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Specialty: Allergy & Immunology

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Total 1296 results found since Jan 2013.

Silenced suppressor of cytokine signaling 1 (SOCS1) enhances the maturation and antifungal immunity of dendritic cells in response to Candida albicans in vitro
In conclusion, our findings support the view that SOCS1 protein is a critical inhibitory molecule for controlling cytokine response and antigen presentation by DCs, thereby regulating the magnitude of innate and adaptive immunities by generating IFN-γ-production T cells (Th1)—but not Th17—from naïve CD4+ T cells. Our study demonstrates that SOCS1 siRNA can serve as a useful vehicle to modulate the function of DCs against C. albicans infection.
Source: Immunologic Research - November 9, 2014 Category: Allergy & Immunology Source Type: research

Impact of suppressing retinoic acid‐related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity
In this study, we characterized the correlation between RORγt expression and other factors affecting T cell encephalitogenicity and evaluated the therapeutic potential of targeting RORγt by siRNA inhibition of RORγt. Our data showed that RORγt expression correlates with interleukin (IL)‐17 production, but not with the encephalitogenicity of myelin‐specific CD4 T cells. IL‐23, a cytokine that enhances encephalitogenicity, does not enhance RORγt expression significantly. Additionally, granulocyte–macrophage colony‐stimulating factor (GM‐CSF) levels, which correlate with the encephalitogenicity of different m...
Source: Clinical and Experimental Immunology - November 26, 2014 Category: Allergy & Immunology Authors: Y. Yang, R. C. Winger, P. W. Lee, P. K. Nuro‐Gyina, A. Minc, M. Larson, Y. Liu, W. Pei, E. Rieser, M. K. Racke, A. E. Lovett‐Racke Tags: Original Article Source Type: research

Activation of Nicotinic Receptors Inhibits TNF-α-Induced Production of Pro-inflammatory Mediators Through the JAK2/STAT3 Signaling Pathway in Fibroblast-Like Synoviocytes
In conclusion, nicotine has an anti-inflammatory effect on RA by downregulating production of IL-6 and MCP-1 in FLSs, and this is mediated through activation of the JAK2–STAT3 signal pathway.
Source: Inflammation - January 23, 2015 Category: Allergy & Immunology Source Type: research

The Stress‐responsive Heme Oxygenase (HO)‐1 Isoenzyme is Increased in Labouring Myometrium where it Regulates Contraction‐associated Proteins
ConclusionCollectively, these findings in myometrium indicate HO‐1 expression is increased with labour and exerts pro‐inflammatory effects via NF‐κB during cytokine‐ and TLR ligand‐induced inflammation.
Source: American Journal of Reproductive Immunology - February 1, 2015 Category: Allergy & Immunology Authors: Stella Liong, Martha Lappas Tags: Original Article Source Type: research

Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model
Conclusion: CRMP2 is highly expressed in M1 macrophages and silencing CRMP2 reprograms macrophage phenotype and improves infarct healing in atherosclerotic mice.
Source: Journal of Inflammation - February 10, 2015 Category: Allergy & Immunology Authors: Long-Shu ZhouGuo-Long ZhaoQiang LiuShu-Cai JiangYun WangDong-Mei Zhang Source Type: research

Downregulating galectin-3 inhibits proinflammatory cytokine production by human monocyte-derived dendritic cells via RNA interference.
Abstract Galectin-3 (Gal-3), a β-galactoside-binding lectin, serves as a pattern-recognition receptor (PRR) of dendritic cells (DCs) in regulating proinflammatory cytokine production. Galectin-3 (Gal-3) siRNA downregulates expression of IL-6, IL-1β and IL-23 p19, while upregulates IL-10 and IL-12 p35 in TLR/NLR stimulated human MoDCs. Furthermore, Gal-3 siRNA-treated MoDCs enhanced IFN-γ production in SEB-stimulated CD45RO CD4 T-cells, but attenuated IL-17A and IL-5 production by CD4 T-cells. Addition of neutralizing antibodies against Gal-3, or recombinant Gal-3 did not differentially modulate IL-23 p19 versus...
Source: Cellular Immunology - February 7, 2015 Category: Allergy & Immunology Authors: Chen SS, Sun LW, Brickner H, Sun PQ Tags: Cell Immunol Source Type: research

Overexpression and Potential Regulatory Role of IL-17F in Pathogenesis of Chronic Periodontitis
This study indicates that IL-17F may be involved in pathogenesis of periodontitis like IL-17A. The role of IL-17F in disease pathogenesis needs to be further investigated.
Source: Inflammation - May 8, 2015 Category: Allergy & Immunology Source Type: research

