Reproducing the pathophysiology of polycystic kidney disease from human iPS cells
(Kumamoto University) A joint research project has successfully reproduced the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) from human iPS cells in vitro. Although cysts derived from renal tubules have been previously documented, this is the first derivation of cysts from collecting ducts, which is more closely related to the pathogenesis of the disease. This research is expected to lead to a better understanding of disease states and the development of new treatment methods. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 21, 2020 Category: Biology Source Type: news

Polycystic Kidney Disease Affect the Kidneys
How Does Polycystic Kidney Disease Affect the Kidneys? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 16, 2020 Category: General Medicine Source Type: news

Qualification of Biomarker Total Kidney Volume in Studies for Treatment of Autosomal Dominant Polycystic Kidney Disease Draft Guidance for Industry
Drug Development Tools (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 15, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Surgeons remove 'the largest ever KIDNEY' weighing 16lbs from a 56-year-old man in India
Medical staff at the Sir Ganga Ram Hospital in New Delhi, India, removed the giant kidney from a man who was preparing to have a transplant. He has a condition called polycystic kidney disease. (Source: the Mail online | Health)
Source: the Mail online | Health - November 26, 2019 Category: Consumer Health News Source Type: news

Children's National receives $6 million for global polycystic kidney disease initiative
(Children's National Hospital) Lisa M. Guay-Woodford, MD, McGehee Joyce Professor of Pediatrics at Children's National Hospital, has received a $5.7 million dollar gift to support clinical and research activities. Polycystic kidney disease is a genetic disorder characterized by clusters of fluid-filled sacs (cysts) multiplying and interfering with the kidneys' ability to filter waste from the blood. The kidneys' smooth surface transforms to a bumpy texture as the essential organs grow oversized and riddled with cysts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 13, 2019 Category: International Medicine & Public Health Source Type: news

Kidney Swaps Are Revolutionizing a Broken Organ-Donation System in the U.S.
2017 ended as a banner year for my family, but things didn’t look great at the start. A death sentence met us in a boxing ring, and we had to school ourselves on fighting to live. I never thought much about the 37 million American adults who suffer from kidney disease until my husband Neil became one of them. Celebrating our first year of marriage in 2001, we learned by accident through an unrelated medical exam that my husband has polycystic kidney disease, an illness which causes the kidneys to fill with cysts over time, rendering the organs unable to function properly. There is no cure. There was nothing to do but...
Source: TIME: Health - November 5, 2019 Category: Consumer Health News Authors: Lisa Emmott Tags: Uncategorized health Healthcare medicine public health Source Type: news

A promising treatment for an incurable, deadly kidney disease
A potential treatment for polycystic kidney disease - a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure - has shown promising results in animal testing. A study describing the drug's development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in afflicted mice following treatment. (Source: World Pharma News)
Source: World Pharma News - September 12, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Autosomal Dominant Polycystic Kidney Disease: Studies in Comorbidity
Studies on comorbidities seen with CKD reviewed here examine controlled vs uncontrolled gout, psychiatric diagnoses, and screening for intracranial aneurysm. (Source: ConsultantLive)
Source: ConsultantLive - September 6, 2019 Category: Internal Medicine Tags: Kidney Disease Source Type: news

Should ADPKD Patients Be Screened for Hidden Aneurysms? Should ADPKD Patients Be Screened for Hidden Aneurysms?
Screening patients with polycystic kidney disease who are at risk for brain aneurysms pays off, but current screening recommendations shouldn't be altered, say authors.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - August 1, 2019 Category: Neurology Tags: Nephrology News Source Type: news

Brain Aneurysm Risk Examined in Polycystic Kidney Disease
THURSDAY, Aug. 1, 2019 -- Intracranial aneurysms are detected in 9 percent of patients with autosomal dominant polycystic kidney disease (ADPKD) undergoing magnetic resonance angiography (MRA) screening, according to a study published online July 30... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 1, 2019 Category: Pharmaceuticals Source Type: news

