Updates on genetics and molecular biology
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

Ketogenic therapies in mild cognitive impairment and dementia
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

From unbiased transcriptomics to understanding the molecular basis of atherosclerosis
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

Update on proprotein convertase subtilisin/kexin type 9 inhibitors, lipoprotein(a) and cardiovascular risk
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

HDL and persistent inflammation immunosuppression and catabolism syndrome
This study reviews the mechanisms of HDL cholesterol immunomodulation in the context of the mechanisms of chronic inflammation and immunosuppression causing persistent inflammation, immunosuppression and catabolism syndrome (PICS) and describes potential therapies and gaps in current research. Recent findings Low HDL cholesterol is predictive of acute sepsis severity and outcome. Recent research has indicated apolipoprotein is a prognostic indicator of long-term outcomes. The pathobiologic mechanisms of PICS have been elucidated in the past several years. Recent research of the interaction of HDL pathways in related...
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

Lipids and cardiovascular calcification: contributions to plaque vulnerability
Purpose of review Cardiovascular calcification, a common feature of atherosclerotic lesions, has long been known to associate with cardiovascular risk. The roles of lipoproteins in atherosclerosis are also established, and lipid-modifying therapies have shown capacity for plaque regression. However, the association of lipid-modifying therapies with calcification is more complex, and currently no medical therapies have been found to reverse or attenuate calcification in patients. In this review, we summarize recent developments in our understanding of the interplay between lipids and cardiovascular calcification, as wel...
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

LDL receptor-related protein 1 and its interacting partners in tissue homeostasis
Purpose of review LDL receptor-related protein 1 (LRP1) is a multifunctional protein with endocytic and signal transduction properties due to its interaction with numerous extracellular ligands and intracellular proteins. This brief review highlights key developments in identifying novel functions of LRP1 in liver, lung, and the central nervous system in disease pathogenesis. Recent findings In hepatocytes, LRP1 complexes with phosphatidylinositol 4-phosphate 5-kinase-1 and its related protein to maintain intracellular levels of phosphatidylinositol (4,5) bisphosphate and preserve lysosome and mitochondria integ...
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

Metabolic regulation of macrophage proliferation and function in atherosclerosis
Purpose of review Macrophage accumulation within atherosclerotic plaque is a primary driver of disease progression. However, recent advances in both phenotypic and functional heterogeneity of these cells have allowed for improved insight into potential regulation of macrophage function within lesions. In this review, we will discuss recent insights on macrophage heterogeneity, lipid processing, metabolism, and proliferation in atherosclerosis. Furthermore, we will identify outstanding questions in the field that are pertinent to future studies. Recent findings With the recent development of single-cell RNA seque...
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

The iterative lipid impact on inflammation in atherosclerosis
Purpose of review Lipid-mediated atherogenesis is hallmarked by a chronic inflammatory state. Low-density lipoprotein cholesterol (LDL-C), triglyceride rich lipoproteins (TRLs), and lipoprotein(a) [Lp(a)] are causally related to atherosclerosis. Within the paradigm of endothelial activation and subendothelial lipid deposition, these lipoproteins induce numerous pro-inflammatory pathways. In this review, we will outline the effects of lipoproteins on systemic inflammatory pathways in atherosclerosis. Recent findings Apolipoprotein B-containing lipoproteins exert a variety of pro-inflammatory effects, ranging from...
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

Extracellular matrix: paving the way to the newest trends in atherosclerosis
Purpose of review The extracellular matrix (ECM) is critical for all aspects of vascular pathobiology. In vascular disease the balance of its structural components is shifted. In atherosclerotic plaques there is in fact a dynamic battle between stabilizing and proinflammatory responses. This review explores the most recent strides that have been made to detail the active role of the ECM – and its main binding partners – in driving atherosclerotic plaque development and destabilization. Recent findings Proteoglycans-glycosaminoglycans (PGs-GAGs) synthesis and remodelling, as well as elastin synthesis,...
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - September 8, 2021 Category: Lipidology Tags: EDITORIAL INTRODUCTIONS Source Type: research

Editorial: Discussing polygenic risk with lipid clinic patients
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: SPECIAL COMMENTARY Source Type: research

Evolving ANGPTL-based lipid-lowering strategies and beyond
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

Increasing fruits and vegetables to reduce mortality and promote independence
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

Cholesterol 25-hydroxylase expression following immune activation in response to SARS-CoV-2 infection
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

