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New findings on tolvaptan as autosomal dominant polycystic kidney disease treatment
(Mayo Clinic) A phase 3 trial studying the effects of tolvaptan has found that the drug slowed the rate of decline in kidney function in patients with the most common form of polycystic kidney disease, a condition with no cure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 4, 2017 Category: International Medicine & Public Health Source Type: news

Vicente Torres, M.D., Ph.D., discusses new findings on tolvaptan as autosomal dominant polycystic kidney disease treatment
ROCHESTER, Minn. ? A phase 3 trial studying the effects of tolvaptan has found that the drug slowed the rate of decline in kidney function in patients with the most common form of polycystic kidney disease, a condition with no cure. The results are published today in the New England Journal of Medicine. Autosomal dominant [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - November 4, 2017 Category: Hospital Management Source Type: news

Leukemia Drug Bosutinib Shows Promise for Inherited Kidney Disease Leukemia Drug Bosutinib Shows Promise for Inherited Kidney Disease
The tyrosine kinase inhibitor bosutinib, approved for chronic myeloid leukemia, reduced kidney growth rate in patients with autosomal dominant polycystic kidney disease (ADPKD) in a phase 2 study.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - August 31, 2017 Category: Intensive Care Tags: Nephrology News Source Type: news

Green mamba venom could treat kidney disease
A peptide in green mamba venom can reduce the severity of a genetic disorder called polycystic kidney disease (PKD), researchers from France, Belgium and Germany have found. (Source: the Mail online | Health)
Source: the Mail online | Health - June 20, 2017 Category: Consumer Health News Source Type: news

Biochemical pathways of kidney disease revealed
Researchers have developed an innovative fruit fly-based model of the types of harmful cysts that can form on kidneys. The model has enormous potential for assisting the study of how cells proliferate in polycystic kidney disease and cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 2, 2017 Category: Science Source Type: news

Revealed: The biochemical pathways of kidney disease
(Concordia University) In a study, recently published in PLOS Genetics, Chiara Gamberi and her coauthors developed an innovative fruit fly-based model of the types of harmful cysts that can form on kidneys. The model has enormous potential for assisting the study of how cells proliferate in polycystic kidney disease and cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 2, 2017 Category: Global & Universal Source Type: news

GI Manifestations of Autosomal-Dominant PKD GI Manifestations of Autosomal-Dominant PKD
Gastrointestinal manifestations play a significant role in autosomal-dominant polycystic kidney disease, particularly in older patients. Review the effects on the digestive system in this article.Clinical Gastroenterology and Hepatology (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 24, 2017 Category: Transplant Surgery Tags: Gastroenterology Journal Article Source Type: news

Researchers develop potential treatment for fatal kidney disease
Researchers have developed a potential drug to treat polycystic kidney disease -- an incurable genetic disease that often leads to end-stage kidney failure. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 16, 2017 Category: Science Source Type: news

Mother's anguish
Mandy Littlewood has polycystic kidney disease and needed an organ transplant. Two of her children also have the condition. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 21, 2016 Category: Consumer Health News Source Type: news

Welsh man's kidneys swell up after being diagnosed with polycystic kidney disease
Rob Thomas, 44, from Pembroke Dock, Wales, was diagnosed with polycystic kidney disease - an illness which causes cysts to develop in the organs - six years ago (Source: the Mail online | Health)
Source: the Mail online | Health - October 4, 2016 Category: Consumer Health News Source Type: news

Polycystic Kidney Disease Tied to Increased Risk for Kidney, Gastric Cancers (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and Andr é Sofair, MD, MPH Adults with polycystic kidneys may have increased risk for multiple cancers, regardless of kidney function, suggests a Lancet Oncology study.Using a Taiwanese health insurance database, researchers … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 21, 2016 Category: Primary Care Source Type: news

