The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells.
CONCLUSIONS: Simvastatin restored the expression of BIM to induce apoptotic cell death in NSCLC cells harboring an EGFR-resistant mutation. Our study suggests the potential utility of simvastatin as a BIM-targeted treatment for NSCLC.
PMID: 26756263 [PubMed - in process]
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
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