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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes
CONCLUSIONS: The results of this study suggest that auto/paracrine IGF-1 contributes to Akt and ERK phosphorylation in chicken myotubes.PMID:35717687 | DOI:10.1016/j.ghir.2022.101478
Source: Growth Hormone and IGF Research - June 19, 2022 Category: Endocrinology Authors: Takaoki Saneyasu Tomonori Nakamura Kazuhisa Honda Hiroshi Kamisoyama Source Type: research
Thyroid hormone transporters in a human placental cell model
Conclusions Using pharmacological inhibitors, we show that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears independent of known TH transporters, suggesting the presence of, currently unknown, alternative transporter(s).PMID:35699060 | DOI:10.1089/thy.2021.0503
Source: Thyroid : official journal of the American Thyroid Association - June 14, 2022 Category: Endocrinology Authors: Zhongli Chen A S Elise van der Sman Stefan Groeneweg Linda J de Rooij W Edward Visser Robin P Peeters Marcel E Meima Source Type: research
DOCK4 regulates ghrelin production in gastric X/A-like cells
ConclusionsOur results identify DOCK4 as a critical regulator for ghrelin production in gastric X/A-like cells.
Source: Journal of Endocrinological Investigation - June 11, 2022 Category: Endocrinology Source Type: research
Repurposed major urinary protein pheromones and adult sensory neurons: Roles in neuron plasticity and experimental diabetes
Am J Physiol Endocrinol Metab. 2022 May 30. doi: 10.1152/ajpendo.00001.2022. Online ahead of print.ABSTRACTMajor urinary proteins (MUPs), members of the broader lipocalin protein family, are classified as pheromones that are excreted in male rodent urine to define conspecific territoriality. In screening for differentially regulated mRNA transcripts in a mouse model of type 1 experimental diabetes mellitus (DM), we identified an unexpected upregulation of several closely related MUP transcripts within diabetic sensory dorsal root ganglia (DRGs). Both sexes expressed overall MUP protein content as identified by an antibody ...
Source: Am J Physiol Endocri... - May 31, 2022 Category: Endocrinology Authors: Trevor Poitras Vandana Singh Ramanaguru Piragasam Xiuling Wang Atef Mahmoud Mannaa Ambika Chandrasekhar Jose Martinez Richard Fahlman Douglas W Zochodne Source Type: research
Therapeutic Potential of Targeting Periostin in the Treatment of Graves ’ Orbitopathy
In this study we investigate periostin in the pathogenesis of Graves’ orbitopathy (GO) using human orbital adipose tissue obtained from surgery and primary cultured orbital fibroblasts in vitro. POSTN (gene encoding periostin) expression in Graves’ orbital tissues and healthy control tissues was studied, and the role of periostin in GO pathologic mechanism was examined through small-interfering RNA (siRNA)-mediated silencing. POSTN gene expression was significantly higher in Graves’ orbital tissues than healthy control tissues in real-time PCR results, and immunohistochemical staining revealed higher expression of pe...
Source: Frontiers in Endocrinology - May 30, 2022 Category: Endocrinology Source Type: research
Role of the Ubiquitin Ligase RNF149 in the Development of Rat Neonatal Gonocytes
Male reproductive function depends on the formation of spermatogonial stem cells from their neonatal precursors, the gonocytes. Previously, we identified several UPS enzymes dynamically altered during gonocyte differentiation. The present work focuses on understanding the role of the RING finger protein 149 (RNF149), an E3 ligase that we found to be strongly expressed in gonocytes and downregulated in spermatogonia. The quantification of RNF149 mRNA from postnatal day (PND) 2 to 35 (puberty) in rat testis, brain, liver, kidney, and heart indicated that its highest levels are found in the testis. RNF149 knock-down in PND3 r...
Source: Frontiers in Endocrinology - May 13, 2022 Category: Endocrinology Source Type: research
Quantitative Ubiquitinomics Revealed Abnormal Ubiquitinated ATP7A Involved in Down-Regulation of ACTH in Silent Corticotroph Adenomas
Ubiquitination is reported to be a critical biological event on ACTH secretion in corticotroph adenomas. However, the effect of ubiquitylation on ACTH secretion in silent corticotroph adenomas (SCAs) remains unclear. The aim of our study was to explore the mechanism of decreased secretion of ACTH in SCAs with ubiquitinomics. The differently expressed ubiquitinated proteins between SCAs and functioning corticotroph adenomas (FCAs) were identified by 4D label-free mass spectrometer, followed by bioinformatics analysis. The function of the candidate ubiquitinated protein ATP7A (K333) was validated in AtT20 cells. A total of 1...
Source: Frontiers in Endocrinology - May 11, 2022 Category: Endocrinology Source Type: research
