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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Re: Anisamide-Targeted Cyclodextrin Nanoparticles for siRNA Delivery to Prostate Tumours in Mice
J. Guo, J. R. Ogier, S. Desgranges, R. Darcy and C. O'Driscoll School of Pharmacy, University College Cork, Cork, Ireland
Source: The Journal of Urology - April 1, 2013 Category: Urology & Nephrology Authors: Anthony Atala Tags: Uro-Science Source Type: research

Hyper‐expression of PAX2 in human metastatic prostate tumors and its role as a cancer promoter in an in vitro invasion model
CONCLUSIONSOur data suggested that PAX2 hyper‐expression promotes the development of the metastatic state in prostate cancer cells, presumably through upregulating the expression of cell membrane proteins. Prostate 9999: 1–10, 2013. © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 14, 2013 Category: Urology & Nephrology Authors: Takashi Ueda, Saya Ito, Takumi Shiraishi, Prakash Kulkarni, Akihisa Ueno, Hideo Nakagawa, Yasunori Kimura, Fumiya Hongo, Kazumi Kamoi, Akihiro Kawauchi, Tsuneharu Miki Tags: Original Article Source Type: research

The over‐expression of Pim‐2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B
CONCLUSIONPim‐2 was over‐expressed in PCA cell lines and tissues. It may inhibit the apoptosis of PCA cells through phosphorylating eIF4B, thus promote the tumorigenesis of PCA. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 27, 2013 Category: Urology & Nephrology Authors: Ke Ren, Xin Gou, Mingzhao Xiao, Ming Wang, Chaodong Liu, Zhaobing Tang, Weiyang He Tags: Original Article Source Type: research

NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma
Conclusions: Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that NOTCH1 could regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines. These might provide a basis for the designing new therapeutic strategies for CCRCC.
Source: Urologic Oncology: Seminars and Original Investigations - October 13, 2011 Category: Urology & Nephrology Authors: Shangwen Liu, Xin Ma, Qing Ai, Qingbo Huang, Taoping Shi, Mingyang Zhu, Baojun Wang, Xu Zhang Tags: Clinical - Kidney Source Type: research

15-Deoxy-Δ-Prostaglandin J2 Modulates Lipopolysaccharide-Induced Chemokine Expression by Blocking Nuclear Factor-κB Activation via Peroxisome Proliferator Activated Receptor-γ-Independent Mechanism in Renal Tubular Epithelial Cells.
Conclusion: Collectively, these results suggest that 15d-PGJ2 exerts anti-inflammatory actions on HK-2 cells by attenuating chemokines expression. 15d-PGJ2 inhibits chemokines expression via a PPAR-γ-independent way, which is related to block NF-κB pathway. Since NF-κB is an important regulator of the response of HPTECs to injury, PPAR-γ agonists may represent a key pharmacological target for ameliorating inflammation-associated tubulointerstitial fibrosis. © 2013 S. Karger AG, Basel. PMID: 23887394 [PubMed - as supplied by publisher]
Source: Nephron Experimental Nephrology - July 24, 2013 Category: Urology & Nephrology Authors: Lu Y, Zhou Q, Zhong F, Guo S, Hao X, Li C, Wang W, Chen N Tags: Nephron Exp Nephrol Source Type: research

High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1
Activation of the transcription factor NFAT5 by high NaCl involves changes in phosphorylation. By siRNA screening, we previously found that protein targeting to glycogen (PTG), a regulatory subunit of protein phosphatase1 (PP1), contributes to regulation of high NaCl-induced NFAT5 transcriptional activity. The present study addresses the mechanism involved. We find that high NaCl-induced inhibition of PTG elevates NFAT5 activity by increasing NFAT5 transactivating activity, protein abundance, and nuclear localization. PTG acts via a catalytic subunit PP1. PTG associates physically with PP1, and NaCl reduces both this assoc...
Source: AJP: Renal Physiology - August 1, 2013 Category: Urology & Nephrology Authors: Zhou, X., Wang, H., Burg, M. B., Ferraris, J. D. Tags: ARTICLES Source Type: research

Aldosterone Reprograms Promoter Methylation To Regulate αENaC Transcription In Collecting Duct.
Abstract Aldosterone increases tubular sodium absorption largely by increasing epithelial Na(+) channel (ENaC) α transcription in collecting duct principal cells. How aldosterone reprograms basal (αENaC) transcription to high-level activity in the collecting duct is incompletely understood. Promoter methylation, a covalent, but reversible epigenetic process, has been implicated in the control of gene expression in health and disease. We investigated the role of promoter methylation/demethyation in epigenetic control of basal and aldosterone-stimulated (αENaC) transcription in mIMCD3 collecting duct cells. Bisul...
Source: Am J Physiol Renal P... - August 7, 2013 Category: Urology & Nephrology Authors: Yu Z, Kong Q, Kone BC Tags: Am J Physiol Renal Physiol Source Type: research

NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma
Conclusions: Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that NOTCH1 could regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines. These might provide a basis for the designing new therapeutic strategies for CCRCC.
Source: Urologic Oncology: Seminars and Original Investigations - October 13, 2011 Category: Urology & Nephrology Authors: Shangwen Liu, Xin Ma, Qing Ai, Qingbo Huang, Taoping Shi, Mingyang Zhu, Baojun Wang, Xu Zhang Tags: Clinical - Kidney Source Type: research