Autosomal-dominant Polycystic Kidney Disease: 3 Studies in Brief
Three new studies on ADPKD treatment project long-term impact of tolvaptan; reveal potential in an existing drug class; and, report success in slowing comorbid hepatic disease.   (Source: ConsultantLive)
Source: ConsultantLive - July 8, 2019 Category: Internal Medicine Authors: Andrew D. Bowser Tags: Kidney Disease Source Type: news

KC charity will invest $5M to fund research into a cure for PKD
The PKD Foundation will invest nearly $5 million on research over the next two years to fund treatment studies and research polycystic kidney disease. "For the past 36 years, our goal has been to support PKD patients from care to cure. With the support of generous donations, we have the ability to stand beside PKD patients until there is a cure, supporting research for new treatments and to support researchers," PKD Foundation CEO Andy Betts sai d in a news release. The foundation announced that… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - June 25, 2019 Category: Biotechnology Authors: Lily Lieberman Source Type: news

KC charity will invest $5M to fund research into a cure for PKD
The PKD Foundation will invest nearly $5 million on research over the next two years to fund treatment studies and research polycystic kidney disease. "For the past 36 years, our goal has been to support PKD patients from care to cure. With the support of generous donations, we have the ability to stand beside PKD patients until there is a cure, supporting research for new treatments and to support researchers," PKD Foundation CEO Andy Betts sai d in a news release. The foundation announced that… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 25, 2019 Category: American Health Authors: Lily Lieberman Source Type: news

Polycystic Kidney Disease (PKD)
Title: Polycystic Kidney Disease (PKD)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/17/2019 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - June 17, 2019 Category: Nutrition Source Type: news

Too close not to encyst: Polycystic kidney disease and interorganellar contact sites
Mitofusin 2 (MFN2) tethers mitochondria to the endoplasmic reticulum (ER). In the 7 May 2019 issue of Science Signaling, Kuo et al. report that polycystin 2 (PC2), encoded by a gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), contributes to cystogenesis by affecting MFN2, thus extending the role of mitochondria-ER contact sites to a common genetic disorder. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 28, 2019 Category: Science Authors: Lorenzi, I., Scorrano, L. Tags: STKE Focus Source Type: news

Polycystic Kidney Disease: Studies on Obesity, Pain, Screening
Find summaries here of 3 recent studies conducted to shed light on difficult issues in the management of autosomal dominant polycystic kidney disease: (Source: ConsultantLive)
Source: ConsultantLive - May 10, 2019 Category: Internal Medicine Authors: Andrew Bowser Tags: Kidney Disease Source Type: news

New strategy for untreatable kidney disease: targeting cell energy
By targeting a protein called Polycystin 2, Yale researchers have identified a promising approach for treating autosomal dominant polycystic kidney disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - May 7, 2019 Category: Universities & Medical Training Source Type: news

Polycystic Kidney Disease: How Much Do You Know?
Autosomal dominant polycystic kidney disease us the most common form of polycystic renal disease. Find out what you know about ADPKD with this 7-question quiz on epidemiology, diagnosis, and more.   (Source: ConsultantLive)
Source: ConsultantLive - May 7, 2019 Category: Internal Medicine Authors: Andrew D. Bowser Tags: Kidney Disease Source Type: news

Polycystic Kidney Disease: What & #039;s Your ADPKD IQ?
Autosomal dominant polycystic kidney disease is the most common form of polycystic renal disease. Find out what you know about ADPKD with this 7-question quiz on epidemiology, diagnosis, and more.   (Source: ConsultantLive)
Source: ConsultantLive - May 7, 2019 Category: Internal Medicine Authors: Andrew D. Bowser Tags: Kidney Disease Source Type: news

Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2
Mitochondria and the endoplasmic reticulum (ER) have an intimate functional relationship due to tethering proteins that bring their membranes in close (~30 nm) apposition. One function of this interorganellar junction is to increase the efficiency of Ca2+ transfer into mitochondria, thus stimulating mitochondrial respiration. Here, we showed that the ER cation-permeant channel polycystin 2 (PC2) functions to reduce mitochondria-ER contacts. In cell culture models, PC2 knockdown led to a 50% increase in mitofusin 2 (MFN2) expression, an outer mitochondrial membrane GTPase. Live-cell super-resolution and electron microscopy ...
Source: Signal Transduction Knowledge Environment - May 7, 2019 Category: Science Authors: Kuo, I. Y., Brill, A. L., Lemos, F. O., Jiang, J. Y., Falcone, J. L., Kimmerling, E. P., Cai, Y., Dong, K., Kaplan, D. L., Wallace, D. P., Hofer, A. M., Ehrlich, B. E. Tags: STKE Research Articles Source Type: news

