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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Elevated PTH induces endothelial to chondrogenic transition in aortic endothelial cells.
Abstract Previous studies have shown that increased parathyroid hormone (PTH) due to secondary hyperparathyroidism in chronic kidney disease accelerates the arteriosclerotic fibrosis and calcification. Although the underlying mechanisms remain largely unknown, endothelial cells (ECs) have recently been demonstrated to participate in calcification in part by providing chondrogenic cells via the endothelial-to-mesenchymal transition (EndMT). Therefore, this study aimed to investigate whether elevated PTH could induce endothelial to chondrogenic transition in aortic ECs and to determine the possible underlying signal...
Source: Am J Physiol Renal P... - August 30, 2016 Category: Urology & Nephrology Authors: Wu M, Zhang JD, Tang RN, Crowley SD, Liu H, Lv LL, Ma KL, Liu BC Tags: Am J Physiol Renal Physiol Source Type: research

TGF ‐β Effects on Prostate Cancer Cell Migration and Invasion Require FosB
CONCLUSIONOur data suggest that FosB is required for migration and invasion in prostate cancer cells. We also conclude that TGF‐β1 effect on prostate cancer cell migration and invasion may be mediated through the induction of FosB. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - September 8, 2016 Category: Urology & Nephrology Authors: Cach étne S.X. Barrett, Ana C. Millena, Shafiq A. Khan Tags: Original Article Source Type: research

Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters
CONCLUSIONSNew CRPC cell line with increased expression of y+LAT2 as a leucine transporter was established in vitro. Anti‐leucine transporter therapy could be an important option against prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - October 3, 2016 Category: Urology & Nephrology Authors: Hideo Otsuki, Toru Kimura, Takashi Yamaga, Takeo Kosaka, Jun ‐ichi Suehiro, Hiroyuki Sakurai Tags: Original Article Source Type: research

Depletion of vacuolar protein sorting-associated protein 35 is associated with increased lysosomal degradation of aquaporin-2.
Abstract Carboxyl-terminus of AQP2 (AQP2c) undergoes post-translational modifications, including phosphorylation and ubiquitination, for the regulation of aquaporin-2 (AQP2) translocation and protein abundance. We aimed to identify novel proteins interacting with AQP2c. Recombinant AQP2c protein was made in E. coli BL21 (DE3) by exploiting the pET32 TrxA fusion system. Lysates of rat kidney inner medullary collecting duct (IMCD) tubule suspensions interacted with rat AQP2c bound to Ni(2+)-resin were subjected to LC-MS/MS proteomic analysis. Potential interacting proteins were identified, including vacuolar protein...
Source: Am J Physiol Renal P... - October 11, 2016 Category: Urology & Nephrology Authors: Lee MS, Choi HJ, Park EJ, Park HJ, Kwon TH Tags: Am J Physiol Renal Physiol Source Type: research

ILK and Cytoskeletal Architecture: An Important Determinant of AQP2 Recycling and Subsequent Entry into the Exocytotic Pathway.
Abstract Within the past decade tremendous efforts have been made to understand the mechanism behind aquaporin-2 (AQP2) water channel trafficking and recycling, in order to open a path towards effective diabetes insipidus therapeutics. A recent study has shown that Integrin-Linked Kinase (ILK) conditional-knockdown mice developed polyuria along with decreased expression of AQP2. To understand whether ILK also regulates AQP2 trafficking in kidney tubular cells, we performed in vitro analysis using LLCPK1 cells stably expressing rat AQP2 (LLC-AQP2 cells). Upon treatment of LLC-AQP2 cells with ILK inhibitor cpd22 and...
Source: Am J Physiol Renal P... - October 18, 2016 Category: Urology & Nephrology Authors: Mamuya FA, Cano-Peñalver JL, Li WU, Rodriguez-Puyol D, Rodríguez-Puyol M, Brown D, de Frutos S, Lu HJ Tags: Am J Physiol Renal Physiol Source Type: research

