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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
Inhibition of miR-29 activity in the myeloid lineage increases response to calcitonin and trabecular bone volume in mice
Endocrinology. 2021 Jun 30:bqab135. doi: 10.1210/endocr/bqab135. Online ahead of print.ABSTRACTThe miR-29-3p family (miR-29a, miR-29b, miR-29c) of microRNAs is increased during RANKL-induced osteoclastogenesis. In vivo, activation of a miR-29-3p tough decoy inhibitor (TuD) in LysM-cre expressing cells (myeloid lineage) resulted in mice displaying enhanced trabecular and cortical bone volume, due to decreased bone resorption. Calcitonin receptor (Calcr) is a miR-29 target that negatively regulates bone resorption. CALCR was significantly increased in RANKL-treated miR-29-decoy osteoclasts, and these cells were more responsi...
Source: Endocrinology - June 30, 2021 Category: Endocrinology Authors: Bongjin Shin Henry C Hrdlicka Anne M Delany Sun-Kyeong Lee Source Type: research
Roles of NR5A1 and NR5A2 in the regulation of steroidogenesis by Clock gene and bone morphogenetic proteins by human granulosa cells
Endocr J. 2021 Jun 26. doi: 10.1507/endocrj.EJ21-0223. Online ahead of print.ABSTRACTThe functional role of the transcription factors NR5A1 and NR5A2 and their interaction with Clock gene and bone morphogenetic proteins (BMPs) were investigated in human granulosa KGN cells. Treatment with BMP-15 and GDF-9 suppressed forskolin (FSK)-induced steroidogenesis as shown by the mRNA expression levels of StAR and P450scc but not the mRNA expression level of P450arom. Of interest, treatment with BMP-15 and GDF-9 also suppressed FSK-induced NR5A2 mRNA expression. Treatment with BMP-15 suppressed NR5A2 mRNA and protein expression but...
Source: Endocrine Journal - June 28, 2021 Category: Endocrinology Authors: Atsuhito Suyama Nahoko Iwata Yoshiaki Soejima Yasuhiro Nakano Koichiro Yamamoto Takahiro Nada Fumio Otsuka Source Type: research
The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes
CONCLUSIONS: IGF-I and leucine cooperatively increased mTORC1 activity in C2C12 cells. IGF-I increased Sestrin2. Sestrin2 siRNA experiments showed that Sestrin2 was involved in the effect of leucine and IGF-I on mTORC1 activity in C2C12 and L6 cells, and suggested that increased Sestrin2 by IGF-I pretreatment might play a role in enhancing the effect of leucine on mTORC1.PMID:34126555 | DOI:10.1016/j.ghir.2021.101406
Source: Growth Hormone and IGF Research - June 14, 2021 Category: Endocrinology Authors: Ran Sawa Ikumi Wake Yu Yamamoto Yasuhiko Okimura Source Type: research
