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Specialty: Allergy & Immunology

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Total 1296 results found since Jan 2013.

A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders
Conclusions: Our results identified a new nucleic acid–based agent (CD8 aptamer–GNLY siRNA chimera) that can significantly inhibit CTL-mediated drug hypersensitivity, such as that seen in patients with SJS/TEN, as well as the alloreactivity seen in patients with GVHD. This study provides a novel therapeutic strategy for CTL-mediated immune disorders.
Source: Journal of Allergy and Clinical Immunology - June 21, 2013 Category: Allergy & Immunology Authors: Chuang-Wei Wang, Wen-Hung Chung, Yi-Fang Cheng, Nien-Wen Ying, Konan Peck, Yuan-Tsong Chen, Shuen-Iu Hung Tags: Mechanisms of allergy and clinical immunology Source Type: research

CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and Th17 response.
Abstract The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CARD11-targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3d after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and micro-computed tomography (mic...
Source: Clinical and Developmental Immunology - January 20, 2014 Category: Allergy & Immunology Authors: Wang H, Zhao J, Zhang H, Huang Y, Wang S, Tu Q, Yang N Tags: Clin Exp Immunol Source Type: research

CCR5 small interfering RNA ameliorated joint inflammation in rats with adjuvant-induced arthritis.
Abstract Rheumatoid arthritis (RA) is a systemic inflammatory disease. C-C chemokine receptor type 5 (CCR5) is found in inflamed synovium of RA patients and is necessary for formation of RA. We aimed to check whether delivery of CCR5-specific small interfering RNA (siRNA) via electroporation suppresses local inflammation in arthritis rats. Vectors encoding siRNA that target CCR5 or negative control siRNA were constructed for gene silencing and the silencing effects of suppressing CCR5 expression in synovium examined by western blot. The vector with strongest effect was delivered into the knee joint of adjuvant-ind...
Source: Immunology Letters - October 7, 2014 Category: Allergy & Immunology Authors: Duan H, Yang P, Fang F, Ding S, Xiao W Tags: Immunol Lett Source Type: research

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aime...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
We described a new defense mechanism based on IFIT5 antiviral activity in nucleated RBCs that appeared to contribute to halting the VHSV infection. This finding sheds light into novel antiviral therapeutics to mitigate the economic losses and social impact caused by viral infections in the aquaculture industry. This work broadens the knowledge of fish nucleated RBCs functions and their role in the immune response to viral infections. Ethics Statement Experimental protocols and methods relating to experimental animals were reviewed and approved by the Animal Welfare Body and the Research Ethics Committee at the University...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

CARD11 blockade suppresses murine collagen‐induced arthritis via inhibiting CARD11/Bcl10 assembly and Th17 response
Summary The scaffold protein caspase recruitment domain‐containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen‐induced arthritis (CIA) were treated with either CARD11‐targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3d after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and micro‐computed tomography (micro...
Source: Clinical and Experimental Immunology - January 21, 2014 Category: Allergy & Immunology Authors: Hongyue Wang, Jijun Zhao, Hui Zhang, Yuefang Huang, Shuang Wang, Qingqiang Tu, Niansheng Yang Tags: Original Article Source Type: research

Inhibition of Interferon Regulatory Factor 4 Attenuates Acute Liver Allograft Rejection in Mice
In conclusion, inhibition of IRF4 attenuates acute liver allograft rejection in mice, and this is associated with promoted M2 macrophage differentiation. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - June 12, 2015 Category: Allergy & Immunology Authors: Wei Zhao, Zhong Zhang, Qingjun Zhao, Mengjie Liu, Yuelan Wang Tags: Regular Article Source Type: research

