Targeting tumor hypoxia inhibits aggressive phenotype of dedifferentiated thyroid cancer

CONCLUSIONS: Hypoxia score serves as a significant indicator for dedifferentiation status, prognoses and immunotherapeutic response predicted by Tumor Immune Dysfunction and Exclusion in DDTC patients. Targeting hypoxia by ACF is useful to alleviate aggressive phenotype of ATC in pre-clinical model of DDTC.PMID:36190930 | DOI:10.1210/clinem/dgac548

Source: The Journal of Clinical Endocrinology and Metabolism - October 3, 2022 Category: Endocrinology Authors: Ben Ma Shishuai Wen Yi Luo Tingting Zhang Yichen Yang Cenkai Shen Yan Zhang Qinghai Ji Ning Qu Yu Wang Source Type: research