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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress
Int J Endocrinol. 2022 Sep 21;2022:6073911. doi: 10.1155/2022/6073911. eCollection 2022.ABSTRACTDiabetic nephropathy (DN) has become the most common secondary kidney disease causing end-stage renal disease (ESRD). Nevertheless, the underlying mechanisms responsible for DN remain largely unknown. Regulated in development and DNA damage response 1 (REDD1) is a prooxidative molecule known to contribute to diabetes mellitus and its complications. However, it has not been previously examined whether and how REDD1 can further drive renal tubular epithelial cell (RTEC) apoptosis and epithelial-to-mesenchymal transition in DN. The...
Source: International Journal of Endocrinology - October 3, 2022 Category: Endocrinology Authors: Lin Mu Nan Chen Yakun Chen Zhifen Yang Huandi Zhou Shan Song Yonghong Shi Source Type: research
Targeting tumor hypoxia inhibits aggressive phenotype of dedifferentiated thyroid cancer
CONCLUSIONS: Hypoxia score serves as a significant indicator for dedifferentiation status, prognoses and immunotherapeutic response predicted by Tumor Immune Dysfunction and Exclusion in DDTC patients. Targeting hypoxia by ACF is useful to alleviate aggressive phenotype of ATC in pre-clinical model of DDTC.PMID:36190930 | DOI:10.1210/clinem/dgac548
Source: The Journal of Clinical Endocrinology and Metabolism - October 3, 2022 Category: Endocrinology Authors: Ben Ma Shishuai Wen Yi Luo Tingting Zhang Yichen Yang Cenkai Shen Yan Zhang Qinghai Ji Ning Qu Yu Wang Source Type: research
Laminin- α4 negatively regulates adipocyte beiging through the suppression of AMPKα in male mice
Endocrinology. 2022 Sep 19:bqac154. doi: 10.1210/endocr/bqac154. Online ahead of print.ABSTRACTLaminin-α4 (LAMA4) is an extracellular matrix protein implicated in the regulation of adipocyte differentiation and function. Prior research describes a role for LAMA4 in modulating adipocyte thermogenesis and uncoupling protein-1 (UCP1) expression in white adipose; however, the mechanisms involved are poorly understood. Here, we describe that Lama4 knockout mice (Lama4-/-) exhibit heightened mitochondrial biogenesis and peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) expression in subcutaneous white adipo...
Source: Endocrinology - September 20, 2022 Category: Endocrinology Authors: Anna Goddi Alanis Carmona Soo Young Park Gokhan Dalgin Maria A Gonzalez Porras Eric M Brey Ronald N Cohen Source Type: research
Multiple tachykinins and their receptors characterized in the gastropod mollusk Pacific abalone: Expression, signaling cascades, and potential role in regulating lipid metabolism
This study identified two TK precursors and two TKR isoforms in the Pacific abalone Haliotis discus hannai (Hdh), and characterized Hdh-TK signaling. Hdh-TK peptides harbored protostomian TK-specific FXGXRamide or unique YXGXRamide motifs at the C-termini. A phylogenetic analysis showed that lophotrochozoan TKRs, including Hdh-TKRs, form a monophyletic group distinct from arthropod TKRs and natalisin receptor groups. Although reporter assays demonstrated that all examined Hdh-TK peptides activate intracellular cAMP accumulation and Ca2+ mobilization in Hdh-TKR-expressing mammalian cells, Hdh-TK peptides with N-terminal aro...
Source: Frontiers in Endocrinology - September 12, 2022 Category: Endocrinology Source Type: research
Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease
In this study, we investigated the role of MIF in regulating JNK activation and high-fat fostered liver lipotoxicity during simultaneous exercise treatment. Fifteen mice were equally divided into three groups: normal diet, high-fat diet, and high-fat and exercise groups. High-fat feeding for extended periods elicited evident hyperlipemia, liver steatosis, and cell apoptosis in mice, with inhibited MIF and activated downstream MAPK kinase 4 phosphorylation and JNK. These effects were then reversed following prescribed swimming exercise, indicating that the advent of exercise could prevent liver lipotoxicity induced by lipid...
Source: Frontiers in Endocrinology - September 6, 2022 Category: Endocrinology Source Type: research
Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation
In this report, the expression of the enzyme responsible for L2HG degradation, L-2HG dehydrogenase (L2HGDH), is knocked down, using lentiviral shRNA, as well as siRNA, in primary cultures of normal Renal Proximal Tubule (RPT) cells. The knockdown (KD) results in increased L-2HG levels, decreased demethylation of 5mC in genomic DNA, and increased methylation of H3 Histones. Consequences include reduced tubulogenesis by RPT cells in matrigel, and reduced expression of molecular markers of differentiation, including membrane transporters as well as HNF1α and HNF1β, which regulate their transcription. These results are consi...