Donate a Kidney Now; Get a Voucher for One Later
Howard Broadman, a lawyer and retired judge from California, knows his grandson, Quinn, will probably one day require a kidney transplant. By the time Quinn needs his help, however, Broadman said he may be dead or too old to donate a healthy organ. "I approached UCLA and asked, 'Why don't I give a kidney to someone who needs it now, then get a voucher for my grandson to use when he needs a transplant in the future?' And that's just what we did," Broadman said in a statement. How the program works Broadman worked with Dr. Jeffrey Veale, a transplant surgeon who helped initiate the program at the Ronald Reagan ...
Source: Healthy Living - The Huffington Post - July 19, 2016 Category: Consumer Health News Source Type: news

Virtual tissue technology reveals new drug target in polycystic kidney disease
Using virtual tissue technology, researchers have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States. The study reveals that errors in how cells stick together give rise to two forms of kidney cysts. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 27, 2016 Category: Science Source Type: news

IU study: Virtual tissue technology reveals new drug target in polycystic kidney disease
(Indiana University) Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States. The study, which reveals that errors in how cells stick together give rise to two forms of kidney cysts, appears in the journal Molecular Biology of the Cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 27, 2016 Category: Global & Universal Source Type: news

Discovery's Edge: Tackling Polycystic Kidney Disease
The term “teamwork” is widely used when talking about scientific research, but when it comes to the Mayo Clinic version, it means cross-disciplinary teams with complementary members. Some teams form to pursue special problems for limited periods, while others form alliances that last for years, with prolific results. The latter is the case with a [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 2, 2016 Category: Databases & Libraries Source Type: news

Signed, sealed, undelivered: Mechanisms underlying polycystic kidney disease
(Medical University of South Carolina) Zebrafish help investigators at the Medical University of South Carolina shed light on the mechanisms underlying cilia dysfunction in polycystic kidney disease and other ciliopathies (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 17, 2016 Category: Global & Universal Source Type: news

Shaping lumens by force
(National University of Singapore) Scientists from Singapore and France have revealed the underlying mechanism for the formation and growth of a fundamental type of tissue -- epithelial tubes. Defects in the architecture of epithelial tubes lead to diseases such as cholestasis, atherosclerosis and polycystic kidney disease. The study suggests that the shape and size of some types of epithelial tubes are governed by the mechanical forces that arise from the interaction of cells with the supportive extracellular matrix that surrounds them (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 23, 2016 Category: Biology Source Type: news

A diet dividend: Reducing food intake in mice diminishes the growth of their polycystic kidneys
What if polycystic kidney disease (PKD) could be combatted with a strategy as simple as dieting? Such a finding would surely be welcome news to the 12 million people worldwide with the genetic disease. Now researchers say that reducing food intake in mice diminishes the growth of their polycystic kidneys. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 29, 2016 Category: Science Source Type: news

A diet dividend
(University of California - Santa Barbara) Members of the Thomas Weimbs Lab demonstrate that reducing food intake in mice diminishes the growth of their polycystic kidneys (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 28, 2016 Category: Biology Source Type: news

SMC issues positive advice for first ever treatment for ADPKD
JINARC® (tolvaptan) is accepted for use in Scotland for the treatment of autosomal dominant polycystic kidney disease (ADPKD) (Source: Pharmacy Europe)
Source: Pharmacy Europe - January 11, 2016 Category: Drugs & Pharmacology Authors: Annabel De Coster Tags: *** Editor's Pick Practical therapeutics Legislation & regulation Nephrology Patient care adpkd jinarc Latest News smc tolvaptan Source Type: news

When Ayden met Aubrey: Kidney transplant creates a powerful bond between toddlers
Photos by Katherine C. Cohen Theirs is a friendship nurtured by coloring books, built on board games and mad dashes down corridors — but also silently strengthened by nature of a mutual struggle. Three-year-old Ayden Mosher of New York and 2-year-old Aubrey Ferrell of Tennessee met this fall in a lab at Boston Children’s Hospital. It was friendship at first sight. “They were just drawn to each other, and they have been inseparable ever since,” says Aubrey’s mom Janna Ferrell. Aubrey’s story Aubrey was diagnosed with congenital nephrotic syndrome at 4 months old. By 18 months, both kidne...
Source: Thrive, Children's Hospital Boston - January 7, 2016 Category: Pediatrics Authors: Emily Williams Tags: Diseases & Conditions Our Patients’ Stories kidney kidney transplant Pediatric Transplant Center (PTC) Source Type: news