New insights in statins affecting atheromatous plaque macrophages
Purpose of review Macrophages are key protagonists of atherosclerotic plaque development and hence represent targets of therapeutic intervention. Statins are the most potent widely used atheroprotective drugs. Therefore, whether and how statins influence atheromatous plaque macrophages has remained at the center of cardiovascular research for decades. Recent findings Because statins are capable of regulating macrophage functions in cell culture, largely independent of their cholesterol-lowering effect, it was assumed that these pleiotropic effects operate in vivo as well. Recent experimental data, in line with c...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Lipids and peripheral neuropathy
Purpose of review Hyperlipidaemia is associated with the development of neuropathy. Indeed, a mechanistic link between altered lipid metabolism and peripheral nerve dysfunction has been demonstrated in a number of experimental and clinical studies. Furthermore, post hoc analyses of clinical trials of cholesterol and triglyceride-lowering pharmacotherapy have shown reduced rates of progression of diabetic neuropathy. Given, there are currently no FDA approved disease-modifying therapies for diabetic neuropathy, modulation of lipids may represent a key therapeutic target for the treatment of diabetic nerve damage. This r...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Genetic determinants of LDL cholesterol and risk of intracerebral haemorrhage
Purpose of review The role of lipids in spontaneous, nontraumatic intracerebral haemorrhage (ICH) remains controversial, as some studies suggest that lower levels of total and LDL cholesterol could increase the risk of this disease. Because of their random assortment during meiosis, genetic variants known to associate with lipid levels can be used as instruments to evaluate this relationship from a causal perspective. The purpose of this review is to summarize the existing literature related to genetically determined LDL cholesterol levels and risk of ICH. Recent findings A number of studies have demonstrated th...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

The impact of atherosclerotic cardiovascular disease, dyslipidaemia and lipid lowering therapy on Coronavirus disease 2019 outcomes: an examination of the available evidence
Purpose of review Coronavirus Disease 2019 (COVID19) has caused significant global morbidity and mortality, especially in persons with underlying cardiovascular disease. There have been concerns that lipid-lowering therapy (LLT) increases angiotensin-converting enzyme 2 levels. Conversely, pleiotropic effects of statins can theoretically protect against severe COVID19 infection, supporting evidence from other respiratory illnesses in which statin use probably confers benefit. Recent findings There is an abundance of studies that show that statins are safe and potentially protect against severe COVID19 infection ...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Update on apolipoprotein B
Purpose of review The 2019 European Society of Cardiology/European Atherosclerosis Society Guidelines concluded that apolipoprotein B (apoB) was a more accurate measure of cardiovascular risk and a better guide to the adequacy of lipid lowering than low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (HDL-C). Also, they stated that apoB can be measured more accurately than LDL-C or non-HDL-C. This strong endorsement of the central role of apoB contrasts with the limited endorsement of apoB by the 2018 American College of Cardiology/American Heart Association Multisociety Guidelines. ...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Role of VLDL receptor in atherogenesis
Purpose of review My group previously discovered and characterized the rabbit and human VLDL receptors. For more than 30 years, I have focused on research regarding the functions of VLDL receptors in the fields of lipoprotein metabolism and atherogenesis. In this review, I introduce the roles of VLDL receptors in lipoprotein metabolism under physiological conditions and in atherogenesis under nonphysiological conditions. Recent findings I propose that the VLDL receptor plays key roles in the metabolism of postprandial remnant lipoproteins in concert with lipoprotein lipase (LPL). Furthermore, I propound a new ...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Inhibition of angiopoietin-like 3 for the management of severe hypercholesterolemia
Purpose for review Despite the therapeutic advances for patients with severe hypercholesterolemia, particularly those with homozygous familial hypercholesterolemia (HoFH), most patients are unable to achieve target low-density lipoprotein cholesterol (LDL-C) levels with the current available standard lipid-lowering therapy (LLT). We review the role of angiopoietin-like 3 (ANGPTL3) inhibition as an additional therapeutic option for severe hypercholesterolemia, particularly HoFH. Recent findings Evinacumab is a monoclonal antibody against ANGPTL3, and reduces LDL-C independent of LDL-receptor activity. ANGPTL3 inh...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Editorial introduction
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: EDITORIAL INTRODUCTIONS Source Type: research

Angiopoietin-like protein 3 inhibitors and contemporary unmet needs in lipid management
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE Source Type: research

Combination lipid therapy: could teamwork make the dream work?
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE Source Type: research

Nonalcohol fatty liver disease: balancing supply and utilization of triglycerides
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is defined as the abnormal accumulation of lipids in the liver, called hepatic steatosis, which occurs most often as a concomitant of the metabolic syndrome. Its incidence has surged significantly in recent decades concomitant with the obesity pandemic and increasing consumption of refined carbohydrates and saturated fats. This makes a review of the origins of NAFLD timely and relevant. Recent findings This disorder, which shares histologic markers found in alcoholic fatty liver disease, was named NAFLD to distinguish it from the latter. Recently, howeve...
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

