Filtered By:
Specialty: Urology & Nephrology
This page shows you your search results in order of relevance. This is page number 13.
Order by Relevance | Date
Total 430 results found since Jan 2013.
Blockade of interleukin‐8 receptor signalling inhibits cyst development in vitro, via suppression of cell proliferation in autosomal polycystic kidney disease
ConclusionThese results suggest that IL‐8 and its signalling molecules could be new biomarkers and a therapeutic target of ADPKD.
Source: Nephrology - July 25, 2014 Category: Urology & Nephrology Authors: Eun Ji Lee, Seon Ah Song, Hyo Won Mun, Kyung Hyun Yoo, Soo Young Choi, Eun Young Park, Jong Hoon Park Tags: Original Article Source Type: research
Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes
CONCLUSIONAR variants could contribute to PCa progression through induction of EMT and acquisition of stem cell characteristics, which could be attenuated by BR‐DIM, suggesting that BR‐DIM could become a promising agent for the prevention of CRPC and/or for the treatment of PCa. Prostate © 2014 Wiley Periodicals, Inc.
Source: The Prostate - October 13, 2014 Category: Urology & Nephrology Authors: Dejuan Kong, Seema Sethi, Yiwei Li, Wei Chen, Wael A. Sakr, Elisabeth Heath, Fazlul H. Sarkar Tags: Original Article Source Type: research
PKCα contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAP kinase ERK1/2.
Abstract
High NaCl in the renal medullary interstitial fluid powers concentration of the urine, but can damage cells. The transcription factor NFAT5 activates expression of osmoprotective genes. We studied whether PKCα contributes to activation of NFAT5. PKCα protein abundance is greater in the renal medulla than in the cortex. Knockout of PKCα reduces NFAT5 protein abundance and expression of its target genes in the inner medulla. In HEK293 cells, high NaCl increases PKCα activity and siRNA-mediated knockdown of PKCα attenuates high NaCl-induced NFAT5 transcriptional activity. Expression of ERK1/2 protein an...
Source: Am J Physiol Renal P... - November 12, 2014 Category: Urology & Nephrology Authors: Wang H, Ferraris JD, Klein JD, Sands JM, Burg MB, Zhou X Tags: Am J Physiol Renal Physiol Source Type: research
An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat.
Abstract
Despite the fact that the phenomenon of capacitation was discovered over half century ago and much progress has been made in identifying sperm events involved in capacitation, few specific molecules of epididymal origin have been identified as being directly involved in this process in vivo. Previously, our group cloned and characterized a carboxyl esterase gene Ces5a in the rat epididymis. The CES5A protein is mainly expressed in the corpus and cauda epididymidis and secreted into the corresponding lumens. Here, we report the function of CES5A in sperm maturation. By local injection of Lentivirus-mediate...
Source: Asian Journal of Andrology - November 28, 2014 Category: Urology & Nephrology Authors: Ru YF, Xue HM, Ni ZM, Xia D, Zhou YC, Zhang YL Tags: Asian J Androl Source Type: research
Physical and Functional Links between Anion Exchanger-1 and Sodium Pump
Anion exchanger-1 (AE1) mediates chloride-bicarbonate exchange across the plasma membranes of erythrocytes and, via a slightly shorter transcript, kidney epithelial cells. On an omnivorous human diet, kidney AE1 is mainly active basolaterally in α-intercalated cells of the collecting duct, where it is functionally coupled with apical proton pumps to maintain normal acid-base homeostasis. The C-terminal tail of AE1 has an important role in its polarized membrane residency. We have identified the β1 subunit of Na+,K+-ATPase (sodium pump) as a binding partner for AE1 in the human kidney. Kidney AE1 and β1 colo...
Source: Journal of the American Society of Nephrology : JASN - January 30, 2015 Category: Urology & Nephrology Authors: Su, Y., Al-Lamki, R. S., Blake-Palmer, K. G., Best, A., Golder, Z. J., Zhou, A., Karet Frankl, F. E. Tags: Basic Research Source Type: research
Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis
In conclusion, AMPK may serve as a promising therapeutic target through reducing ER stress and renal fibrosis.
Source: AJP: Renal Physiology - February 1, 2015 Category: Urology & Nephrology Authors: Kim, H., Moon, S. Y., Kim, J.-S., Baek, C. H., Kim, M., Min, J. Y., Lee, S. K. Tags: ARTICLES Source Type: research
Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome
Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome
Kidney International 87,
535 (March 2015). doi:10.1038/ki.2014.351
Authors: Motonobu Nakamura, Osamu Yamazaki, Ayumi Shirai, Shoko Horita, Nobuhiko Satoh, Masashi Suzuki, Yoshifumi Hamasaki, Eisei Noiri, Haruki Kume, Yutaka Enomoto, Yukio Homma & George Seki
Source: Kidney International - February 27, 2015 Category: Urology & Nephrology Authors: Motonobu NakamuraOsamu YamazakiAyumi ShiraiShoko HoritaNobuhiko SatohMasashi SuzukiYoshifumi HamasakiEisei NoiriHaruki KumeYutaka EnomotoYukio HommaGeorge Seki Tags: insulin resistance IRS1 IRS2 NBCe1 proximal tubule siRNA Source Type: research
KDM1A triggers androgen‐induced miRNA transcription via H3K4me2 demethylation and DNA oxidation
ConclusionOur work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen‐dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - March 2, 2015 Category: Urology & Nephrology Authors: Shu Yang, Jiyuan Zhang, Yalong Zhang, Xuechao Wan, Congzhe Zhang, Xiaohui Huang, Wenhua Huang, Honglei Pu, Chaohan Pei, Hai Wu, Yan Huang, Shengdong Huang, Yao Li Tags: Original Article Source Type: research
Tankyrase-mediated {beta}-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells
We examined whether tankyrase plays a role in AVP-induced AQP2 regulation via ADP-ribosylation of G protein-α (Gα) and/or β-catenin-mediated transcription of AQP2. RT-PCR and immunoblotting analysis revealed the mRNA and protein expression of tankyrase in mouse kidney and mouse collecting duct mpkCCDc14 cells. dDAVP-induced AQP2 upregulation was attenuated in mpkCCDc14 cells under the tankyrase inhibition by XAV939 treatment or small interfering (si) RNA knockdown. Fluorescence resonance energy transfer image analysis, however, revealed that XAV939 treatment did not affect dDAVP- or forskolin-induced PKA a...