Depletion of vacuolar protein sorting-associated protein 35 is associated with increased lysosomal degradation of aquaporin-2
The carboxyl terminus of aquaporin-2 (AQP2c) undergoes posttranslational modifications, including phosphorylation and ubiquitination, in the process of regulating aquaporin-2 (AQP2) translocation and protein abundance. We aimed to identify novel proteins interacting with AQP2c. Recombinant AQP2c protein was made in Escherichia coli BL21 (DE3) cells by exploiting the pET32 TrxA fusion system. Lysates of rat kidney inner medullary collecting duct (IMCD) tubule suspensions interacted with rat AQP2c bound to Ni2+-resin were subjected to LC-MS/MS proteomic analysis. Potential interacting proteins were identified, including vacu...
Source: AJP: Renal Physiology - November 30, 2016 Category: Urology & Nephrology Authors: Lee, M. S., Choi, H.-J., Park, E.-J., Park, H.-J., Kwon, T.-H. Tags: ARTICLES Source Type: research

ILK and cytoskeletal architecture: an important determinant of AQP2 recycling and subsequent entry into the exocytotic pathway
Within the past decade tremendous efforts have been made to understand the mechanism behind aquaporin-2 (AQP2) water channel trafficking and recycling, to open a path toward effective diabetes insipidus therapeutics. A recent study has shown that integrin-linked kinase (ILK) conditional-knockdown mice developed polyuria along with decreased AQP2 expression. To understand whether ILK also regulates AQP2 trafficking in kidney tubular cells, we performed in vitro analysis using LLCPK1 cells stably expressing rat AQP2 (LLC-AQP2 cells). Upon treatment of LLC-AQP2 cells with ILK inhibitor cpd22 and ILK-siRNA, we observed increas...
Source: AJP: Renal Physiology - December 11, 2016 Category: Urology & Nephrology Authors: Mamuya, F. A., Cano-Penalver, J. L., Li, W., Rodriguez Puyol, D., Rodriguez Puyol, M., Brown, D., de Frutos, S., Lu, H. A. J. Tags: CALL FOR PAPERS Source Type: research

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark of ADPKD is increased epithelial proliferation, which has been proposed to be due to atypical signaling including abnormal JAK-STAT activity. However, the relative contribution of JAK-STAT family members in promoting proliferation in ADPKD is unknown. Here, we present siRNA JAK-STAT –focused screens discovering a previously unknown proliferative role for multiple JAK-STAT components (including STAT1, STAT2, STAT4, STAT5a, and STAT5b).
Source: Kidney International - January 15, 2017 Category: Urology & Nephrology Authors: Maria Fragiadaki, Morgane Lannoy, Madeleine Themanns, Barbara Maurer, Wouter N. Leonhard, Dorien J.M. Peters, Richard Moriggl, Albert C.M. Ong Tags: Basic Research Source Type: research

Androgen Receptor Splice Variants Are Not Substrates of Nonsense ‐Mediated Decay
CONCLUSIONThis study eliminates a possible mechanism of regulation of certain AR variants. Future research into the regulation of AR variants should focus on other mechanisms to better understand the origin of these variants and to possibly inhibit their expression for the resensitization of resistant cancers. Prostate. © 2017 Wiley Periodicals, Inc.
Source: The Prostate - February 22, 2017 Category: Urology & Nephrology Authors: Atinuke S. Ajiboye, David Esopi, Srinivasan Yegnasubramanian, Samuel R. Denmeade Tags: Original Article Source Type: research

Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals
CONCLUSIONSSHARPIN enhances the metastasis of prostate cancer and impair patient survivals. Prostate. © 2017 Wiley Periodicals, Inc.
Source: The Prostate - February 23, 2017 Category: Urology & Nephrology Authors: Hai Huang, Tao Du, Yiming Zhang, Yiming Lai, Kaiwen Li, Xinxing Fan, Dingjun Zhu, Tianxin Lin, Kewei Xu, Jian Huang, Leyuan Liu, Zhenghui Guo Tags: Original Article Source Type: research

Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells
Previous studies have shown that increased parathyroid hormone (PTH) attributable to secondary hyperparathyroidism in chronic kidney disease accelerates the arteriosclerotic fibrosis and calcification. Although the underlying mechanisms remain largely unknown, endothelial cells (ECs) have recently been demonstrated to participate in calcification in part by providing chondrogenic cells via the endothelial-to-mesenchymal transition (EndMT). Therefore, this study aimed to investigate whether elevated PTH could induce endothelial-to-chondrogenic transition in aortic ECs and to determine the possible underlying signaling pathw...
Source: AJP: Renal Physiology - February 28, 2017 Category: Urology & Nephrology Authors: Wu, M., Zhang, J.-D., Tang, R.-N., Crowley, S. D., Liu, H., Lv, L.-L., Ma, K.-L., Liu, B.-C. Tags: RESEARCH ARTICLE Source Type: research

NLRP3 inflammasome activation contributes to aldosterone-induced podocyte injury
Aldosterone (Aldo) has been shown as an important contributor of podocyte injury. However, the underlying molecular mechanisms are still elusive. Recently, the pathogenic role of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in mediating renal tubular damage was identified while its role in podocyte injury still needs evidence. Thus the present study was undertaken to investigate the role of NLRP3 inflammasome in Aldo-induced podocyte damage. In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1, and IL-18 expressions in dose- and time-dependent manners, indicating an activation of NL...
Source: AJP: Renal Physiology - April 1, 2017 Category: Urology & Nephrology Authors: Bai, M., Chen, Y., Zhao, M., Zhang, Y., He, J. C.-J., Huang, S., Jia, Z., Zhang, A. Tags: RESEARCH ARTICLE Source Type: research

Re: Mg(II)-Catechin Nanoparticles Delivering siRNA Targeting EIF5A2 Inhibit Bladder Cancer Cell Growth In Vitro and In Vivo
Z. Chen, T. Yu, B. Zhou, J. Wei, Y. Fang, J. Lu, L. Guo, W. Chen, Z. P. Liu and J. Luo
Source: The Journal of Urology - May 10, 2017 Category: Urology & Nephrology Authors: Anthony Atala Tags: Urological Survey Source Type: research

Store operated calcium entry suppressed tgf β1-smad3 signaling pathway in glomerular mesangial cells.
STORE OPERATED CALCIUM ENTRY SUPPRESSED TGFβ1-SMAD3 SIGNALING PATHWAY IN GLOMERULAR MESANGIAL CELLS. Am J Physiol Renal Physiol. 2017 Jun 21;:ajprenal.00483.2016 Authors: Chaudhari S, Li W, Wang Y, Jiang H, Ma Y, Davis ME, Zuckerman JE, Ma R Abstract Our previous study demonstrated that the abundance of extracellular matrix proteins was suppressed by store-operated Ca2+ entry in mesangial cells (MCs). The present study was conducted to investigate the underlying mechanism focused on the transforming growth factor beta 1 (TGFβ1) - Smad3 pathway, a critical pathway for ECM expansion in diabetic kidney...
Source: Am J Physiol Renal P... - June 21, 2017 Category: Urology & Nephrology Authors: Chaudhari S, Li W, Wang Y, Jiang H, Ma Y, Davis ME, Zuckerman JE, Ma R Tags: Am J Physiol Renal Physiol Source Type: research

TNF- α Deficiency Prevents Renal Inflammation and Oxidative Stress in Obese Mice
Conclusion: These findings suggest that TNF- α plays an important role in the HFD induced kidney damage, and targeting TNF-α and/or its receptors could be a promising therapeutic regimen for progressive nephropathy.Kidney Blood Press Res 2017;42:416 –427
Source: Kidney and Blood Pressure Research - July 6, 2017 Category: Urology & Nephrology Source Type: research