An international prize honors Bradley Yoder for research in polycystic kidney disease
(University of Alabama at Birmingham) Bradley K. Yoder, Ph.D., professor and chair of the Department of Cell, Developmental and Integrative Biology at the University of Alabama at Birmingham, has been awarded with a Lillian Jean Kaplan International Prize for Advancement for his significant research in the polycystic kidney field. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 29, 2019 Category: Biology Source Type: news

Infographic: Polycystic kidney disease (PKD)
Learn more about polycystic kidney disease. Other health tip infographics: mayohealthhighlights.startribune.com? (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 6, 2019 Category: Databases & Libraries Source Type: news

Tolvaptan listed for polycystic kidney disease in Australia
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - January 1, 2019 Category: Drugs & Pharmacology Source Type: news

Seeing is believing: Monitoring real time changes during cell division
(Lancaster University) Scientist have cast new light on the behaviour of tiny hair-like structures called cilia found on almost every cell in the body. Cilia play important roles in human development and disease. Akin to tiny antennae, they act as cell timers keeping the brakes on cell division until the right growth cues are received. Malfunction of cilia leads to many human diseases such as polycystic kidney disease and cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 19, 2018 Category: Cancer & Oncology Source Type: news

#MayoClinicRadio podcast: 10/20/18
Listen: Mayo Clinic Radio 10/20/18 On the Mayo Clinic Radio podcast, Katherine Zeratsky, a registered dietitian and nutritionist at Mayo Clinic, discusses juicing, lectins and other diet trends.?Also on the podcast, Dr. Fouad Chebib, a nephrologist at Mayo Clinic, explains polycystic kidney disease.?And Dr. Dawn Davis, a dermatologist at Mayo Clinic, discusses diseases of the [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - October 22, 2018 Category: Databases & Libraries Source Type: news

3-year-old girl gets life-saving birthday gift: a new liver and kidney
Lilah Joiner, from Carthage, Mississippi, was born with autosomal recessive polycystic kidney disease (ARPKD). (Source: ABC News: Health)
Source: ABC News: Health - October 4, 2018 Category: Consumer Health News Tags: GMA Source Type: news

Structure of the human PKD1-PKD2 complex
Mutations in two genes, PKD1 and PKD2, account for most cases of autosomal dominant polycystic kidney disease, one of the most common monogenetic disorders. Here we report the 3.6-angstrom cryo–electron microscopy structure of truncated human PKD1-PKD2 complex assembled in a 1:3 ratio. PKD1 contains a voltage-gated ion channel (VGIC) fold that interacts with PKD2 to form the domain-swapped, yet noncanonical, transient receptor potential (TRP) channel architecture. The S6 helix in PKD1 is broken in the middle, with the extracellular half, S6a, resembling pore helix 1 in a typical TRP channel. Three positively charged,...
Source: ScienceNOW - September 6, 2018 Category: Science Authors: Su, Q., Hu, F., Ge, X., Lei, J., Yu, S., Wang, T., Zhou, Q., Mei, C., Shi, Y. Tags: Biochemistry, Online Only r-articles Source Type: news

Tolvaptan Works Long Term in Autosomal Dominant Polycystic Kidney Disease Tolvaptan Works Long Term in Autosomal Dominant Polycystic Kidney Disease
A new study demonstrates the long-term efficacy of the vasopressin-2 receptor antagonist tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD).Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 20, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Kidney disease treatment with roots in KC wins approval after 36 years
The Food and Drug Administration gave the green light for the first approved treatment for polycystic kidney disease on Tuesday — a treatment based on research that traces its roots to Kansas City. In the 1960s, late nephrologist and University of Kansas Medical Center Researcher Dr. Jared Grantham discovered the kidney’s components during a research fellowship. Later on, he found a signaling molecule called cyclic AMP that affects the cell growth and fluid secretion in kidneys. This discovery… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 25, 2018 Category: Pharmaceuticals Authors: Elise Reuter Source Type: news

