Indoxyl Sulfate Induces IL-6 Expression in Vascular Endothelial and Smooth Muscle Cells through OAT3-Mediated Uptake and Activation of AhR/NF- & #954;B Pathway
Conclusion: IS induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3/AhR/NF-#954;B pathway.Nephron Exp Nephrol 2014;128:1-8 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 9, 2017 Category: Urology & Nephrology Source Type: research
Increased Macrophage Activation Inhibited by Tacrolimus in the Kidney of Diabetic Rats
Conclusion: The data from the current study demonstrated that tacrolimus could ameliorate early renal injury through a mechanism to suppress macrophage activation.Nephron Exp Nephrol 2014;128:46-56 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Macrophage Depletion Ameliorates Glycerol-Induced Acute Kidney Injury in Mice
Conclusion: These results support the hypothesis that depletion of macrophages prevents renal dysfunction by abrogating apoptosis and attenuating inflammation during AKI.Nephron Exp Nephrol 2014;128:21-29 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Multiple Mechanisms in Renal Artery Stenosis-Induced Renal Interstitial Fibrosis
Conclusion: Our study provides a novel insight into the mechanisms linking peritubular capillary loss and pericyte changes in RAS-induced renal fibrosis. Our findings also suggest that inflammatory macrophages and Wnt/ β-catenin signaling participate in these pathological processes. Therefore, multi-target therapeutic strategies may significantly contribute to the prevention of renal interstitial fibrosis and the preservation of renal function in patients with RAS.Nephron Exp Nephrol 2014;128:57-66 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Protective Effects of Relaxin against Cisplatin-Induced Nephrotoxicity in Rats
Conclusions: The results suggested that RLX provided protection against CDDP-induced AKI and subsequent fibrosis by reducing apoptosis and inflammation.Nephron Exp Nephrol 2014;128:9-20 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Wnt5a Is Necessary for Normal Kidney Development in Zebrafish and Mice
Conclusions: Our data demonstrated the important role ofWnt5a in kidney development. Disrupted Wnt5a resulted in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.Nephron Exp Nephrol 2014;128:80-88 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers
Conclusions: Our data suggest that levels of renoprotective AMPK activity and canonical autophagy are insufficient to maintain cellular homeostasis, contributing to the progression of ischemia-reperfusion injury. We further demonstrate that induction of AMPK activity can provide beneficial cellular effects in containing injury in ischemia-reperfusion.Nephron Exp Nephrol 2014;128:98-110 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Polyuria in Hantavirus Infection Reflects Disease Severity and Is Associated with Prolonged Hospital Stay: A Systematic Analysis of 335 Patients from Southern Germany
Background/Aims: Puumala virus (PUUV) infection leads to nephropathia epidemica (NE), especially in endemic areas in Central Europe. The clinical course of NE is characterized by acute kidney injury (AKI) with thrombocytopenia followed by polyuria to a different degree. The prevalence of polyuria and its associated risk factors have not been reported in a large cohort of NE patients.Methods: Clinical and laboratory data during the acute phase of the disease were obtained from the medical reports and files of 335 patients who received in-hospital treatment during acute hantavirus infection. Comprehensive statistical models ...
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells
Conclusion: AngII, glucose, and osmotic stress (mannitol) activate COX-2; NF-#954;B may be an ideal site for COX-2 blockade, and COX-2 activation by osmotic stress requires AT1R, but activation by glucose is more robust and mechanistically complex.Nephron Exp Nephrol 2014;128:89-97 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats
Conclusion: Results suggest that H2 gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cell apoptosis and oxidative stress.Nephron Exp Nephrol 2014;128:116-122 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Contents Vol. 128, 2014
Nephron Exp Nephrol 2014;128:I-VI (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 25, 2017 Category: Urology & Nephrology Source Type: research
Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats
Conclusion: Results suggest that H2 gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cell apoptosis and oxidative stress. © 2015 S. Karger AG, Basel.PMID:25592271 | DOI:10.1159/000369068 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - January 17, 2015 Category: Urology & Nephrology Authors: Koichiro Homma Tadashi Yoshida Maho Yamashita Kei Hayashida Matsuhiko Hayashi Shingo Hori Source Type: research
Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats
Conclusion: Results suggest that H2 gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cell apoptosis and oxidative stress. © 2015 S. Karger AG, Basel.PMID:25592271 | DOI:10.1159/000369068 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - January 17, 2015 Category: Urology & Nephrology Authors: Koichiro Homma Tadashi Yoshida Maho Yamashita Kei Hayashida Matsuhiko Hayashi Shingo Hori Source Type: research
Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats
Conclusion: Results suggest that H2 gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cell apoptosis and oxidative stress. © 2015 S. Karger AG, Basel.PMID:25592271 | DOI:10.1159/000369068 (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - January 17, 2015 Category: Urology & Nephrology Authors: Koichiro Homma Tadashi Yoshida Maho Yamashita Kei Hayashida Matsuhiko Hayashi Shingo Hori Source Type: research
