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Specialty: Endocrinology

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Total 648 results found since Jan 2013.

Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes
CONCLUSION: These results suggest that the SENP2-PPARα pathway plays an important role in leptin-induced FAO in white adipocytes.PMID:36872063 | DOI:10.4093/dmj.2022.0156
Source: Diabetes and Metabolism Journal - March 5, 2023 Category: Endocrinology Authors: Praise Chanmee Kim Ji Seon Lee Sung Soo Chung Kyong Soo Park Source Type: research

A large-scale screening and functional sorting of tumour microenvironment prognostic genes for breast cancer patients
ConclusionsThis integrated study hypothesised an innovative TME-associated genetic functional network for breast cancer patients. The external relationships between these TME prognostic genes and the disease were measured. Meanwhile, the internal molecular mechanisms were also investigated.
Source: Frontiers in Endocrinology - March 1, 2023 Category: Endocrinology Source Type: research

5-Iodotubercidin Inhibits the Growth of Insulinoma Cells by Inducing Apoptosis
Conclusions: 5-iodotubercidin induce DNA damage leading to insulinoma cells apoptosis by activating ATM/p53 pathway. Therefore, this is a potential strategy for treating Insulinoma.
Source: Neuroendocrinology - February 9, 2023 Category: Endocrinology Source Type: research

BASP1 promotes high glucose ‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway.
Source: Journal of Diabetes Investigation - February 9, 2023 Category: Endocrinology Authors: Fengnan Sun, Junwei Liu, Yanzheng Wang, Hongmei Yang, Danfeng Song, Haiyan Fu, Xingxing Feng Tags: Original Article Source Type: research

Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling
In this study, we investigated whether AGEs could exacerbate skeletal muscle atrophy and its related insulin resistance. Mice were exposed to AGEs. Forkhead box O1 (FOXO1) was silenced by a constructed viral vector carrying siRNA. Skeletal muscle atrophy was evaluated by H&E, oil red O, myosin skeletal heavy chain (MHC) and laminin immunofluorescent stains. Reactive oxygen species (ROS) generation was assessed by DHE stain. Western blotting was used to evaluate protein expression and phosphorylation. Insulin resistance was monitored by insulin tolerance test (ITT) and glucose infusion rate (GIR). Mice exposed to AGEs s...
Source: Am J Physiol Endocri... - February 1, 2023 Category: Endocrinology Authors: Haixia Du Yanpeng Ma Xiqiang Wang Yong Zhang Ling Zhu Shuang Shi Shuo Pan Zhongwei Liu Source Type: research