A ROS/STAT3/HIF‐1α signaling cascade mediates EGF‐induced TWIST1 expression and prostate cancer cell invasion

CONCLUSIONSWe demonstrate a mechanism by which EGF promotes prostate cancer cell progression through a ROS/STAT3/HIF‐1α/TWIST1/N‐cadherin signaling cascade, providing novel biomarkers and promising therapeutic targets for prostate cancer cell progression. Prostate © 2014 Wiley Periodicals, Inc.

Source: The Prostate - January 16, 2014 Category: Urology & Nephrology Authors: Kyung Hwa Cho, Moon Jung Choi, Kang Jin Jeong, Jeong Jin Kim, Min Ha Hwang, Shang Cheul Shin, Chang Gyo Park, Hoi Young Lee Tags: Original Article Source Type: research