Nanotherapy Silencing the Interleukin-8 Gene Produces Regression of Prostate Cancer by Inhibition of Angiogenesis.
This study examines the role of IL-8 in the pathogenesis of metastatic prostate cancer. We developed a biocompatible, cationic polylactide (CPLA) nanocarrier to complex with and efficiently deliver IL-8 siRNA to CaP cells in vitro and in vivo. CPLA IL-8 siRNA nanocomplexes (nanoplexes) protect siRNA from rapid degradation, are nontoxic, have a prolonged lifetime in circulation, and their net positive charge facilitates penetration of cell membranes and subsequent intracellular trafficking. Administration of CPLA IL-8 siRNA nanoplexes to immunodeficient mice bearing human CaP tumors produced significant antitumor activities...
Source: Immunology - May 8, 2016 Category: Allergy & Immunology Authors: Aalinkeel R, Nair B, Chen CK, Mahajan SD, Reynolds JL, Zhang H, Sun H, Sykes DE, Chadha KC, Turowski SG, Bothwell KD, Seshadri M, Chen C, Schwartz SA Tags: Immunology Source Type: research

The role of autophagy in the overexpression of MUC5AC in patients with chronic rhinosinusitis.
CONCLUSIONS: In HNE-induced CRS, autophagy increases the secretion of MUC5AC by promoting the phosphorylation of JNK and c-Jun. PMID: 30909132 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - March 21, 2019 Category: Allergy & Immunology Authors: Ye Y, Zhao J, Ye J, Jiang X, Liu H, Xie Y, Zhang J, Luo Q Tags: Int Immunopharmacol Source Type: research

GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress
CONCLUSION: According to the results of this study, GRK2 participated in cardiac hypertrophy induced by ISO by mitigating NLRP3 inflammasome and oxidative stress through the signaling of Nrf2 in H9c2 cells.PMID:37012864 | DOI:10.1016/j.intimp.2023.109957
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Jing Liu Xiaoli Li Lu Ding Wei Li Xiaolin Niu Dengfeng Gao Source Type: research

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
Conclusions: Our data indicate that siRNAs activate endosomal Toll-like receptors in different liver-derived cell types to various degrees, in vitro. LNP-formulated siRNA selectively leads to hepatic knock-down of target genes in vivo. Here, off-target immune responses are restricted to non-parenchymal liver cells. However, 2'-O-methyl modifications of siRNA largely avoid immune-stimulatory effects, which is a crucial prerequisite for the development of safe and efficient RNA-interference-based therapeutics.
Source: International Immunology - January 28, 2014 Category: Allergy & Immunology Authors: Broering, R., Real, C. I., John, M. J., Jahn-Hofmann, K., Ickenstein, L. M., Kleinehr, K., Paul, A., Gibbert, K., Dittmer, U., Gerken, G., Schlaak, J. F. Tags: featured content Source Type: research

Cadmium induces mucin 8 expression via Toll‐like receptor 4–mediated extracellular signal related kinase 1/2 and p38 mitogen‐activated protein kinase in human airway epithelial cells
ConclusionThe results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4‐mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.
Source: International Forum of Allergy and Rhinology - January 1, 2016 Category: Allergy & Immunology Authors: Si‐Youn Song, Chang Hoon Bae, Yoon Seok Choi, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

A novel role for RGMa in modulation of bone marrow-derived dendritic cells maturation induced by lipopolysaccharide.
Abstract Repulsive guidance molecule a (RGMa) is known to mediate immune responses and has been indicated to modulates T cell activation and autoimmune diseases by dendritic cells (DCs), which hints its significant function in the latter cells. The aim of our study, therefore, was to evaluate the function of RGMa in DC maturation. We found that small interfering RNA (siRNA) successfully silenced the expression of RGMa in DCs. Even after LPS stimulation, RGMa-silenced DCs displayed an immature morphology, characterized by small, round cells with a few cell processes and organelles, and many pinocytotic vesicles. In...
Source: International Immunopharmacology - February 17, 2016 Category: Allergy & Immunology Authors: Xu X, Gao Y, Shan F, Feng J Tags: Int Immunopharmacol Source Type: research