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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants
Innate Immun. 2021 Jun 18:17534259211018740. doi: 10.1177/17534259211018740. Online ahead of print.ABSTRACTTLRs recognizing PAMPS play a role in local immunity and participate in implant-associated loosening. TLR-mediated signaling is primarily regulated by IL-1 receptor associated kinase-M (IRAK-M) negatively and IRAK-4 positively. Our previous studies have proved that wear particles promote endotoxin tolerance in macrophages by inducing IRAK-M. However, whether IRAK-4 is involved in inflammatory osteolysis of wear particles basically, and the specific mechanism of IRAK-4 around loosened hip implants, is still unclear. IR...
Source: Innate Immunity - June 18, 2021 Category: Allergy & Immunology Authors: Yang-Chun Zhang Jian-Hong Xiao Shao-Jie Deng Guo-Liang Yi Source Type: research
Connecting Metabolism to Mastitis: Hyperketonemia Impaired Mammary Gland Defenses During a Streptococcus uberis Challenge in Dairy Cattle
β-hydroxybutyrate (BHB) has been associated with disease incidence in early lactation dairy cattle, but such associations do not demonstrate causation. Therefore, the objective of this study was to examine the effects of BHB during an intramammary Streptococcus uberis challenge. A secondary objective was to elucidate the mechanisms behind BHB effects on cytokine transcript abundance using the RAW 264.7 cell line. Late lactation multiparous dairy cows (n = 12) were continuously infused intravenously with either BHB to induce hyperketonemia (target concentration: 1.8 mM) or with saline (CON) for 72 h during a S. uberis int...
Source: Frontiers in Immunology - June 29, 2021 Category: Allergy & Immunology Source Type: research
IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants
Innate Immun. 2021 Jun 18:17534259211018740. doi: 10.1177/17534259211018740. Online ahead of print.ABSTRACTTLRs recognizing PAMPS play a role in local immunity and participate in implant-associated loosening. TLR-mediated signaling is primarily regulated by IL-1 receptor associated kinase-M (IRAK-M) negatively and IRAK-4 positively. Our previous studies have proved that wear particles promote endotoxin tolerance in macrophages by inducing IRAK-M. However, whether IRAK-4 is involved in inflammatory osteolysis of wear particles basically, and the specific mechanism of IRAK-4 around loosened hip implants, is still unclear. IR...
Source: Innate Immunity - June 18, 2021 Category: Allergy & Immunology Authors: Yang-Chun Zhang Jian-Hong Xiao Shao-Jie Deng Guo-Liang Yi Source Type: research
