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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
Characterization of chinese tongue sole (Cynoglossus semilaevis) 24-dehydrocholesterol reductase: Expression profile, epigenetic modification, and its knock-down effect
Gen Comp Endocrinol. 2021 Jul 26:113870. doi: 10.1016/j.ygcen.2021.113870. Online ahead of print.ABSTRACTThe sexual size dimorphism of the Chinese tongue sole (Cynoglossus semilaevis) has greatly obstructed its sustainable development; however, the underlying mechanism remains unclear. Based on C. semilaevis transcriptomic information, 24-dehydrocholesterol reductase (dhcr24) was identified in steroid biosynthesis, showing female-liver-biased expression. Dhcr24 has been reported to participate in various processes, such as cholesterol synthesis, oxidative stress response, neuroprotection, and cell survival. The present stu...
Source: General and Comparative Endocrinology - July 29, 2021 Category: Endocrinology Authors: Na Wang Zhihong Gong Jialin Wang Wenteng Xu Qian Yang Songlin Chen Source Type: research
CREB3 Transactivates lncRNA ZFAS1 to Promote Papillary Thyroid Carcinoma Metastasis by Modulating miR-373-3 < em > p < /em > /MMP3 Regulatory Axis
In conclusion, CREB3 activated lncRNA ZFAS1 at the transcriptional level to promote PTC metastasis by modulating miR-373-3p/MMP3.PMID:34249125 | PMC:PMC8238556 | DOI:10.1155/2021/9981683
Source: International Journal of Endocrinology - July 12, 2021 Category: Endocrinology Authors: Gang Wang Yuan Le Liping Wei Lian Cheng Source Type: research
G Protein-Coupled Estrogen Receptor 1 (GPER1) Mediates Aldosterone-Induced Endothelial Inflammation in a Mineralocorticoid Receptor-Independent Manner
CONCLUSION: These findings not only demonstrated the role of GPER1 in aldosterone-induced vascular inflammation but also suggested an alternative for pharmaceutical treatment of hyperaldosteronism considering the unsatisfying effect on cardiovascular risks with MR antagonists.PMID:34239558 | PMC:PMC8235990 | DOI:10.1155/2021/5575927
Source: International Journal of Endocrinology - July 9, 2021 Category: Endocrinology Authors: Ziwei Tang Qifu Li Qingfeng Cheng Mei Mei Ying Song Zhipeng Du Wenwen He Jinbo Hu Shumin Yang Zhihong Wang Source Type: research
Histone Deacetylase 4 Controls Extracellular Matrix Production in Orbital Fibroblasts from Graves' Ophthalmopathy Patients
CONCLUSION: Our data indicated for the first time that altered HDAC4 regulation along with H3K9 hypoacetylation might represent a mechanism that contributes to excessive proliferation and extracellular matrix production by orbital fibroblasts in GO. HDAC4 might represent a novel target for GO therapy.PMID:34235979 | DOI:10.1089/thy.2020.0948
Source: Thyroid : official journal of the American Thyroid Association - July 8, 2021 Category: Endocrinology Authors: Supanuch Ekronarongchai Tanapat Palaga Preamjit Saonanon Vannakorn Pruksakorn Nattiya Hirankarn P Martin van Hagen Willem A Dik Sita Virakul Source Type: research
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling
Conclusions/interpretationIn summary, our study identifies HAND2 as a novel obesity-linked adipocyte transcription factor, highlighting new mechanisms of GR-dependent adipogenesis in humans and mice.Data availabilityArray data have been submitted to the GEO database at NCBI (GSE148699).Graphical abstract
Source: Diabetologia - June 30, 2021 Category: Endocrinology Source Type: research
Inhibition of miR-29 activity in the myeloid lineage increases response to calcitonin and trabecular bone volume in mice
Endocrinology. 2021 Jun 30:bqab135. doi: 10.1210/endocr/bqab135. Online ahead of print.ABSTRACTThe miR-29-3p family (miR-29a, miR-29b, miR-29c) of microRNAs is increased during RANKL-induced osteoclastogenesis. In vivo, activation of a miR-29-3p tough decoy inhibitor (TuD) in LysM-cre expressing cells (myeloid lineage) resulted in mice displaying enhanced trabecular and cortical bone volume, due to decreased bone resorption. Calcitonin receptor (Calcr) is a miR-29 target that negatively regulates bone resorption. CALCR was significantly increased in RANKL-treated miR-29-decoy osteoclasts, and these cells were more responsi...
Source: Endocrinology - June 30, 2021 Category: Endocrinology Authors: Bongjin Shin Henry C Hrdlicka Anne M Delany Sun-Kyeong Lee Source Type: research
