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Condition: Cholesterol

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Total 572 results found since Jan 2013.

Molecules, Vol. 25, Pages 1877: Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity
ernolovskaya Cholesterol derivatives of nuclease-resistant, anti-MDR1 small-interfering RNAs were designed to contain a 2’-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order to investigate their accumulation and silencing activity in vitro and in vivo. The results showed that increasing the length of the RNA duplex in such a conjugate increases its biological activity when delivered using a transfection agent. However, the efficiency of accumulation in human drug-resistant KB-8-5 cells during delivery in vitro in a carrier-free mode was reduced as well as efficiency of target gene silencing. TsiRNAs dem...
Source: Molecules - April 17, 2020 Category: Chemistry Authors: Ivan V. Chernikov Daniil V. Gladkikh Ulyana A. Karelina Mariya I. Meschaninova Alya G. Ven ’yaminova Valentin V. Vlassov Elena L. Chernolovskaya Tags: Article Source Type: research

PCSK9 Inhibition and Atherosclerosis: Current Therapeutic Option and Prospection.
Abstract Low-density lipoprotein cholesterol (LDL-C) is a pivotal factor in atherosclerotic cardiovascular disease (ASCVD), the leading cause of worldwide mortality. The limitations of statin therapy require alternative treatment strategies to achieve target LDL-C level. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LDLR recycling, consequently regulating plasma cholesterol levels. Monoclonal antibodies targeting PCSK9 increased expression of LDLRs at the cell surface and therefore decreased circulating LDL-C. PCSK9 inhibitors have shown great efficacy in reducing plasma LDL-C le...
Source: Mol Biol Cell - July 28, 2020 Category: Molecular Biology Authors: Pandey P, Zhao C, Liu B Tags: Methods Mol Biol Source Type: research

IGF-1 affects the development of myocarditis in LDL-R knockout mice by inhibiting peritoneal infiltration of macrophages.
CONCLUSIONS: IGF-1 expression is increased in myocarditis. The downregulation of IGF-1 expression inhibits macrophages infiltration, reduces the expression of MIF and inflammatory factors, and improves myocarditis injury. PMID: 32767338 [PubMed - in process]
Source: Methods of Information in Medicine - July 31, 2020 Category: Information Technology Authors: Li HD, Chen B, Yang F Tags: Eur Rev Med Pharmacol Sci Source Type: research

A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis.
In this study, MIN6 cells were treated with oxidized low-density lipoprotein (ox-LDL) for 24 h, and then intracellular lipid droplets and cell apoptosis were quantified, and SCGN and ER stress markers were identified by western blot analysis. Furthermore, small interfer RNA (siRNA)-mediated SCGN knockdown and recombinant plasmid-mediated SCGN restoration experiments were performed to confirm the role of SCGN in ER stress and associated cell apoptosis. Finally, the interaction of SCGN with ATF4 was computationally predicted and then validated by a co-immunoprecipitation assay. We found that ox-LDL treatment increased the le...
Source: Acta Biochimica et Biophysica Sinica - December 8, 2020 Category: Biochemistry Authors: Wu L, Lv Y, Lv Y, Xiang S, Zhao Z, Tang Z, Ou L, Yan B, Xiao X, Wen G, Cao R, Yang J Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

GSE167197 Peroxisome import stress induces eIF2 α phosphorylation and impairs ribosome biogenesis
Contributors : Kerui Huang ; Jinoh Kim ; Pham Vo ; Ting Miao ; Mirre J Simons ; Hua BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogaster ; Homo sapiensPeroxisome biogenesis diseases (PBDs) are characterized by global defects in peroxisomal function and can result in severe brain, liver, kidney, and bone malfunctions. PBDs are due to mutations in peroxisome biogenesis factors (PEX genes) that are responsible for peroxisome assembly and function. Increasing evidence suggests that peroxisome import functions decline during aging. However, the transcriptome profiling of peroxiso...
Source: GEO: Gene Expression Omnibus - February 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Homo sapiens Source Type: research