In their own words: Six families share the impact of organ donation
This is the season for gratitude and giving, a time to celebrate friends, family, the end of one year and the beginning of a new one. But for a select group, it also is a time to celebrate one of the greatest gifts — the gift of life through organ donation. Mickey was born with a unique combination of congenital heart defects and spent most of his early life at Boston Children’s. He was one day shy of 6 months old when he received his heart transplant, and his family is grateful for every day since. “Mickey has shown us what courage and resiliency look like, and his transplant has taught us the true mean...
Source: Thrive, Children's Hospital Boston - January 5, 2016 Category: Pediatrics Authors: Michelle Higginson Tags: Diseases & Conditions Our Patients’ Stories double lung transplant heart transplant hepatoblastoma kidney transplant Liver transplant multivisceral transplant Pediatric Transplant Center (PTC) Source Type: news

Linking Cancer and Polycystic Kidney Disease
Polycystic kidney disease (PKD) is one of the most common inherited diseases—a parent with PKD has a 50 percent chance of passing the disease on to their child.12/15/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - December 15, 2015 Category: Urology & Nephrology Source Type: news

At ASCB 2015: CRISPR/Cas9 + HPSC = human PKD lab model
(American Society for Cell Biology) By linking up CRISPR/Cas9 with another cutting edge technology, human pluripotent stem cells (hPSCs), Benjamin Freedman, now at the University of Washington, and his colleagues in Joseph Bonventre's lab at Harvard Medical School, have used CRISPR/Cas9 to guide hPSCs into becoming a human cell-based lab model system for polycystic kidney disease (PKD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2015 Category: Global & Universal Source Type: news

How A Tinder Date Led To A Lifesaving Kidney Donation
ABC Breaking News | Latest News Videos While scrolling through Tinder over the summer, this guy swiped right -- very, very right. Rich O’Dea, a man from Tampa, Florida, and his match from the dating app, Jennifer Thomas, unexpectedly helped save a life, when the pair found out Thomas was a donor match for O’Dea’s best friend’s wife who needed a kidney transplant, ABC News reported. While out on their first date after being paired on the app, O’Dea shared with Thomas that his friend's wife, Erika Bragan, had been on the kidney donor list for nearly three years, and just days after the date, Tho...
Source: Healthy Living - The Huffington Post - November 13, 2015 Category: Consumer Health News Source Type: news

Study: Food Restriction Prevents and Reverses Polycystic Kidney Disease in Mice
https://www.youtube.com/watch?v=PR6klhuVeyw ROCHESTER, Minn. — Researchers at Mayo Clinic have found that a mild to moderate reduction in calories effectively prevents and reverses polycystic kidney disease (PKD) in mice. The results appear online today in the Journal of the American Society of Nephrology. “Currently, there is no FDA-approved treatment, and the only thing that can be done [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 4, 2015 Category: Databases & Libraries Source Type: news

NICE approves new drug for chronic kidney disease
For the first time, a treatment will be available on the NHS in England and Wales that can delay the development of autosomal dominant polycystic kidney disease (ADPKD). (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - October 28, 2015 Category: Nursing Source Type: news

Former GSK execs get $3.2M for research on a possible diabetes drug
A small Research Triangle Park company seeking to find next-generation drugs, received two federal grants totaling $3.2 million, an amount that will nearly triple the total the company has raised to date. NovaTarg – owned and led by former GlaxoSmithKline executives – will use the money to continue research on potential drug candidates for polycystic kidney disease and type 2 diabetes during this coming year. Diabetes is a potentially huge market, with some analysts estimating that even just… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 28, 2015 Category: Biotechnology Authors: Jason deBruyn Source Type: news