Kidney disease treatment with roots in KC wins approval after 36 years
The Food and Drug Administration gave the green light for the first approved treatment for polycystic kidney disease on Tuesday — a treatment based on research that traces its roots to Kansas City. In the 1960s, late nephrologist and University of Kansas Medical Center Researcher Dr. Jared Grantham discovered the kidney’s components during a research fellowship. Later on, he found a signaling molecule called cyclic AMP that affects the cell growth and fluid secretion in kidneys. This discovery… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 25, 2018 Category: Biotechnology Authors: Elise Reuter Source Type: news

FDA Approves Jynarque (tolvaptan) to Slow Kidney Function Decline in Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease
April 24, 2018 -- TOKYO--(BUSINESS WIRE)--Otsuka Pharmaceutical Co., Ltd. (Otsuka) announces that the U.S. Food and Drug Administration (FDA) has approved Jynarque (tolvaptan) as the first drug treatment to slow kidney function decline in adults at... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - April 24, 2018 Category: Drugs & Pharmacology Source Type: news

Regulation of Cyst Growth in Polycystic Kidney Disease
Cilia, tiny hair-like structures on the kidney, and polycystin-1 and 2 genes, work together to promote cyst growth in mice with polycystic kidney disease. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Former Boston City Councilor John Nucci Waits For A New Kidney
BOSTON (CBS) – John Nucci, a former Boston City Councilor, has developed a genetic disorder and desperately needs a kidney. Nucci is battling Polycystic Kidney Disease and is in the final stages of renal failure. He joined Liam Martin and Paula Ebben on WBZ-TV to discuss Kidney Awareness Month and how to become a living a donor. For more information visit: www.mghlivingdonors.org (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 1, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Syndicated Local John Nucci Kidney liam martin Paula Ebben Polycystic Kidney Disease Source Type: news

Trial to study water as treatment for polycystic kidney disease
Researchers in Australia are conducting a trial to determine whether a prescribed amount of water can reduce kidney failure. (Source: Health News - UPI.com)
Source: Health News - UPI.com - January 29, 2018 Category: Consumer Health News Source Type: news

Tolvaptan and Kidney Function Decline in ADPKD Patients Tolvaptan and Kidney Function Decline in ADPKD Patients
Dr Bansal reviews several studies on the effects of tolvaptan in patients with autosomal dominant polycystic kidney disease. What do the recent trials tell us?Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 7, 2017 Category: Consumer Health News Tags: Nephrology Viewpoint Source Type: news

NJ boy gets transplant after living without kidneys
Ismael Rodriguez-Reyes, 7, was born with polycystic kidney disease, which caused the kidneys to overgrow and form cysts. After finally getting new organs he hopes to return home to New Jersey. (Source: the Mail online | Health)
Source: the Mail online | Health - December 6, 2017 Category: Consumer Health News Source Type: news

Boy, 7, gets transplant after living without kidneys
Ismael Rodriguez-Reyes, 7, was born with polycystic kidney disease, which caused the kidneys to overgrow and form cysts. After finally getting new organs he hopes to return home to New Jersey. (Source: the Mail online | Health)
Source: the Mail online | Health - December 5, 2017 Category: Consumer Health News Source Type: news

New findings on tolvaptan as autosomal dominant polycystic kidney disease treatment
(Mayo Clinic) A phase 3 trial studying the effects of tolvaptan has found that the drug slowed the rate of decline in kidney function in patients with the most common form of polycystic kidney disease, a condition with no cure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 4, 2017 Category: International Medicine & Public Health Source Type: news

Vicente Torres, M.D., Ph.D., discusses new findings on tolvaptan as autosomal dominant polycystic kidney disease treatment
ROCHESTER, Minn. ? A phase 3 trial studying the effects of tolvaptan has found that the drug slowed the rate of decline in kidney function in patients with the most common form of polycystic kidney disease, a condition with no cure. The results are published today in the New England Journal of Medicine. Autosomal dominant [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - November 4, 2017 Category: Hospital Management Source Type: news