Source: AJP: Renal Physiology - March 1, 2015 Category: Urology & Nephrology Authors: Jung, H. J., Kim, S.-Y., Choi, H.-J., Park, E.-J., Lim, J.-S., Frokiaer, J., Nielsen, S., Kwon, T.-H. Tags: ARTICLES Source Type: research
Impairment of HNF4α Binding to stim1 Promoter Contributes to High Glucose-induced Upregulation of STIM1 Expression in Glomerular Mesangial Cells.
Abstract
The present study was carried out to investigate if hepatic nuclear factor 4α (HNF4α) contributed to high glucose-induced increase in STIM1 protein abundance in glomerular mesangial cells (MCs). Western blot and immunofluorescence studies showed HNF4α expression in MCs. Knockdown of HNF4α using siRNA approach significantly increased mRNA expression levels of both STIM1 and Orai1, and protein expression level of STIM1 in cultured human MCs. Consistently, over expression of HNF4α reduced expressed STIM1 protein expression in HEK293 cells. Furthermore, high glucose treatment did not significantly change...
Source: Am J Physiol Renal P... - March 18, 2015 Category: Urology & Nephrology Authors: Wang Y, Chaudhari S, Ren Y, Ma R Tags: Am J Physiol Renal Physiol Source Type: research
Mp34-04 inhibition of glycolate oxidase reduces urinary oxalate excretion in a mouse model of primary hyperoxaluria type 1
The objective of this study was to test whether the knock down of glycolate oxidase (GO) using siRNA treatment in a mouse model of PH1 reduces oxalate synthesis.
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Xingsheng Li, John Knight, Sonia Fargue, William Querbes, Kevin Fitzgerald, Ross P. Holmes Tags: Stone Disease: Basic Research II Source Type: research
Albumin impairs renal tubular tight junctions via targeting the NLRP3 inflammasome
Proteinuria is, not only a hallmark of glomerular disease, but also a contributor to kidney injury. However, its pathogenic mechanism is still elusive. In the present study, the effects of albumin on renal tubular tight junctions and the potential molecular mechanisms of those effects were investigated. In mouse proximal tubular cells (mPTCs), albumin treatment resulted in a significant loss of the cellular tight junction proteins zonula occludens-1 (ZO-1) and claudin-1 in a time- and dose-dependent manner, indicating a severe impairment of the tight junctions. On the basis of our previous study showing that albumin stimul...
Source: AJP: Renal Physiology - May 1, 2015 Category: Urology & Nephrology Authors: Zhuang, Y., Hu, C., Ding, G., Zhang, Y., Huang, S., Jia, Z., Zhang, A. Tags: ARTICLES Source Type: research
HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells.
CONCLUSION: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy. © 2015 S. Karger AG, Basel.
PMID: 25924590 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - April 28, 2015 Category: Urology & Nephrology Authors: Cheng M, Liu H, Zhang D, Liu Y, Wang C, Liu F, Chen J Tags: Am J Nephrol Source Type: research
Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis
ConclusionDownregulation of Prx1 occurred in renal tubular epithelial cells of UUO rats and patients with obstructive nephropathy. Prx1 may alleviate the pathogenesis by inhibiting H2O2‐induced apoptosis via inhibiting the p38 MAPK pathway. Prx1 may represent a useful target for a protective therapy towards renal tubulointerstitial fibrosis.
Source: Nephrology - May 20, 2015 Category: Urology & Nephrology Authors: Wenjuan Mei, Zhangzhe Peng, Miaomiao Lu, Chunyan Liu, Zhenghao Deng, Yun Xiao, Jishi Liu, Ying He, Qiongjing Yuan, Xiangning Yuan, Damu Tang, Huixiang Yang, Lijian Tao Tags: Original Article Source Type: research
Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is associated with oxidative stress and mitochondrial injury. Myo-inositol oxygenase (MIOX), a tubular-specific enzyme, modulates redox imbalance and apoptosis in tubular cells in diabetes, but these mechanisms remain unclear. We investigated the role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose (HG) ambience or a diabetic state. HK-2 or LLC-PK1 cells subjected to HG exhibited an upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and alte...
Source: Journal of the American Society of Nephrology : JASN - May 29, 2015 Category: Urology & Nephrology Authors: Zhan, M., Usman, I. M., Sun, L., Kanwar, Y. S. Tags: Basic Research Source Type: research