Medical News Today: New drug delivery system may open up treatments for polycystic kidney disease
A new method that allows antibodies to penetrate cyst walls may open the door for already approved drugs to target the growth factors that drive polycystic kidney disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 26, 2015 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Delivering drugs to the right place
For the 12 million people worldwide who suffer from polycystic kidney disease (PKD), an inherited disorder with no known cure, a new treatment option may be on the horizon. A targeted drug delivery method has been developed that could potentially slow the progression of polycystic kidney disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 25, 2015 Category: Science Source Type: news

New treatment for polycystic kidney disease
(University of Manchester) A new technique for treating polycystic kidney disease has been identified by researchers at The University of Manchester and UCL. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 3, 2015 Category: Global & Universal Source Type: news

New treatment for polycystic kidney disease
A new technique for treating polycystic kidney disease has been identified by researchers. Polycystic kidney disease (PKD) is a genetic disorder where fluid filled cysts grow in kidneys and destroy normal renal tissue. It is the world's most common inherited kidney disease, affecting between 1 in 400 and 1 in 1000 people worldwide -- around 12.5 million individuals. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 2, 2015 Category: Science Source Type: news

Tolvaptan (Jinarc) Cleared in Europe for Rare Kidney DiseaseTolvaptan (Jinarc) Cleared in Europe for Rare Kidney Disease
The vasopressin-2 receptor antagonist is the first drug to be licensed in Europe for the treatment of the underlying pathophysiology of autosomal dominant polycystic kidney disease. International Approvals (Source: Medscape Nurses Headlines)
Source: Medscape Nurses Headlines - May 27, 2015 Category: Nursing Tags: Nephrology News Alert Source Type: news

Indian man's kidneys grew to size of a baby due to genetic disease
The man, who was treated at a hospital in Delhi, was suffering from autosomal dominant polycystic kidney disease, a genetic condition that caused his organs to grow to 20 times their normal size. (Source: the Mail online | Health)
Source: the Mail online | Health - April 22, 2015 Category: Consumer Health News Source Type: news

Jinarc (tolvaptan) for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Jinarc (tolvaptan) is indicated for the treatment of autosomal dominant polycystic kidney disease (ADPKD). (Source: Drug Development Technology)
Source: Drug Development Technology - March 19, 2015 Category: Pharmaceuticals Source Type: news

CHMP Backs Tolvaptan (Jinarc) for Rare Kidney DiseaseCHMP Backs Tolvaptan (Jinarc) for Rare Kidney Disease
Tolvaptan, a vasopressin-2-receptor antagonist that slows cyst formation, would be the first drug specifically approved in the European Union for autosomal dominant polycystic kidney disease. International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 27, 2015 Category: Consumer Health News Tags: Nephrology News Alert Source Type: news

Expert panel recommends new approaches to management of ADPKD
A report has been published by the European ADPKD Forum (EAF), an international, multidisciplinary panel of experts from the fields of nephrology, hepatology and genetics, as well as patient group representatives, dedicated to improving the health and quality of life of people with autosomal dominant polycystic kidney disease (ADPKD) – a chronic, progressive, inherited disease in which fluid-filled cysts grow in the kidneys and liver. (Source: Pharmacy Europe)
Source: Pharmacy Europe - January 30, 2015 Category: Drugs & Pharmacology Authors: Annabel De Coster Tags: *** Editor's Pick Association News Practical therapeutics Nephrology Patient care Autosomal dominant polycystic kidney disease cysts EAF economic impact hypertension Latest News Source Type: news

No Help From Dual RAAS Blockade in PKD (CME/CE)
(MedPage Today) -- No benefit to combining ACE inhibitor with ARB in polycystic kidney disease. (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - November 17, 2014 Category: Urology & Nephrology Source Type: news

Dual RAAS Blockade No Better Than ACE Inhibitor to Slow PKDDual RAAS Blockade No Better Than ACE Inhibitor to Slow PKD
In early or moderate autosomal dominant polycystic kidney disease, dual RAAS blockade did not slow the long-term decline in kidney function when compared with an ACE inhibitor alone. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 16, 2014 Category: Consumer Health News Tags: Nephrology News Source Type: news

