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Specialty: Allergy & Immunology

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Total 1296 results found since Jan 2013.

Isoflurane preconditioning ameliorates electromagnetic pulse-induced neural damage by shifting microglia polarization toward anti-inflammatory phenotype via upregulation of SOCS1.
Abstract With the speedy technological advances during the past few decades, human exposure to the electromagnetic field (EMF) has become increasingly common. Exposure to EMF may induce neural injuries and dysfunction of various organs, likely involving neuroinflammation and activation of microglial cells. Isoflurane preconditioning (IP) is shown to provide neuroprotection in various neurological diseases by inhibiting excessive neuroinflammatory responses. Brain samples harvested from rats exposed to electromagnetic pulse (EMP) with or without IP were subjected to qPCR, Western blot assay, and immunohistochemistr...
Source: International Immunopharmacology - January 2, 2019 Category: Allergy & Immunology Authors: Zhang X, Lv M, Zhu X, Tian L, Li J, Shao Y, Gao C, Sun X Tags: Int Immunopharmacol Source Type: research

NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro.
Abstract Oxidative stress and inflammation are closely related to neuron ageing. NADPH oxidase 2 (NOX2) is a major source of reactive oxygen species (ROS) generation in brain. The nucleotide-binding oligomerisation domain (NOD)-like receptor protein 1 (NLRP1) inflammasome is responsible for the formation of proinflammatory molecules in neurons. We hypothesize that NOX2-derived ROS accumulation mediates activation of NLRP1 inflammasome, which is involved in age-related neuronal damage. In the present study, we investigated the changes of NOX2-NLRP1 signaling pathway in primary hippocampal neurons cultured for diffe...
Source: International Immunopharmacology - January 21, 2019 Category: Allergy & Immunology Authors: Xu T, Sun L, Shen X, Chen Y, Yin Y, Zhang J, Huang D, Li W, Li W Tags: Int Immunopharmacol Source Type: research

Inhibition of GSK-3 β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
In this study, we examined whether NLRP3 inflammasome-derived inflammation could be ameliorated by GSK-3β inhibition in a cerebral ischemia reperfusion injury model and assessed whether autophagy is involved in this process. To establish ischemic reperfusion injury, we used a middle cerebral artery occlusion-reperfusion (MCAO/R) model in rats. A chemical inhibitor (SB216763) and GSK-3β siRNA were used to suppress GSK-3β activation and GSK-3β expression in vivo. The results demonstrated that SB216763 and GSK-3β siRNA improved neurological scores, reduced cerebral infarct volume, and decreased the levels of NLRP3 inflam...
Source: International Immunopharmacology - January 28, 2019 Category: Allergy & Immunology Authors: Wang Y, Meng C, Zhang J, Wu J, Zhao J Tags: Int Immunopharmacol Source Type: research

Semaphorin 3F Promotes Transendothelial Migration of Leukocytes in the Inflammatory Response After Survived Cardiac Arrest
AbstractLeukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology. Herein, we assess the role of Sema3F in leukocyte migrationin vitro andin vivo. To determine the impact of Sema3F on leukocyte recruitmentin vivo, we used the thioglycollate-induced peritonitis model. After the induction of peritonitis, C57BL/6 mice were intraperitoneally (i.p.) injected daily with recombinant Sema3F or s...
Source: Inflammation - March 14, 2019 Category: Allergy & Immunology Source Type: research

Role of the ciRS-7/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1 β.
In this study, quantitative reverse-transcription PCR (qRT-PCR) was utilized to determine the relative expression of ciRS-7 and miR-7 in blood samples from OA patients compared with those from healthy individuals. Human OA chondrocytes (C28/12 cell line) were transfected with ciRS-7-siRNA, ciRS-7-cDNA, inhibitor or miR-7 mimic to investigate the influence of ciRS-7/miR-7 expression on chondrocyte apoptosis, inflammation and related signaling pathways. Decreased ciRS-7 expression and increased miR-7 expression were observed in OA blood samples. IL-1β exposure of chondrocytes significantly inhibited proliferation and promot...
Source: International Immunopharmacology - March 25, 2019 Category: Allergy & Immunology Authors: Zhou X, Jiang L, Fan G, Yang H, Wu L, Huang Y, Xu N, Li J Tags: Int Immunopharmacol Source Type: research

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1 β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor
Management of pain in the treatment of rheumatoid arthritis (RA) is a priority that is not fully addressed by the conventional therapies. In the present study, we evaluated the efficacy of cannabinoid receptor 2 (CB2) agonist JWH-015 using RA synovial fibroblasts (RASFs) obtained from patients diagnosed with RA and in a rat adjuvant-induced arthritis (AIA) model of RA. Pretreatment of human RASFs with JWH-015 (10-20 µM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1β (IL-1β) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2). JWH-015 was effe...
Source: Frontiers in Immunology - May 7, 2019 Category: Allergy & Immunology Source Type: research

Arsenic trioxide improves Treg and Th17 balance by modulating STAT3 in treatment-na ïve rheumatoid arthritis patients.
CONCLUSIONS: These data indicate that As2O3 may be a potential immune modulator for treatment-naïve RA patients that helps to balance of Treg and Th17 cells through modulating STAT3. PMID: 31177080 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - June 5, 2019 Category: Allergy & Immunology Authors: Li C, Zhang J, Wang W, Wang H, Zhang Y, Zhang Z Tags: Int Immunopharmacol Source Type: research

