Age-Dependence of Flow Homeostasis in the Left Ventricle

Age-Dependence of Flow Homeostasis in the Left Ventricle Yolanda Benito1, Pablo Martinez-Legazpi1*, Lorenzo Rossini2, Candelas Pérez del Villar1, Raquel Yotti1, Yolanda Martín Peinador3, Daniel Rodríguez-Pérez4, M. Mar Desco4, Constancio Medrano1, Jose Carlos Antoranz4, Francisco Fernández-Avilés1, Juan C. del Álamo2,5 and Javier Bermejo1 1Department of Cardiology, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón and CIBERCV, Madrid, Spain 2Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA, United States 3Centro de Salud Goya, Dirección Asistencial Centro, Atención Primaria de Madrid, Madrid, Spain 4Department of Mathematical Physics and Fluids, Facultad de Ciencias, Universidad Nacional de Educación a Distancia, Madrid, Spain 5Institute for Engineering in Medicine, University of California, San Diego, La Jolla, CA, United States Background: Intracardiac flow homeostasis requires avoiding blood stasis and platelet activation during its transit through the cardiac chambers. However, the foundations of intraventricular blood washout and its exposure to shear stresses have been poorly addressed. We aimed to characterize and quantify these features in a wide population of healthy subjects and assess the ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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