long-Term Ventilation in Neuromuscular Patients: Review of Concerns, Beliefs, and Ethical Dilemmas
Background: Noninvasive mechanical ventilation (NIV) is an effective treatment in patients with neuromuscular diseases (NMD) to improve symptoms, quality of life, and survival.Summary: NIV should be used early in the course of respiratory muscle involvement in NMD patients and its requirements may increase over time. Therefore, training on technical equipment at home and advice on problem solving are warranted. Remote monitoring of ventilator parameters using built-in ventilator software is recommended. Telemedicine may be helpful in reducing hospital admissions. Anticipatory planning and palliative care should be carried ...
Source: Respiration - January 27, 2019 Category: Respiratory Medicine Source Type: research

Prevalence and Factors Contributing to Daytime and Nocturnal Hypoxemia in Chronic Heart Failure Patients
Conclusion: Most stable CHF patients suffer from nocturnal hypoxemia, while daytime hypoxemia is relatively rare. The degree of nocturnal hypoxemia depends on the severity of SDB. Hypoxemia phenotyping and severity could help better evaluate the need for appropriate therapy in CHF patients.Respiration (Source: Respiration)
Source: Respiration - January 17, 2019 Category: Respiratory Medicine Source Type: research