Source: Frontiers in Endocrinology - September 5, 2022 Category: Endocrinology Source Type: research
PIEZO1 mechanoreceptor activation reduces adipogenesis in perivascular adipose tissue preadipocytes
In this study, we hypothesize that activation of PIEZO1 reduces adipogenesis in PVAT preadipocytes. The hypothesis was tested using pharmacological and mechanical activation of PIEZO1. Thoracic aorta PVAT (APVAT) was collected from 10-wk old male SD rats (n=15) to harvest preadipocytes that were differentiated to adipocytes in the presence of the PIEZO1 agonist Yoda1 (10 µM). Mechanical stretch was applied with the FlexCell System at 12% elongation, half-sine at 1 Hz simultaneously during the 4 d of adipogenesis (MS+, mechanical force applied; MS-, no mechanical force used). Yoda1 reduced adipogenesis by 33% compared wi...
Source: Frontiers in Endocrinology - August 31, 2022 Category: Endocrinology Source Type: research
Functions of Membrane Progesterone Receptors (mPRs, PAQRs) in Nonreproductive Tissues
Endocrinology. 2022 Aug 30:bqac147. doi: 10.1210/endocr/bqac147. Online ahead of print.ABSTRACTGender differences in a wide variety of physiological parameters have implicated the ovarian hormones, estrogens and progesterone, in the regulation of numerous nonreproductive tissue functions. Rapid, nongenomic (nonclassical) progesterone actions mediated by membrane progesterone receptors (mPRs), which belong to the progestin and AdipoQ receptor (PAQR) family, have been extensively investigated in reproductive and nonreproductive tissues since their discovery in fish ovaries 20 years ago. The five mPR subtypes (α, β, γ, δ,...
Source: Endocrinology - August 30, 2022 Category: Endocrinology Authors: Peter Thomas Yefei Pang Maria Andrea Camilletti Luca F Castelnovo Source Type: research
MARK2 and MARK4 regulate Sertoli cell BTB dynamics through microtubule and actin cytoskeletons
Endocrinology. 2022 Aug 12:bqac130. doi: 10.1210/endocr/bqac130. Online ahead of print.ABSTRACTMARKs (microtubule affinity-regulating kinases) are non-receptor Ser/Thr protein kinases known to regulate cell polarity and microtubule dynamics in C. elegans, Drosophila, invertebrates, vertebrates and mammals. An earlier study has shown that MARK4 is present at the ectoplasmic specialization (EC) and blood-testis barrier (BTB) in the seminiferous epithelium of adult rat testes. Here, we report the function of MARK4 and another isoform MARK2 in Sertoli cells at the BTB. Knockdown of MARK2, MARK4 or MARK2 and MARK4 by RNAi using...
Source: Endocrinology - August 16, 2022 Category: Endocrinology Authors: Elizabeth I Tang C Yan Cheng Source Type: research
MicroRNA-574 Impacts Granulosa Cell Estradiol Production via Targeting TIMP3 and ERK1/2 Signaling Pathway
Estradiol represents a key steroid ovarian hormone that not only plays a vital role in ovarian follicular development but also is associated with many other reproductive functions. Our primary study revealed that miR-574 expression decreased in porcine granulosa cells during development from small to large follicles, and the increase of ERK1/2 phosphorylation accompanies this change. Since it has been well established that the ERK1/2 activity is tightly associated with granulosa cell functions, including ovarian hormone production, we thus further investigate if the miRNA is involved in the regulation of estradiol product...
Source: Frontiers in Endocrinology - June 23, 2022 Category: Endocrinology Source Type: research
Insight Into Mouse Models of Hyperthyroidism
Hyperthyroidism is characterized by an increase in the synthesis and secretion of thyroid hormones in the thyroid gland, and the most common cause of overproduction of thyroid hormones is Graves’ disease (GD). Long-term disease models of hyperthyroidism have been established. In general, methods to induce GD include transfection of fibroblasts, injecting plasmids or adenovirus containing thyroid stimulating hormone receptor (TSHR) or TSHR subunit, and exogenous artificial thyroid hormone supplementation. Fortunately, in mouse studies, novel treatments for GD and Graves’ orbitopathy (GO) were discovered. It has been rep...
Source: Frontiers in Endocrinology - June 22, 2022 Category: Endocrinology Source Type: research
IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes
CONCLUSIONS: The results of this study suggest that auto/paracrine IGF-1 contributes to Akt and ERK phosphorylation in chicken myotubes.PMID:35717687 | DOI:10.1016/j.ghir.2022.101478
Source: Growth Hormone and IGF Research - June 19, 2022 Category: Endocrinology Authors: Takaoki Saneyasu Tomonori Nakamura Kazuhisa Honda Hiroshi Kamisoyama Source Type: research
