NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma

Conclusions:
Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that NOTCH1 could regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines. These might provide a basis for the designing new therapeutic strategies for CCRCC.

Source: Urologic Oncology: Seminars and Original Investigations - October 13, 2011 Category: Urology & Nephrology Authors: Shangwen Liu, Xin Ma, Qing Ai, Qingbo Huang, Taoping Shi, Mingyang Zhu, Baojun Wang, Xu Zhang Tags: Clinical - Kidney Source Type: research