Lipid effects of glucagon-like peptide 1 receptor analogs
Purpose of review Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are becoming more prominent as a therapeutic choice in diabetes management and their use is being expanded to other indications, such as obesity. Dyslipidemia and cardiovascular disease are common co-morbidities in these populations and understanding the impact of this class of medications on the lipid profile may be an important consideration. Recent findings Several GLP-1RAs trials demonstrate them to be safe and potentially beneficial for cardiovascular outcomes; improvements in surrogate markers of atherosclerosis have also been observed....
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

Lipid effects of sodium-glucose cotransporter 2 inhibitors
Purpose of review Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used antihyperglycemic drugs that show remarkable cardiorenal protective effects in patients with or without type 2 diabetes. Furthermore, they are effective among patients across a wide range of baseline renal and cardiac function. Numerous mechanisms have been evaluated to understand these remarkable clinical benefits. From an early stage, these agents were noted to affect the plasma lipid profile. Here we review lipid profile alterations attributable to SGLT2 inhibitors and also some mechanisms explored in model systems and human studies....
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

Competing tissue-specific functions for the Tribbles-1 plasma lipid associated locus
Purpose of review The pseudokinase Tribbles-1 (TRIB1) remains the focus of intense research since genome-wide association studies (GWAS) associated it with multiple cardiometabolic traits in humans, including plasma lipids and atherosclerosis. This review highlights recent advances in understanding the function of TRIB1 and what outstanding questions remain. Recent findings Studies performed in a myeloid-specific Trib1 mouse model show that Trib1 contributes to foam cell formation, underscoring the importance of continued research into tissue-specific functions of TRIB1. Investigations of TRIB1 function in a 3D ...
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

Depression and cardiovascular disease
Purpose of review The purpose of this review is to outline the relationship between cardiovascular disease (CVD) and depression, both as a cause of and a result of CVD. Recent findings The prevalence of depression seems to be increasing in the general population. It is likely that depression will be even more of a problem for CVD patients in the post-COVID-19 pandemic era. New studies confirm the independent association of depression with later incident CVD, although perhaps not as strong as suggested by some previous studies. Depression seems to be becoming even more prevalent in CVD patients, with new...
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

The impact of race and ethnicity on lipoprotein(a) levels and cardiovascular risk
Purpose of review Lipoprotein(a) [Lp(a)] is a plasma circulating apoB100 (apoB) containing lipoprotein. It has a unique glycoprotein bound to the apoB100, apolipoprotein(a) [apo(a)]. The majority of the population expresses two apo(a) isoforms, when bound to apoB100 they create two circulating Lp(a) particles. Lp(a) levels are genetically determined and epidemiological studies have established elevated levels of Lp(a) to be a causal risk factor of cardiovascular disease (CVD). Lp(a) levels differ across racial groups and Blacks of Sub-Saharan decent have higher levels when compared to white. In comparison to white popu...
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

Polygenic risk scores: how much do they add?
Purpose of review Current methods to assess genetic risk of familial hypercholesterolemia and coronary artery disease (CAD) focus on testing monogenic mutations in well known genes. Here we review recent developments in polygenic risk scores (PRSs) for LDL cholesterol and for CAD, and how they may add to current risk prediction algorithms. Recent findings PRSs can identify 10–20 times as many individuals at high polygenic risk compared with monogenic mutations, and PRSs can modulate the effect of a monogenic variant on risk. Current risk factor prediction tools for prevention of CAD incompletely capture po...
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: LIPID METABOLISM Source Type: research

Editorial introduction
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - April 30, 2021 Category: Lipidology Tags: EDITORIAL INTRODUCTION Source Type: research

The clinical black, white, and gray lessons
Purpose of review This review examines recent contradictory large, well-controlled randomized control trials assessing the effects of omega-3 fatty acids and colchicine on cardiovascular (CV) outcomes. Recent findings The Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) and Statin Residual Risk Reduction with Epanova in high Cardiovascular Risk patients with Hypertriglyceridemia (STRENGTH) trial assessed the CV outcomes using high-dose omega-3 fatty acids in statin-treated patients with moderate hypertriglyceridemia and high-risk for CV disease with differing results. ...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE Source Type: research

Genetic variants associated with cardiovascular diseases and related risk factors highlight novel potential therapeutic approaches
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: BIMONTHLY UPDATE Source Type: research

