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Total 572 results found since Jan 2013.

Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis
Conclusions: HSP90 appears to play crucial roles in hepatobiliary transformation during sea lamprey metamorphosis. Sea lamprey is a useful animal model to study postembryonic development and mechanisms for hsp90-induced hepatobiliary transformation.
Source: BMC Developmental Biology - December 1, 2015 Category: Zoology Authors: Yu-Wen Chung-DavidsonChu-Yin YehUgo BussyKe LiPeter DavidsonKaben NanlohyC. BrownSteven WhyardWeiming Li Source Type: research

The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells.
CONCLUSIONS: Simvastatin restored the expression of BIM to induce apoptotic cell death in NSCLC cells harboring an EGFR-resistant mutation. Our study suggests the potential utility of simvastatin as a BIM-targeted treatment for NSCLC. PMID: 26756263 [PubMed - in process]
Source: Experimental Lung Research - February 18, 2016 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research

Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/NF-кB/ZNF202 pathway in THP-1 macrophages.
Abstract Macrophage-activating lipopeptide-2 (MALP-2) has been shown to promote the development of atherosclerosis. ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein, plays a critical role in mediating cholesterol export from macrophages to apolipoprotein A-I (apoA-I). However, whether MALP-2 can regulate the expression of ABCA1 is still largely unknown. The aim of this study was to explore the effects of MALP-2 on ABCA1 expression in THP-1 macrophages and the underlying mechanisms. Our results showed that the treatment of cells with MALP-2 decreased ABCA1 level and suppressed cholesterol efflux...
Source: Acta Biochimica et Biophysica Sinica - February 27, 2016 Category: Biochemistry Authors: Peng L, Zhang Z, Zhang M, Yu X, Yao F, Tan Y, Liu D, Gong D, Chong H, Liu X, Zheng X, Tian G, Tang C Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling.
CONCLUSIONS: Reductions in Dio1 expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone response element-independent manner. PMID: 27150392 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 4, 2016 Category: Cardiology Authors: Liu J, Hernandez-Ono A, Graham MJ, Galton VA, Ginsberg HN Tags: Arterioscler Thromb Vasc Biol Source Type: research

The anti ‑dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression.
The anti‑dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression. Mol Med Rep. 2016 Jul 13; Authors: Bryan-Marrugo OL, Arellanos-Soto D, Rojas-Martinez A, Barrera-Saldaña H, Ramos-Jimenez J, Vidaltamayo R, Rivas-Estilla AM Abstract Dengue virus (DENV) susceptibility to cholesterol depleting treatments has been previously reported. There are numerous questions regarding how DENV seizes cellular machinery and cholesterol to improve viral production and the effect of cholesterol sequestering agents on the cellular antiviral response. The aim of...
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells
In conclusion, Nrf2 plays a significant role in the down-regulation of CYP7A1 induced by AA in HepG2 cells.Abbreviations: AA, arachidonic acid; CYP7A1, cholesterol 7α-hydroxylase; FA, fatty acid; HFD, high-fat diet; NAFLD, non-alcoholic fatty liver disease; Nrf2, nuclear factor erythroid-derived 2-like 2; siRNA, small interfering RNA.
Source: Environmental Toxicology and Pharmacology - March 7, 2017 Category: Environmental Health Source Type: research

Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through ...
Conclusion Combined treatment with sulindac and simvastatin augmented their apoptotic potential in lung cancer cells through AKT signaling-dependent downregulation of survivin. These results indicate that sulindac and simvastatin may be clinically promising therapies for the prevention of lung cancer.
Source: Cancer Research and Treatment - October 26, 2014 Category: Cancer & Oncology Tags: Original Article Source Type: research

ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
Conclusions AT E2F1 –ASK1 molecularly defines a metabolically-detrimental obese sub-phenotype. Functionally, it may negatively affect AT endocrine function, linking AT stress to whole-body metabolic dysfunction.
Source: Molecular Metabolism - May 7, 2017 Category: Endocrinology Source Type: research

Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1
Publication date: August 2017 Source:Pharmacological Research, Volume 122 Author(s): Nicola Ferri, Silvia Marchianò, Maria Giovanna Lupo, Annalisa Trenti, Giuseppe Biondo, Paola Castaldello, Alberto Corsini Statins are known to increase the plasma levels of proprotein convertase subtilisin kexin type 9 (PCSK9) through the activation of the sterol responsive element binding protein (SREBP) pathway due to the inhibition of cholesterol biosynthesis. In the present study, we explore a possible role of the prenylated proteins on the statin-mediated PCSK9 induction in Caco-2 cells. Simvastatin (40μM) induced both PCSK9 mRNA (...
Source: Pharmacological Research - June 10, 2017 Category: Drugs & Pharmacology Source Type: research

Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients
This study aimed to determine the expression of hepatic ABCA1 levels in a cholestatic rat model and patients with primary biliary cholangitis (PBC). A cholesterol efflux study was conducted withAbca1 knock down using siRNA in WIF9 cells. Cholesterol levels in the ABCA1 siRNA cells in the medium were significantly decreased compared with those in controls (P <  0.05). Hepatic ABCA1 mRNA levels were significantly higher in BDL rats than in control rats (P <  0.05). Furthermore, the protein expression level of hepatic ABCA1 was also significantly increased by 200% in BDL rats (P <  0.05). In PBC patients, expre...
Source: Medical Molecular Morphology - June 28, 2017 Category: Molecular Biology Source Type: research

Composite liposome-PEI/nucleic acid lipopolyplexes for safe and efficient gene delivery and gene knockdown
Publication date: 1 October 2017 Source:Colloids and Surfaces B: Biointerfaces, Volume 158 Author(s): Shashank Reddy Pinnapireddy, Lili Duse, Boris Strehlow, Jens Schäfer, Udo Bakowsky Cytotoxicity is a major drawback impeding the therapeutic use of gene delivery and gene down-regulation vehicles. Apart from cytotoxicity, rapid degradation and low cellular uptake are other major factors affecting therapeutic use. Considering the above factors, formulation and development of PEI (Polyethylenimine) based, liposome encapsulated delivery vehicles with improved transfection efficiency and low cytotoxicity which can be used fo...
Source: Colloids and Surfaces B: Biointerfaces - July 4, 2017 Category: Biochemistry Source Type: research

Apolipoprotein E promotes invasion in oral squamous cell carcinoma.
Abstract Oral squamous cell carcinoma (OSCC) patients generally have a poor prognosis, due to the invasive nature of these tumors. In comparing transcription profiles between OSCC tumors with a more invasive (WPOI 5) versus a less invasive (WPOI 3) pattern of invasion, we identified a total of 97 genes that were overexpressed at least 1.5-fold in the more invasive tumor subtype. The most functionally relevant genes were assessed using in vitro invasion assays with an OSCC cell line (UM-SCC-1). Individual siRNA knockdown of 15 of these 45 genes resulted in significant reductions in tumor cell invasion compared to a...
Source: Am J Pathol - July 24, 2017 Category: Pathology Authors: Jayakar SK, Loudig O, Brandwein-Gensler M, Kim RS, Ow TJ, Ustun B, Harris TM, Prystowsky MB, Childs G, Segall JE, Belbin TJ Tags: Am J Pathol Source Type: research

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppar γ/Lxrα Signaling Pathway-Dependent Manner
Conclusions: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPAR γ/LXRα signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS.Cell Physiol Biochem 2017;43:1703 –1717
Source: Cellular Physiology and Biochemistry - October 18, 2017 Category: Cytology Source Type: research

Failure of active targeting by a cholesterol-anchored ligand and improvement by altering the lipid composition to prevent ligand desorption
Publication date: 30 January 2018 Source:International Journal of Pharmaceutics, Volume 536, Issue 1 Author(s): Shoshiro Yamamoto, Yu Sakurai, Hideyoshi Harashima Although anti-angiogenic therapy is predicted to be an effective therapy for treating cancer, selectively targeting tumor endothelial cells (TECs), and not normal endothelial cells, remains a major obstacle. Modifying a drug carrier with a targeting ligand is a popular strategy for developing an active-targeting type drug delivery system (DDS). We previously reported that a cyclo(Arg-Gly-Asp-D-Phe-Lys) (cRGD)-equipped liposome that contains encapsulated siRNA (R...
Source: International Journal of Pharmaceutics - November 28, 2017 Category: Drugs & Pharmacology Source Type: research