STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark of ADPKD is increased epithelial proliferation, which has been proposed to be due to atypical signaling including abnormal JAK-STAT activity. However, the relative contribution of JAK-STAT family members in promoting proliferation in ADPKD is unknown. Here, we present siRNA JAK-STAT –focused screens discovering a previously unknown proliferative role for multiple JAK-STAT components (including STAT1, STAT2, STAT4, STAT5a, and STAT5b).

Source: Kidney International - January 15, 2017 Category: Urology & Nephrology Authors: Maria Fragiadaki, Morgane Lannoy, Madeleine Themanns, Barbara Maurer, Wouter N. Leonhard, Dorien J.M. Peters, Richard Moriggl, Albert C.M. Ong Tags: Basic Research Source Type: research