Leukemia Drug Bosutinib Shows Promise for Inherited Kidney Disease Leukemia Drug Bosutinib Shows Promise for Inherited Kidney Disease
The tyrosine kinase inhibitor bosutinib, approved for chronic myeloid leukemia, reduced kidney growth rate in patients with autosomal dominant polycystic kidney disease (ADPKD) in a phase 2 study.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - August 31, 2017 Category: Intensive Care Tags: Nephrology News Source Type: news

Green mamba venom could treat kidney disease
A peptide in green mamba venom can reduce the severity of a genetic disorder called polycystic kidney disease (PKD), researchers from France, Belgium and Germany have found. (Source: the Mail online | Health)
Source: the Mail online | Health - June 20, 2017 Category: Consumer Health News Source Type: news

Biochemical pathways of kidney disease revealed
Researchers have developed an innovative fruit fly-based model of the types of harmful cysts that can form on kidneys. The model has enormous potential for assisting the study of how cells proliferate in polycystic kidney disease and cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 2, 2017 Category: Science Source Type: news

Revealed: The biochemical pathways of kidney disease
(Concordia University) In a study, recently published in PLOS Genetics, Chiara Gamberi and her coauthors developed an innovative fruit fly-based model of the types of harmful cysts that can form on kidneys. The model has enormous potential for assisting the study of how cells proliferate in polycystic kidney disease and cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 2, 2017 Category: Global & Universal Source Type: news

GI Manifestations of Autosomal-Dominant PKD GI Manifestations of Autosomal-Dominant PKD
Gastrointestinal manifestations play a significant role in autosomal-dominant polycystic kidney disease, particularly in older patients. Review the effects on the digestive system in this article.Clinical Gastroenterology and Hepatology (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 24, 2017 Category: Transplant Surgery Tags: Gastroenterology Journal Article Source Type: news

Researchers develop potential treatment for fatal kidney disease
Researchers have developed a potential drug to treat polycystic kidney disease -- an incurable genetic disease that often leads to end-stage kidney failure. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 16, 2017 Category: Science Source Type: news

Mother's anguish
Mandy Littlewood has polycystic kidney disease and needed an organ transplant. Two of her children also have the condition. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 21, 2016 Category: Consumer Health News Source Type: news

Welsh man's kidneys swell up after being diagnosed with polycystic kidney disease
Rob Thomas, 44, from Pembroke Dock, Wales, was diagnosed with polycystic kidney disease - an illness which causes cysts to develop in the organs - six years ago (Source: the Mail online | Health)
Source: the Mail online | Health - October 4, 2016 Category: Consumer Health News Source Type: news

Polycystic Kidney Disease Tied to Increased Risk for Kidney, Gastric Cancers (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and Andr é Sofair, MD, MPH Adults with polycystic kidneys may have increased risk for multiple cancers, regardless of kidney function, suggests a Lancet Oncology study.Using a Taiwanese health insurance database, researchers … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 22, 2016 Category: Primary Care Source Type: news

Donate a Kidney Now; Get a Voucher for One Later
Howard Broadman, a lawyer and retired judge from California, knows his grandson, Quinn, will probably one day require a kidney transplant. By the time Quinn needs his help, however, Broadman said he may be dead or too old to donate a healthy organ. "I approached UCLA and asked, 'Why don't I give a kidney to someone who needs it now, then get a voucher for my grandson to use when he needs a transplant in the future?' And that's just what we did," Broadman said in a statement. How the program works Broadman worked with Dr. Jeffrey Veale, a transplant surgeon who helped initiate the program at the Ronald Reagan ...
Source: Healthy Living - The Huffington Post - July 19, 2016 Category: Consumer Health News Source Type: news

Virtual tissue technology reveals new drug target in polycystic kidney disease
Using virtual tissue technology, researchers have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States. The study reveals that errors in how cells stick together give rise to two forms of kidney cysts. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 27, 2016 Category: Science Source Type: news