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Condition: Dilated Cardiomyopathy

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Total 155 results found since Jan 2013.

Surgical Techniques for Implanting the EVAHEART 2 Double Cuff Tipless Inflow Cannula
The EVAHEART 2 (Sun Medical Technology Research Corporation, Nagano, Japan) is an investigational centrifugal ventricular assist device in the United States, introduced a new type inflow, named “double cuff tipless” inflow cannula intended to mitigate the risks of cannula malposition and subsequent ischemic stroke events associated with thrombi around the inflow cannula. To achieve these performance benefits of the “tipless” design, however, it is crucial to adhere to the recommended surgical procedure. We introduced a polymer-based patient model that mimics a dilated cardiomyopathy apex for inflow cannula implanta...
Source: ASAIO Journal - November 1, 2019 Category: Medical Devices Tags: How to do it Article Source Type: research

Left Ventricular Stroke Work Index Associated with Outcome After Mitral Valve Surgery for Functional Regurgitation in Non-Ischemic Dilated Cardiomyopathy
The indications for mitral valve surgery in patients with advanced non-ischemic dilated cardiomyopathy and functional mitral regurgitation are still unclear. We reviewed our experience of mitral valve surgery in such patients and explored factors that were predictive of outcomes. Fifty-three consecutive patients with non-ischemic dilated cardiomyopathy and an ejection fraction
Source: Seminars in Thoracic and Cardiovascular Surgery - October 15, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Noriyuki Kashiyama, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Yoshiki Sawa, Osaka Cardiovascular Surgery Research (OSCAR) Group Tags: ADULT – Original Submission Source Type: research

A review of the epidemiology of atrial fibrillation in Sub ‐Saharan Africa
In conclusion, AF seems to have a higher prevalence in the general population than previously thought, and is mostly associa ted with hypertension, cardiomyopathy and rheumatic heart disease in SSA. It is associated with a high incidence of heart failure and stroke. The management of AF is suboptimal in SSA, especially with a low uptake of oral anticoagulation.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - October 8, 2019 Category: Cardiology Authors: Jean Jacques Noubiap, Ulrich Flore Nyaga Tags: COMPREHENSIVE REVIEWS Source Type: research

Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy
ConclusionsThe change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.
Source: General Thoracic and Cardiovascular Surgery - June 21, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Cardio-embolic stroke: Lessons from a single centre in Sub-Saharan Africa.
CONCLUSION: CES accounted for 1/4 of ischemic stroke with a high risk of early death and long-term recurrence. Atrial fibrillation was the leading cause of CES. The association of VKA and anti-platelet agent should be avoided to reduce early death during acute stroke. PMID: 31155304 [PubMed - as supplied by publisher]
Source: Revue Neurologique - June 4, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Endovascular treatment of stroke in children under 2 years with heart failure and ventricular assist device.
CONCLUSION: As a result of the difficulty in performing arterial puncture, the small vessel calibre and the limitation in the use of iodated contrast, there are certain limitations to endovascular treatment of strokes in children that can lead to complications. A multidisciplinary approach to managing such cases would be helpful. PMID: 31072251 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - May 12, 2019 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Is resynchronization therapy really efficient in laminopathy?
ConclusionCardiac resynchronization therapy seems to be less efficient in LMNA patients compared to usual implanted patients with other type of advanced cardiomyopathy. An impaired right ventricular stroke function seems to be the only predictive factor leading to poor response to CRT.
Source: Archives of Cardiovascular Diseases Supplements - March 22, 2019 Category: Cardiology Source Type: research

Converter domain mutations in myosin alter structural kinetics and motor function Molecular Biophysics
Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and F750L) to examine how altering specific structural transitions in the motor ATPase cycle can impair myosin mechanochemistry. The corresponding mutations in the human β-cardiac myosin gene are associated with hypertrophic and dilated cardiomyopathy, respectively. Despite similar steady-state actin-activated ATPase and unloaded in vitro motility–sliding velocities, both R712G and F750L were less able to overcome frictional loads measured in the loaded motility assay...
Source: Journal of Biological Chemistry - February 1, 2019 Category: Chemistry Authors: Laura K. Gunther, John A. Rohde, Wanjian Tang, Shane D. Walton, William C. Unrath, Darshan V. Trivedi, Joseph M. Muretta, David D. Thomas, Christopher M. Yengo Tags: Enzymology Source Type: research

Echocardiographic profile of Congolese hypertensive patients.
CONCLUSIONS: Echocardiographic profile of the Congolese hypertensive is quite various, left ventricular hypertrophy is the most predominant abnormality. Efficient management on the hypertension will lead to reduce its morbidity and mortality. PMID: 30290912 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - October 2, 2018 Category: Cardiology Authors: Ikama MS, Makani J, Nsitou BM, Mongo-Ngamami SF, Ellenga-Mbolla BF, Ondze-Kafata LI, Gombet TR, Kimbally-Kaky SG Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Timing of Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy.
CONCLUSIONS: Adding MRA to a standard medical regimen for NIDCM resulted in beneficial LV remodeling. The maximal beneficial remodeling was achieved with 12-16 months of MRA therapy. These results have implications for the timing of other advanced therapies, such as placing internal cardioverter-defibrillators. PMID: 30286821 [PubMed - in process]
Source: The American Journal of the Medical Sciences - September 1, 2018 Category: General Medicine Authors: Bradham WS, Bell SP, Huang S, Harrell FE, Adkisson DW, Lawson MA, Sawyer DB, Ooi H, Kronenberg MW Tags: Am J Med Sci Source Type: research

The heart in m.3243A > G carriers.
CONCLUSIONS: Cardiac involvement in m.3243A>G carriers has been only rarely systematically studied, which is perhaps why the incidence of cardiac diseases in MELAS is lower than would be expected. Myocardial abnormalities are much more frequent than arrhythmias or conduction defects. All symptomatic and asymptomatic m.3243A>G carriers should be systematically investigated for cardiac disease. PMID: 30128910 [PubMed - as supplied by publisher]
Source: Herz - August 23, 2018 Category: Cardiology Tags: Herz Source Type: research

Is there a role for tissue Doppler imaging in predicting thromboembolic risk? A challenging case report of dilated cardiomyopathy with intracardiac thrombus and recurrent stroke
No abstract available
Source: Journal of Cardiovascular Medicine - July 31, 2018 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

The contribution of systematic implementation of cardiovascular explorations for the detection of cardiac sources of embolism in patients with stroke: About 230  patients.
CONCLUSION: Cardiovascular explorations remain indispensable in the workup of all ischemic strokes even if their therapeutic effect is modest. The lacunar infarct out first at 34% followed by 32% of cardio embolic causes and atheroma of the neck vessels in approximately 16%. PMID: 29753425 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - May 9, 2018 Category: Cardiology Authors: Hadi A, Bendriss L, Khatouri A Tags: Ann Cardiol Angeiol (Paris) Source Type: research