Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages
Innate Immun. 2021 Apr;27(3):275-284. doi: 10.1177/17534259211005840.ABSTRACTTLRs, including TLR4, play a crucial role in inflammatory-based diseases, and TLR4 has been identified as a therapeutic target for pharmacological intervention. In previous studies, we investigated the potential of FP7, a novel synthetic glycolipid active as a TLR4 antagonist, to inhibit haematopoietic and non-haematopoietic MyD88-dependent TLR4 pro-inflammatory signalling. The main aim of this study was to investigate the action of FP7 and its derivative FP12 on MyD88-independent TLR4 signalling in THP-1 derived macrophages. Western blotting, Ab ...
Source: Innate Immunity - April 16, 2021 Category: Allergy & Immunology Authors: Charys Palmer Fabio A Facchini Richard Po Jones Frank Neumann Francesco Peri Grisha Pirianov Source Type: research

A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis
Innate Immun. 2021 Apr;27(3):266-274. doi: 10.1177/17534259211007538.ABSTRACTDespite the dramatic increase in antimicrobial resistance, there is a dearth of antibiotics in development and few pharmaceutical companies working in the field. Further, any new antibiotics are likely to have a short shelf life. Ab-based interventions offer alternatives that are not likely to be circumvented by the widely prevalent antibiotic resistance genes. Bovine colostrum (BC)-the first milk after parturition, rich in nutrients and immune components-promotes gut integrity and modulates the gut microbiome. We developed a hyperimmune BC (HBC) ...
Source: Innate Immunity - April 16, 2021 Category: Allergy & Immunology Authors: Alan S Cross Steven M Opal John E Palardy Surekha Shridhar Scott M Baliban Alison J Scott Abdullah B Chahin Robert K Ernst Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Apr;27(3):212-229. doi: 10.1177/17534259211001512. Epub 2021 Mar 24.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic granules, d...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Human NK cells: From development to effector functions
Innate Immun. 2021 Mar 24:17534259211001512. doi: 10.1177/17534259211001512. Online ahead of print.ABSTRACTNK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop mechanisms to distinguish self from non-self during the process of NK cell education. Unlike T and B cells, natural killer cells lack clonotypic receptors and are activated after recognizing their target via germline-encoded receptors through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Subsequently, they utilize cytotoxic...
Source: Innate Immunity - March 25, 2021 Category: Allergy & Immunology Authors: Arosh Shavinda Perera Molligoda Arachchige Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity
Innate Immun. 2021 Mar 1:1753425921995577. doi: 10.1177/1753425921995577. Online ahead of print.ABSTRACTCell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined...
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Reham Hammad Mona Abd El Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud Source Type: research

< em > Haemophilus influenza < /em > e causes cellular trans-differentiation in human bronchial epithelia
In this study we show a direct pathogen-induced trans-differentiation of primary bronchial epithelial cells resulting in a co-localization of epithelial and mesenchymal markers and an up-regulation of extracellular matrix components.PMID:33646896 | DOI:10.1177/1753425921994906 (Source: Innate Immunity)
Source: Innate Immunity - March 1, 2021 Category: Allergy & Immunology Authors: Michael Gl öckner Sebastian Marwitz Kristina Rohmann Henrik Watz D örte Nitschkowski Jan Rupp Klaus Dalhoff Torsten Goldmann Daniel Dr ömann Source Type: research

Anti-nociceptive effect of < em > Portulaca oleracea < /em > L. ethanol extracts attenuated zymosan-induced mouse joint inflammation via inhibition of Nrf2 expression
Innate Immun. 2021 Feb 20:1753425921994190. doi: 10.1177/1753425921994190. Online ahead of print.ABSTRACTThe aim of this study was to explore the effects of ethanol extracts from Portulaca oleracea L. (ePO) on joint inflammation and to explain the underlying mechanisms. A joint inflammation mouse model was constructed by injecting zymosan, and the Von Frey method was employed and the joint thickness measured. The numbers of leukocytes, neutrophils, and monocytes were counted in the joint cavity and the infiltration of inflammatory cells was assessed by joint histopathological analysis. The mRNA levels of inflammatory cytok...
Source: Innate Immunity - February 22, 2021 Category: Allergy & Immunology Authors: Yunwu He Hui Long Cong Zou Wuzhou Yang Liping Jiang Zhenping Xiao Qing Li Shiyin Long Source Type: research