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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Phosphoglycerate mutase 1 knockdown inhibits prostate cancer cell growth, migration, and invasion.
Abstract Phosphoglycerate mutase 1 (PGAM1) is upregulated in many cancer types and involved in cell proliferation, migration, invasion, and apoptosis. However, the relationship between PGAM1 and prostate cancer is poorly understood. The present study investigated the changes in PGAM1 expression in prostate cancer tissues compared with normal prostate tissues and examined the cellular function of PGAM1 and its relationship with clinicopathological variables. Immunohistochemistry and Western blotting revealed that PGAM1 expression was upregulated in prostate cancer tissues and cell lines. PGAM1 expression was associ...
Source: Asian Journal of Andrology - December 22, 2017 Category: Urology & Nephrology Authors: Wen YA, Zhou BW, Lv DJ, Shu FP, Song XL, Huang B, Wang C, Zhao SC Tags: Asian J Androl Source Type: research

Zhang L, Zhang Q, Liu S, et  al. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney Int. 2017;92:140–153
The above-mentioned article, in Figure  5h, the same fluorescence images presented in the HG group were mistakenly present in the HG+Con –siRNA group. The corrected image is as follows:
Source: Kidney International - December 29, 2017 Category: Urology & Nephrology Tags: Corrigendum Source Type: research

Pd03-07 rna interference of hepatic lactate dehydrogenase reduces urinary oxalate in a mouse model of primary hyperoxaluria type 1
Endogenous oxalate synthesis primarily occurs via lactate dehydrogenase (LDH) activity in the liver. Liver specific RNAi therapeutics are currently in clinical trials for a number of diseases. Previous work using RNAi against liver glycolate oxidase demonstrated reduction of urinary oxalate in the Agxt knock out mouse, a model for primary hyperoxaluria Type 1 (PH1). Our objective was to evaluate the effects of siRNA knock down of liver LDHA in wild type (Wt) and PH1 mouse model (Agxt knock out (KO)).
Source: The Journal of Urology - April 1, 2018 Category: Urology & Nephrology Authors: Kyle Wood, John Knight, Dean Assimos, Ross Holmes Tags: Stone Disease: Basic Research & Pathophysiology I Source Type: research

Gpr97 Exacerbates AKI by Mediating Sema3A Signaling
Conclusions Gpr97 is an important mediator of AKI, and pharmacologic targeting of Gpr97-mediated Sema3A signaling at multiple levels may provide a novel approach for the treatment of AKI.
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Fang, W., Wang, Z., Li, Q., Wang, X., Zhang, Y., Sun, Y., Tang, W., Ma, C., Sun, J., Li, N., Yi, F. Tags: Basic Research Source Type: research

The Role of Palladin in Podocytes
Conclusions Palladin has an important role in podocyte function in vitro and in vivo.
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Artelt, N., Ludwig, T. A., Rogge, H., Kavvadas, P., Siegerist, F., Blumenthal, A., van den Brandt, J., Otey, C. A., Bang, M.-L., Amann, K., Chadjichristos, C. E., Chatziantoniou, C., Endlich, K., Endlich, N. Tags: Basic Research Source Type: research

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.
In conclusion, deletion of exon 9 from Cul3 generates a protein that is itself ubiquitin ligase-defective, but also capable of enhanced autophagocytic KLHL3 degradation, thereby exerting dominant-negative effects on the WT-allele. PMID: 29897280 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - June 13, 2018 Category: Urology & Nephrology Authors: Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH Tags: Am J Physiol Renal Physiol Source Type: research

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification
Conclusion: Silencing of SHMT1 promotes osteo-/chondrogenic signaling in VSMCs, at least in part, by inducing cellular oxidative stress. It thus aggravates phosphate-induced calcification of VSMCs. The present findings support a regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease.Kidney Blood Press Res 2018;43:1212 –1221
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal  fibrosis
The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, in various models of kidney disease induced by unilateral ureteral obstruction, adriamycin or ischemia/reperfusion injury. In  vitro, forced expression of CB2 or treatment with a CB2 agonist was sufficient to trigger matrix gene expression, whereas knockdown of CB2 by siRNA abolished transforming growth factor...
Source: Kidney International - August 6, 2018 Category: Urology & Nephrology Authors: Lili Zhou, Shan Zhou, Peng Yang, Yuan Tian, Zhiwei Feng, Xiang-Qun Xie, Youhua Liu Tags: Basic Research Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells.
Abstract Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by rapamycin...
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Liu J, Zhu W, Jiang CM, Feng Y, Xia YY, Zhang QY, Xu PF, Zhang M Tags: Am J Nephrol Source Type: research