Inhibition of NOX2-NLRP1 signaling pathway protects against chronic glucocorticoids exposure-induced hippocampal neuronal damage.
In this study, the lentivirus with NLRP1-siRNA was injected into the hippocampus of male mice which were then treated with dexamethasone (DEX, 5 mg/kg) for 28 d. The data indicated that NLRP1-siRNA treatment down-regulated the NLRP1 expression and significantly improved the exploratory behavior and spatial memory deficits in open field tests and Morris water maze which were deteriorated by chronic DEX treatment in mice. Additionally, inhibition of NLRP1 expression significantly alleviated neuronal degeneration and increased MAP2 expression in the hippocampus in mice. Meanwhile, the results showed that DEX exposure incr...
Source: International Immunopharmacology - June 26, 2019 Category: Allergy & Immunology Authors: Sun L, Chen Y, Shen X, Xu T, Yin Y, Zhang H, Ding S, Zhao Y, Zhang Y, Guan Y, Li W Tags: Int Immunopharmacol Source Type: research

Downregulation of lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson's disease through the inhibition of the PI3K/Akt signaling pathway.
This study is conducted to investigate the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in the protection of dopaminergic neurons in Parkinson's disease (PD) through regulating the PI3K/Akt signaling pathway. PD rat model was induced by injection of 6-hydroxydopamine (6-OHDA) to damage the substantia nigra striatum. The successfully modeled PD rats were introduced with siRNA-negative control (NC) or UCA1-siRNA. The expression of UCA1 in neurobehavioral change, neuroinflammatory response and oxidative stress of PD rats were explored. The effect of UCA1 on the PI3K/Akt signaling pathway and downstream proteins Iκ...
Source: International Immunopharmacology - July 8, 2019 Category: Allergy & Immunology Authors: Cai L, Tu L, Li T, Yang X, Ren Y, Gu R, Zhang Q, Yao H, Qu X, Wang Q, Tian J Tags: Int Immunopharmacol Source Type: research

RNAi Transfection Optimized in Primary Na ïve B Cells for the Targeted Analysis of Human Plasma Cell Differentiation
This study reports a validated non-viral method of siRNA delivery into human primary B cells that can be applied to study gene regulatory networks that control human ASC differentiation.
Source: Frontiers in Immunology - July 22, 2019 Category: Allergy & Immunology Source Type: research

Blockage of immune checkpoint molecules increases T cell priming potential of dendritic cell vaccine.
In this study, we silenced the expression of PD-L1 in DCs and PD-1 in T cells by siRNA-loaded chitosan-dextran sulfate nanoparticles (NPs) and evaluated the DC phenotypic and functional characteristics and T cells functions following tumor antigen recognition on DCs, ex vivo. Our results showed that synthesized NPs had good physicochemical characteristics (size of 77.5 nm and zeta potential of 14.3) that was associated with efficient cellular uptake and target gene silencing. Moreover, PD-L1 silencing was associated with stimulatory characteristics of DCs. On the other hand, presentation of tumor antigens by PD-L1 negative...
Source: Immunology - October 5, 2019 Category: Allergy & Immunology Authors: Hassannia H, Ghasemi Chaleshtari M, Atyabi F, Nosouhian M, Masjedi A, Hojjat-Farsangi M, Namdar A, Azizi G, Mohammadi H, Ghalamfarsa G, Sabz G, Hasanzadeh S, Yousefi M, Jadidi-Niaragh F Tags: Immunology Source Type: research

Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate –activated protein kinase pathway in nasal fibroblasts
ConclusionCSE has an inhibitory effect on cell migration and collagen gel contraction activity via the ROS/AMPK signaling pathway in nasal fibroblasts.
Source: International Forum of Allergy and Rhinology - November 5, 2019 Category: Allergy & Immunology Authors: Jae ‐Min Shin, Joo‐Hoo Park, Hyun‐Woo Yang, Heung‐Man Lee, Il‐Ho Park Tags: ORIGINAL ARTICLE Source Type: research

Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases
Human lung fibroblasts (HLFs) treated with the viral mimetic polyinosine-polycytidylic acid (poly I:C) form an extracellular matrix (ECM) enriched in hyaluronan (HA) that avidly binds monocytes and lymphocytes. Mast cells are important innate immune cells in both asthma and acute respiratory infections including respiratory syncytial virus (RSV); however, the effect of RSV on HA dependent mast cell adhesion and/or function is unknown. To determine if RSV infection of HLFs leads to the formation of a HA-enriched ECM that binds and enhances mast cell activity primary HLFs were infected with RSV for 48 h prior to leukocyte bi...
Source: Frontiers in Immunology - January 27, 2020 Category: Allergy & Immunology Source Type: research

Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D
The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP). We evaluated the effects of N-acetylgalactosamine (GalNAc)-conjugated MASP-1 and MASP-2 duplexes in vitro and in mice with and without arthritis to examine whether knockdown of MASP-1 and MASP-2 expression affects the development of arthritis. GalNAc-siRNAs for MASP-1 and MASP-2 demonstrated robust silencing of MASP-1 or MASP-2 at pM concentrations in...
Source: Frontiers in Immunology - February 20, 2020 Category: Allergy & Immunology Source Type: research