Ox-LDL Upregulates IL-6 Expression by Enhancing NF-κB in an IGF2-Dependent Manner in THP-1 Macrophages
Abstract Interleukin 6 (IL-6) is a pro-inflammatory cytokine that is well established as a vital factor in determining the risk of coronary heart disease and pathogenesis of atherosclerosis. Moreover, accumulating evidences have shown that oxidized low-density lipoprotein (ox-LDL) can promote IL-6 expression in macrophages. Nevertheless, the underlying mechanism of how ox-LDL upregulates IL-6 expression remains largely unexplained. We found that the expression of insulin-like growth factor 2 (IGF2), nuclear factor kappa B (NF-κB), and IL-6 was upregulated at both the messenger RNA (mRNA) and protein levels in a d...
Source: Inflammation - June 12, 2015 Category: Allergy & Immunology Source Type: research

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus.
In this study, we aimed to investigate whether apoptosis of BM-MSCs from SLE patients were dysregulated. In this paper, endoplasmic reticulum stress (ERS) was evidenced by increased expression of phosphorylated protein kinase RNA-like ER kinase (PERK) and inositol-requiring protein-1 (IRE-1). We also found the activation of downstream target eukaryotic translation initiator factor 2α (eIF 2α) and CCAAT/enhancer-binding protein- (C/EBP-) homologous protein (CHOP) in BM-MSCs from SLE patients. Interestingly, we discovered that 4-phenylbutyric acid (4-PBA), a selective inhibitor of ERS, blocked the apoptosis of BM-MSCs from...
Source: Journal of Immunology Research - June 22, 2015 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Wnt1 Participates in Inflammation Induced by Lipopolysaccharide Through Upregulating Scavenger Receptor A and NF-kB
Abstract The study investigated the role of wnt1 in the inflammatory response initiated by lipolysaccharide (LPS), and analyzed the association between wnt1, NF-KB, and inflammatory factors. THP-1 cells were activated with phorbol-12-myristate-13-acetate (PMA) and treated with LPS to induce inflammation. THP-1 cells were transfected with wnt1siRNA and overexpression plasmid to explore the relationship among wnt1, SRA, and NF-KB. Inhibitor of β-catenin and siRNA of FZD1were used to investigate the signaling events involved in SRA activation induced by wnt1. Levels of NF-kB protein and inflammatory cytokines were ...
Source: Inflammation - July 8, 2015 Category: Allergy & Immunology Source Type: research

ADAM10 mediates the house dust mite‐induced release of chemokine ligand CCL20 by airway epithelium
ConclusionOur data show for the first time that ADAM10 activity contributes to HDM‐induced shedding of chemokines, including CCL20. The ADAM10/CCL20 axis may be a target for novel therapeutic strategies in asthma.This article is protected by copyright. All rights reserved.
Source: Allergy - January 1, 2015 Category: Allergy & Immunology Authors: Sijranke Post, Dennie Rozeveld, Marnix Jonker, Rainer Bischoff, Antoon Oosterhout, Irene Heijink Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells.
In this study, GP significantly attenuated inflammation in acute liver injury (ALI) mice model and in lipopolysaccharide (LPS)-induced THP-1 cells. It was demonstrated that GP obviously decreased the expression of Methyl-CpG binding protein 2 (MeCP2) in vivo and in vitro. Knockdown of MeCP2 with siRNA suppressed the expressions of IL-6 and TNF-α, while over-expression of MeCP2 had a proinflammatory effect on the expression of IL-6 and TNF-α in LPS-induced THP-1 cells. Mechanistically, it was indicated that GP had anti-inflammatory effects at least in part, through suppressing MeCP2. Interestingly, GP could attenuate expr...
Source: International Immunopharmacology - September 11, 2015 Category: Allergy & Immunology Authors: Ma TT, Li XF, Li WX, Yang Y, Huang C, Meng XM, Zhang L, Li J Tags: Int Immunopharmacol Source Type: research

Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway
Conclusions: This is the first study to illustrate that EsA acts as a novel Nrf-2 activator, which modulates the oxidative stress pathway to improve lung injury and ameliorate the development of airway inflammation.Int Arch Allergy Immunol 2015;167:280-290
Source: International Archives of Allergy and Immunology - October 24, 2015 Category: Allergy & Immunology Source Type: research

Alternaria Induces Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2.
CONCLUSIONS: The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps. PMID: 26540503 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 7, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

TLR4-mediated IRAK1 activation induces TNF-{alpha} expression via JNK-dependent NF-{kappa}B activation in human bronchial epithelial cells
The purpose of this study was to identify the mechanism of lipopolysaccharide (LPS)-induced expression of tumor necrosis factor (TNF)-α in BEAS-2B. Toll-like receptor (TLR)4-specific siRNA was found to completely abolish the LPS-induced expression of MyD88 and TNF-α. There was enhanced binding of MyD88 with IRAK1 following LPS treatment, and MyD88- or IRAK1-specific siRNAs decreased the expression of TNF-α. In addition, IRAK1 siRNA downregulated the phosphorylation of PKCα, demonstrating that PKCα is a downstream effector of IRAK1. Inhibition of PKCα completely blocked the activation of ...
Source: European Journal of Inflammation - November 26, 2015 Category: Allergy & Immunology Authors: Park, S. H., Choi, H.-J., Lee, S. Y., Han, J.-S. Tags: Original articles Source Type: research