Effect of platelet ‐derived growth factor‐BB on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells
Abstract We explored whether platelet ‐derived growth factor (PDGF)‐BB regulates corpus cavernosum smooth muscle cell gap junctions and can ameliorate erectile dysfunction and how it modulates connexin43 (CX43) after bilateral cavernous neurectomy. Primary cultured rat corpus cavernosum smooth muscle cells were treated with PDGF‐B B with or without a PDGFR inhibitor, Akt siRNA or the depletion or promotion of β‐catenin. PDGF‐BB improved CCSMCs gap junction coupling and increased CX43 and PDGFRβ expression; inhibition of PDGFR activity down‐regulated CX43 and decreased Akt and nuclear β‐catenin. Knockdown o...
Source: Andrologia - November 23, 2018 Category: Urology & Nephrology Authors: Fan Zhao, Junfeng Yan, Jianfeng Zhao, Bing Shi, Miaoyong Ye, Xiaojun Huang, Bo Yu, Bodong Lv, Wenjie Huang Tags: ORIGINAL ARTICLE Source Type: research

Identification of NFAT5 as a transcriptional regulator of the EDN1gene in collecting duct.
Abstract The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na+and water reabsorption. Recent studies suggest that IMCD ET-1 production is enhanced by extracellular hypertonicity as can occur during high salt intake. While NFAT5 has been implicated in the IMCD ET-1 hypertonicity response, no studies in any cell type have identified NFAT5 as a transcriptional regulator of the EDN1gene; the currently study examined this using a mouse IMCD cell line (IMCD3). Media hypertonicity increased IMCD3 ET-1 mRNA in a dose- and time-dependent ...
Source: Am J Physiol Renal P... - January 9, 2019 Category: Urology & Nephrology Authors: Lakshmipathi J, Wheatley W, Kumar A, Mercenne G, Rodan AR, Kohan DE Tags: Am J Physiol Renal Physiol Source Type: research

Blockade of ERK1/2 by U0126 alleviates uric acid induced EMT and tubular cell injury in the rats with hyperuricemic nephropathy.
In this study, we showed that hyperuricemic injury induced EMT as characterized by down-regulation of E-cadherin and up-regulation of Vimentin and Snail1 in a rat model of HN. This was coincident with epithelial cells arrested at the G2/M phase of cell cycle, activation of Notch1/Jagged-1 and Wnt/β-catenin signaling pathways, and upregulation of matrix metalloproteinases 2 (MMP2) and MMP9. Administration of U0126, a selective inhibitor of ERK1/2, blocked all these responses. U0126 was also effective in inhibiting renal tubular cell injury as shown by decreased expression of lipocalin-2 (Lcn2) and kidney injury molecule-1 ...
Source: Am J Physiol Renal P... - January 16, 2019 Category: Urology & Nephrology Authors: Tao M, Shi Y, Tang L, Wang Y, Fang L, Jiang W, Lin T, Qiu A, Zhuang S, Liu N Tags: Am J Physiol Renal Physiol Source Type: research

Estrogen-Related Receptor α Mediates Puromycin Aminonucleoside-induced Mesangial Cell apoptosis and Inflammatory Injury.
Abstract Glomerular diseases are the leading causes of chronic kidney disease and mesangial cells (MCs) were demonstrated to be involved in the pathogenesis. Puromycin aminonucleoside (PAN) is a nephrotoxic drug that induced glomerular injury with elusive mechanisms. The present study is undertaken to investigate the role of PAN in MC apoptosis, as well as the underlying mechanism. Here we found that PAN induced MC apoptosis accompanied by the declined cell viability and enhanced inflammatory response. The apoptosis was further evidenced by the increments of BAX and Caspase-3 expression. In line with the apoptotic...
Source: Am J Physiol Renal P... - January 30, 2019 Category: Urology & Nephrology Authors: Gong W, Song J, Chen X, Li S, Yu J, Xia W, Ding G, Zhang Y, Jia Z, Zhang A, Huang S Tags: Am J Physiol Renal Physiol Source Type: research

RPS7 promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer.
CONCLUSIONS: RPS7 is a newly verified tumor promoter in PCa, and promotes cell migration by targeting epithelial-to-mesenchymal transition pathway. Thus, inhibition of RPS7-epithelial to-mesenchymal transition signaling might represent a prospective approach toward limiting prostate tumor progression. PMID: 30737160 [PubMed - as supplied by publisher]
Source: Urologic Oncology - February 5, 2019 Category: Urology & Nephrology Authors: Wen Y, An Z, Qiao B, Zhang C, Zhang Z Tags: Urol Oncol Source Type: research

Loss of reticulocalbin 2 lowers blood pressure and restrains angiotensin II-induced hypertension in vivo.
Abstract Hypertension affects over one billion people worldwide and increases risk for heart failure, stroke and chronic kidney disease. Despite high prevalence and devastating impact, its etiology still remains poorly understood for most hypertensive cases. Rcn2, encoding reticulocalbin 2, is a candidate gene for atherosclerosis we previously demonstrated in mice. Here we identified Rcn2 as a novel regulator of blood pressure in mice. Rcn2 was dramatically upregulated in arteries undergoing structural remodeling. Deletion of Rcn2 lowered basal blood pressure and attenuated angiotensin II-induced hypertension in C...
Source: Am J Physiol Renal P... - April 2, 2019 Category: Urology & Nephrology Authors: Li J, Cechova S, Wang L, Isakson BE, Le T, Shi W Tags: Am J Physiol Renal Physiol Source Type: research