Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppar γ/Lxrα Signaling Pathway-Dependent Manner

Conclusions: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPAR γ/LXRα signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS.Cell Physiol Biochem 2017;43:1703 –1717
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research