Two drugs are no more effective than 1 to treat common kidney disease
(NIH/National Institute of Diabetes and Digestive and Kidney Diseases) Using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease (ADPKD), according to two studies funded by the National Institutes of Health. One of the studies also showed that rigorous blood pressure treatment slowed growth of kidney cysts, a marker of ADPKD, but had little effect on kidney function compared to standard blood pressure treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2014 Category: Global & Universal Source Type: news

Kadmon begins Phase IIa Portion of KD020 study
Kadmon has started the Phase IIa portion of a Phase Ib/IIa study of KD020 in autosomal dominant polycystic kidney disease (ADPKD), following unanimous recommendation of the study's data safety committee. (Source: Drug Development Technology)
Source: Drug Development Technology - June 22, 2014 Category: Pharmaceuticals Source Type: news

European ADPKD forum launches
The European ADPKD Forum (EAF) has been created, which is a new multidisciplinary group of leading medical and patient group experts dedicated to improving the health and quality of life of people with autosomal dominant polycystic kidney disease (ADPKD). (Source: Pharmacy Europe)
Source: Pharmacy Europe - June 2, 2014 Category: Drugs & Pharmacology Authors: AMcculloch Tags: Nephrology Autosomal dominant polycystic kidney disease genetic kidney disease Latest News multidisciplinary expert group Source Type: news

Patients with a certain form of kidney disease may have reduced risk of cancer
After adjusting for demographic differences between kidney transplant recipients with polycystic kidney disease (PKD) and other kidney transplant recipients, PKD patients were 16 percent less likely to develop cancer than others who received a kidney transplant. Polycystic kidney disease (PKD) is a kidney disorder passed down through families in which many cysts form in the kidneys, causing them to become enlarged. It's thought to have cancer-like features, but cancer risk has never been compared between PKD patients and others with kidney disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 22, 2014 Category: Science Source Type: news

Type of Kidney Disease May Dictate Cancer Risk
Study of transplant recipients finds prospects best with polycystic kidney disease Source: HealthDay Related MedlinePlus Pages: Cancer, Kidney Cysts, Kidney Transplantation (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - May 22, 2014 Category: Consumer Health News Source Type: news

Type of Kidney Disease May Dictate Cancer Risk
Study of transplant recipients finds prospects best with polycystic kidney disease (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 22, 2014 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Nephrology, Oncology, Organ Transplants, News, Source Type: news

Statins given early decrease progression of kidney disease
(University of Colorado Denver) Results from a study by University of Colorado School of Medicine researchers show that pravastatin, a medicine widely used for treatment of high cholesterol, also slows down the growth of kidney cysts in children and young adults with autosomal dominant polycystic kidney disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 8, 2014 Category: Biology Source Type: news

Otsuka's kidney drug Samsca receives approval in Japan
Otsuka Pharmaceutical has received regulatory approval from Japanese authorities for Samsca for a pharmacological treatment of autosomal dominant polycystic kidney disease (ADPKD). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - March 26, 2014 Category: Pharmaceuticals Source Type: news

Polycystic Kidney Disease (PKD)
Title: Polycystic Kidney Disease (PKD)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 3/19/2014 12:00:00 AM (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - March 19, 2014 Category: Gastroenterology Source Type: news

Could grapefruit be good for your kidneys?
Scientists at Royal Holloway, University of London, have discovered that a natural product found in grapefruit can prevent kidney cysts from forming.Naringenin, which is also present in other citrus fruits, has been found to successfully block the formation of kidney cysts, an effect that occurs in polycystic kidney disease, by regulating the PKD2 protein responsible for the condition. With few treatments currently available, symptoms include high blood pressure and loss of kidney function, and lead to the need for dialysis. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 14, 2014 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Could grapefruit be good for your kidneys?
A natural product found in grapefruit can prevent kidney cysts from forming, new research indicates. Naringenin, which is also present in other citrus fruits, has been found to successfully block the formation of kidney cysts, an effect that occurs in polycystic kidney disease, by regulating the PKD2 protein responsible for the condition. With few treatments currently available, symptoms include high blood pressure and loss of kidney function, and lead to the need for dialysis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 12, 2014 Category: Science Source Type: news