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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4 α induction
Am J Physiol Endocrinol Metab. 2022 May 2. doi: 10.1152/ajpendo.00163.2021. Online ahead of print.ABSTRACTSelenoprotein P (SeP; encoded by SELENOP in humans, Selenop in rodents) is a hepatokine that is upregulated in the liver of humans with type 2 diabetes. Excess SeP contributes to the onset of insulin resistance and various type 2 diabetes-related complications. We have previously reported that the long-chain saturated fatty acid, palmitic acid, upregulates Selenop expression, whereas the polyunsaturated fatty acids (PUFAs) downregulate it in hepatocytes. However, the effect of medium-chain fatty acids (MCFAs) on Seleno...
Source: Am J Physiol Endocri... - May 2, 2022 Category: Endocrinology Authors: Kyoko Kamoshita Hirohiko Tsugane Kiyo-Aki Ishii Hiroaki Takayama Xingyu Yao Halimulati Abuduwaili Ryota Tanida Yasumasa Taniguchi Hein Ko Oo Guzel Gafiyatullina Shuichi Kaneko Seiichi Matsugo Toshinari Takamura Source Type: research
Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes
Endocr J. 2022 Mar 23. doi: 10.1507/endocrj.EJ21-0392. Online ahead of print.ABSTRACTSelenoprotein P is upregulated in type 2 diabetes, causing insulin and exercise resistance. We have previously reported that eicosapentaenoic acid (EPA) negatively regulates Selenop expression by suppressing Srebf1 in H4IIEC3 hepatocytes. However, EPA downregulated Srebf1 long before downregulating Selenop. Here, we report additional novel mechanisms for the Selenop gene regulation by EPA. EPA upregulated Foxo1 mRNA expression, which was canceled with the ERK1/2 inhibitor, but not with the PKA inhibitor. Foxo1 knockdown by siRNA initiated ...
Source: Endocrine Journal - March 24, 2022 Category: Endocrinology Authors: Kyoko Kamoshita Natsumi Tajima-Shirasaki Kiyo-Aki Ishii Takayoshi Shirasaki Hiroaki Takayama Halimulati Abuduwaili Tuerdiguli Abuduyimiti Hein Ko Oo Xingyu Yao Qifang Li Cynthia M Galicia-Medina Shuichi Kaneko Toshinari Takamura Source Type: research
Liver and muscle-specific effects of phoenixin-20 on the insulin-like growth factor system mRNAs in zebrafish
CONCLUSIONS: Collectively, this research shows that Pnx-20 is a tissue-specific regulator of the liver (suppressor) and muscle (stimulant) Igf signaling in both male and female zebrafish.PMID:35305530 | DOI:10.1016/j.ghir.2022.101456
Source: Growth Hormone and IGF Research - March 19, 2022 Category: Endocrinology Authors: Jithine Jayakumar Rajeswari Emilio J V élez Suraj Unniappan Source Type: research