A Critical Review of the Efficacy and Safety of Inclisiran
AbstractThe association between low-density cholesterol (LDL-C) and cardiovascular disease (CVD) is well-established, with an emphasis on lowering LDL-C levels to reduce cardiovascular events. Statin therapy has been the traditional treatment for LDL-C reduction, in addition to lifestyle modifications, but studies have shown that a substantial proportion of patients does not reach target LDL-C goals despite receiving maximally tolerated statin medications. Additionally, statin therapy is associated with a few shortcomings as many patients initiated on these medications discontinue treatment within 1 year because of lack of...
Source: American Journal of Cardiovascular Drugs - May 6, 2021 Category: Cardiology Source Type: research

Inhibition of angiopoietin-like 3 for the management of severe hypercholesterolemia
Purpose for review Despite the therapeutic advances for patients with severe hypercholesterolemia, particularly those with homozygous familial hypercholesterolemia (HoFH), most patients are unable to achieve target low-density lipoprotein cholesterol (LDL-C) levels with the current available standard lipid-lowering therapy (LLT). We review the role of angiopoietin-like 3 (ANGPTL3) inhibition as an additional therapeutic option for severe hypercholesterolemia, particularly HoFH. Recent findings Evinacumab is a monoclonal antibody against ANGPTL3, and reduces LDL-C independent of LDL-receptor activity. ANGPTL3 inh...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients
Conclusions: ABCA1/G1 was inhibited by the stimulation of ANP when combined with NPR-A through the PPAR-γ/LXRα pathway in THP-1 macrophages. The ABCA1/G1-mediated cholesterol efflux was also impaired by the stimulation of ANP. This may provide a new explanation for the decreased level of HDL-C in HDP patients.
Source: Frontiers in Pharmacology - July 28, 2021 Category: Drugs & Pharmacology Source Type: research

Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq
ConclusionsThe 3 differentially expressed circRNAs may play an important role in the process of AST promoting cholesterol efflux and may be used as biomarkers to prevent AS.
Source: Genes and Nutrition - August 28, 2021 Category: Nutrition Source Type: research

Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Autophagy. 2021 Sep 15:1-19. doi: 10.1080/15548627.2021.1965421. Online ahead of print.ABSTRACTEpidemiological and clinical studies have shown that exposure to particulate matter (PM) is associated with an increased incidence of lung cancer and metastasis. However, the underlying mechanism remains unclear. Here, we demonstrated the central role of PM-induced neutrophil recruitment in promoting lung cancer metastasis. We found that reactive oxygen species (ROS)-mediated alveolar epithelial macroautophagy/autophagy was essential for initiating neutrophil chemotaxis and pre-metastatic niche formation in the lungs in response ...
Source: Autophagy - September 15, 2021 Category: Cytology Authors: Jiajun Liu Shumin Li Xuefeng Fei Xi Nan Yingying Shen Huiqing Xiu Stephania A Cormier Chaojie Lu Chuqi Guo Shibo Wang Zhijian Cai Pingli Wang Source Type: research

Effects of allyl isothiocyanate on the expression, function, and its mechanism of ABCA1 and ABCG1 in pulmonary of COPD rats
CONCLUSION: These results suggest that AITC improves COPD by promoting RCT process and reducing inflammatory response via activating LXR pathways.PMID:34802946 | DOI:10.1016/j.intimp.2021.108373
Source: International Immunopharmacology - November 22, 2021 Category: Allergy & Immunology Authors: Wen-Tao Zhu Chen-Hui Li Ting-Ting Dai Fu-Lin Tao Meng-Wen Wang Chong-Yang Wang Zhi-Li Han Nian-Xia Sun Ya-Nan Zhao Dian-Lei Wang Source Type: research

Inclisiran (Leqvio) for LDL-Cholesterol Lowering
Date: March 21, 2022 Issue #:  1646Summary:  The FDA has approved inclisiran (Leqvio– Novartis), a small interfering RNA (siRNA) directed to proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA, as an adjunct to diet and maximally tolerated statin therapy for subcutaneous (SC) treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atheroscler otic cardiovascular disease (ASCVD) who require additional lowering of low-density lipoprotein cholesterol (LDL-C). Inclisiran is the first FDA-approved PCSK9-directed siRNA therapeutic agent.
Source: The Medical Letter - February 8, 2022 Category: Drugs & Pharmacology Authors: admin Tags: alirocumab bempedoic acid evolocumab Ezetimibe Ezetrol Hypercholesterolemia inclisiran Leqvio Nexletol Nexlizet Praluent Repatha Statins Zetia Source Type: research