Cross-species data integration to prioritize causal genes in lipid metabolism
Purpose of review More than one hundred loci have been identified from human genome-wide association studies (GWAS) for blood lipids. Despite the success of GWAS in identifying loci, subsequent prioritization of causal genes related to these loci remains a challenge. To address this challenge, recent work suggests that candidate causal genes within loci can be prioritized through cross-species integration using genome-wide data from the mouse. Recent findings Mouse model systems provide unparalleled access to primary tissues, like the liver, that are not readily available for human studies. Given the key role th...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Apolipoprotein genetic variants and hereditary amyloidosis
Purpose of review Amyloidosis is caused by the deposition of misfolded aggregated proteins called amyloid fibrils that in turn cause organ damage and dysfunction. In this review, we aim to summarize the genetic, clinical, and histological findings in apolipoprotein-associated hereditary amyloidosis and the growing list of mutations and apolipoproteins associated with this disorder. We also endeavor to summarize the features of apolipoproteins that have led them to be overrepresented among amyloidogenic proteins. Additionally, we aim to distinguish mutations leading to amyloidosis from those that lead to inherited dysli...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Update on cerebrotendinous xanthomatosis
Purpose of review Cerebrotendinous xanthomatosis (CTX) is a rare genetic lipid storage disorder with highly pleomorphic clinical phenotype. Complications of this disease can be devastating and may include severe cognitive impairment and dementia in later stages. Disease progression can be prevented or stabilized by bile acid replacement therapy, although a subset of patients with advanced disease continue to deteriorate despite therapy. Recent findings Delayed diagnosis of CTX continues to impede effective treatment. A clinical diagnostic algorithm for CTX was developed that can decrease the age of diagnosis of ...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Recent advances in ABCG5 and ABCG8 variants
Purpose of review In this review, we summarize the genetics and mechanisms of sitosterolemia and sterol trafficking, and provide an update on the understanding of the prevalence of ABCG5 and ABCG8 variants and their role in human disease. Recent findings Defects in ABCG5/G8 result in the accumulation of xenosterols. It had been previously thought that near total LoF of one of the proteins was required to cause pathology. However, recently there was the first report of a patient with Sitosterolemia who was heterozygous for mutations in both genes. Moreover, large population studies have demonstrated the even simp...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

The clinical applicability of polygenic risk scores for LDL-cholesterol: considerations, current evidence and future perspectives
Purpose of review The current review describes the development, clinical relevance and potential caveats of polygenic risk scores (PRS) for LDL cholesterol (LDL-C). Recent findings In recent years, a large number of common variants have been shown to have a small effect on LDL-C levels. The aggregate effect of all of these variants on LDL-C levels can be captured in a PRS and an elevated number of LDL-C increasing common variants is considered to be a cause of high LDL-C levels in patients with familial hypercholesterolemia (FH) without a large effect, rare mutation. PRS do not only serve as a tool in diagnostic...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance
Purpose of review Contemporary polygenic scores, which summarize the cumulative contribution of millions of common single-nucleotide variants to a phenotypic trait, can have effects comparable to monogenic mutations. This review focuses on the emerging use of ‘genome-wide’ polygenic scores for plasma lipoproteins to define the etiology of clinical dyslipidemia, modify the severity of monogenic disease, and inform therapeutic options. Recent findings Polygenic scores for low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein cholesterol are associated with severe hype...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Pharmacogenomics of statins and familial hypercholesterolemia
Purpose of review To collect evidence on statin pharmacogenomics, and review what is known in this field for familial hypercholesterolemia (FH) patients. Recent findings There are well-known associations between specific single nucleotide polymorphisms involved in statin transport and metabolism and either adverse effects or altered lipid-lowering efficacy. However, the applicability of this knowledge is uncertain, especially in high-risk populations. There are alternative approaches to study plasma concentrations of statins and new insights on why some association studies fail to be replicated. Summary S...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case
Purpose of review Polygenic scores (PGS) are used to quantify the genetic predisposition for heritable traits, with hypothesized utility for personalized risk assessments. Lipid PGS are primed for clinical translation, but evidence-based practice changes will require rigorous PGS standards to ensure reproducibility and generalizability. Here we review applicable reporting and technical standards for dyslipidemia PGS translation along phases of the ACCE (Analytical validity, Clinical validity, Clinical utility, Ethical considerations) framework for evaluating genetic tests. Recent findings New guidance suggests e...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

The genetic counselor's role in management of patients with dyslipidemia
Purpose of review The role of genetic testing in diagnosis and management of dyslipidemias continues to grow. Consequently, it is increasingly important for patients to have access to clinicians who have expertise in medical genetics and the psychological implications related to this type of testing. Often a lipidologist has had limited training in this regard, and this review explores the role of the genetic counselor to fill this gap. Recent findings Genetic counselors are key members of the healthcare team, and their specialized training in medical genetics and counseling allows them to fill this professional...
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Editorial comment: hazards of interpreting genetic reports
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Editorial comment: when Mendelian randomization goes astray
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research

Editorial introduction
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 4, 2021 Category: Lipidology Tags: EDITORIAL INTRODUCTION Source Type: research

Triglycerides as target of cardiovascular risk reduction
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - December 24, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

Atherosclerosis: cell biology and lipoproteins
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - December 24, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research

The COVID-19 pandemic: lifestyle and cardiovascular risk factors
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - December 24, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research