Evaluation of ERG responsive proteome in prostate cancer
CONCLUSIONSThis study delineates the global proteome for prostate tumors stratified by ERG expression status. The ERP data confirm the functions of ERG in inhibiting cell differentiation and activating cell growth, and identify potentially novel biomarkers and therapeutic targets. Prostate 9999: XX–XX, 2013. © 2013 Wiley Periodicals, Inc.
Source: The Prostate - September 21, 2013 Category: Urology & Nephrology Authors: Shyh‐Han Tan, Bungo Furusato, Xueping Fang, Fang He, Ahmed A. Mohamed, Nicholas B. Griner, Kaneeka Sood, Sadhvi Saxena, Shilpa Katta, Denise Young, Yongmei Chen, Taduru Sreenath, Gyorgy Petrovics, Albert Dobi, David G. McLeod, Isabell A. Sesterhenn, Sat Tags: Original Article Source Type: research

Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells
CONCLUSIONSThis study demonstrates that the autocrine IL‐6 pathway induces enzalutamide resistance in prostate cancer cells via the constitutive activation of Stat3. Co‐targeting IL6‐Stat3 pathway with enzalutamide may be utilized for treatment of advanced prostate cancer. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - October 19, 2013 Category: Urology & Nephrology Authors: Chengfei Liu, Yezi Zhu, Wei Lou, Yuanyuan Cui, Christopher P. Evans, Allen C. Gao Tags: Original Article Source Type: research

Hypoxia-inducible factor-2{alpha} and TGF-{beta} signaling interact to promote normoxic glomerular fibrogenesis
Hypoxia-inducible factors (HIFs) are transcription factors consisting of an oxygen-sensitive α-subunit binding to a stable β-subunit. HIFs regulate multiple signaling pathways that could contribute to fibrogenesis, supporting their potential role in hypoxia-mediated renal fibrosis. We previously reported that HIF-1 is upregulated and required for transforming growth factor (TGF)-β induction of collagen in renal tubular cells. Here, we performed in vitro and in vivo studies of potential glomerular crosstalk between TGF-β and normoxic HIF signaling. HIF-α has two major isoforms, HIF-1α and HI...
Source: AJP: Renal Physiology - November 1, 2013 Category: Urology & Nephrology Authors: Hanna, C., Hubchak, S. C., Liang, X., Rozen-Zvi, B., Schumacker, P. T., Hayashida, T., Schnaper, H. W. Tags: ARTICLES Source Type: research

Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development
Conclusions: Slug elevates in invasive or metastatic bladder cancer and plays a critical role in EMT via control of cadherin switch. Slug may be a potential marker or target for improving the diagnosis and treatment of muscle-invasive bladder cancers.
Source: Urologic Oncology: Seminars and Original Investigations - March 16, 2012 Category: Urology & Nephrology Authors: Kaijie Wu, Jin Zeng, Jiancheng Zhou, Jinhai Fan, Yule Chen, Zhiqiang Wang, TingTing Zhang, Xinyang Wang, Dalin He Tags: Laboratory - Bladder Source Type: research

Skp2 regulates androgen receptor through ubiquitin‐mediated degradation independent of Akt/mTOR pathways in prostate cancer
CONCLUSIONSThe results indicate that Skp2 is an E3 ligase for proteasome‐dependent AR degradation, and K847 on AR is the recognition site for Skp2‐mediated ubiquitination. Our findings reveal an essential role of Skp2 in AR signaling. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - December 19, 2013 Category: Urology & Nephrology Authors: Bo Li, Wenfu Lu, Qing Yang, Xiuping Yu, Robert J. Matusik, Zhenbang Chen Tags: Original Article Source Type: research

ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cells
CONCLUSIONOur findings define a key role for ERG/SOX4 in the development of a subset of PCa and highlight the clinical importance of identifying molecularly defined tumor subgroups. Prostate © 2014 Wiley Periodicals, Inc.
Source: The Prostate - January 16, 2014 Category: Urology & Nephrology Authors: Lin Wang, Yanjiang Li, Xiaoqing Yang, Huiqing Yuan, Xiangzhi Li, Mei Qi, Yannicca W.Y. Chang, Chunni Wang, WeiWei Fu, Muyi Yang, Juan Zhang, Bo Han Tags: Original Article Source Type: research

A ROS/STAT3/HIF‐1α signaling cascade mediates EGF‐induced TWIST1 expression and prostate cancer cell invasion
CONCLUSIONSWe demonstrate a mechanism by which EGF promotes prostate cancer cell progression through a ROS/STAT3/HIF‐1α/TWIST1/N‐cadherin signaling cascade, providing novel biomarkers and promising therapeutic targets for prostate cancer cell progression. Prostate © 2014 Wiley Periodicals, Inc.
Source: The Prostate - January 16, 2014 Category: Urology & Nephrology Authors: Kyung Hwa Cho, Moon Jung Choi, Kang Jin Jeong, Jeong Jin Kim, Min Ha Hwang, Shang Cheul Shin, Chang Gyo Park, Hoi Young Lee Tags: Original Article Source Type: research