The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells.

CONCLUSIONS: Simvastatin restored the expression of BIM to induce apoptotic cell death in NSCLC cells harboring an EGFR-resistant mutation. Our study suggests the potential utility of simvastatin as a BIM-targeted treatment for NSCLC. PMID: 26756263 [PubMed - in process]
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research