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Source: Molecular Medicine Reports
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Total 308 results found since Jan 2013.
BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF ‑κB signaling pathway in glomerular mesangial cells.
In conclusion, BAFF enhanced the expression of fibroblast factors in the kidneys by activating the TRAF6/NF‑κB signaling pathway.
PMID: 31974601 [PubMed - in process]
Source: Molecular Medicine Reports - January 26, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1.
Authors: Lu M, Yi T, Xiong Y, Wang Q, Yin N
Abstract
Cortex Mori Radicis extract (CMR) has various pharmacological properties, such as anti‑inflammatory, anti‑allergic and anti‑hyperglycemic effects. However, the effects and mechanisms of CMR in the neuroregeneration of diabetic peripheral neuropathy (DPN) are unclear. In the present study, the effects of CMR on neurite outgrowth of dorsal root ganglia (DRG) neurons in diabetic rats were investigated and its underlying mechanisms were explored. SD rats were subjected to a high‑fat diet with low‑dose streptozotocin to induce a Type II diabetes model with p...
Source: Molecular Medicine Reports - January 16, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA Unigene56159 promotes glioblastoma multiforme cell proliferation and invasion through negatively regulating microRNA‑194‑5p.
Long non‑coding RNA Unigene56159 promotes glioblastoma multiforme cell proliferation and invasion through negatively regulating microRNA‑194‑5p.
Mol Med Rep. 2019 Nov 26;:
Authors: Jiang G, Dong H, Dong Y, Yang X
Abstract
Long non‑coding RNAs (lncRNA) serve a vital role in tumor progression. The present study identified a fundamental role for a novel lincRNA, Unigene56159, in the progression of glioblastoma (GBM). Unigene56159 gene expression was found to be significantly upregulated in tissue samples from patients with GBM as well as in GBM cell lines by reverse transcription‑quantitative PC...
Source: Molecular Medicine Reports - December 5, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine ‑functionalized magnetic iron oxide nanoparticles on LX‑2 cells.
Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine‑functionalized magnetic iron oxide nanoparticles on LX‑2 cells.
Mol Med Rep. 2019 Nov 20;:
Authors: Yu Q, Xiong X, Zhao L, Xu T, Wang Q
Abstract
Connective tissue growth factor (CTGF) is a possible key determinant of progressive fibrosis. Nanotechnology has been considered as a potential tool for developing novel drug delivery systems for various diseases, including liver fibrosis. The present study aimed to investigate the potential antifibrotic activity of CTGF small interfering RNA (si...
Source: Molecular Medicine Reports - November 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
House dust mite induces Sonic hedgehog signaling that mediates epithelial ‑mesenchymal transition in human bronchial epithelial cells.
House dust mite induces Sonic hedgehog signaling that mediates epithelial‑mesenchymal transition in human bronchial epithelial cells.
Mol Med Rep. 2019 Sep 26;:
Authors: Zou Y, Song W, Zhou L, Mao Y, Hong W
Abstract
Epithelial‑mesenchymal transition (EMT) provides a valuable source of fibroblasts that produce extracellular matrix in airway walls. The Sonic hedgehog (SHH) signaling pathway plays an essential role in regulating tissue turnover and homeostasis. SHH is strikingly upregulated in the bronchial epithelia during asthma. Snail1 is a major target of SHH signaling, which regulates EMT and fib...
Source: Molecular Medicine Reports - November 10, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ACSS2/AMPK/PCNA pathway ‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress.
This study investigated the functions of nutrient stress (NS)‑mediated acetyl‑CoA synthetase short‑chain family member 2 (ACSS2) in cell proliferation and cisplatin‑resistance and examined its combined effects with proliferating cell nuclear antigen (PCNA), a key regulator of DNA replication and repair. Here, it was demonstrated that under NS, when the AMP‑activated protein kinase (AMPK) pathway was activated, ESCC cells maintained proliferation and chemoresistance was distinctly upregulated as determined by CCK‑8 assay. As determined using immunoblotting and RT‑qPCR, compared with normal esophageal epithelia...
Source: Molecular Medicine Reports - October 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Effects of hypoxia ‑inducible factor‑1α on the proliferation and apoptosis of human synovial mesenchymal stem cells.
In conclusion, HIF‑1α effectively improved the tolerance of SMSCs to hypoxia, which may promote cellular proliferation and prevent the apoptosis of SMSCs under hypoxic conditions.
PMID: 31545415 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Regulatory mechanism of NOV/CCN3 in the inflammation and apoptosis of lung epithelial alveolar cells upon lipopolysaccharide stimulation.
In conclusion, our data indicate that CCN3 knockdown affects the expression of downstream genes through the TGF‑β/p‑Smad or NF‑κB pathways, leading to the inhibition of cell inflammation and apoptosis in human alveolar epithelial cells.
PMID: 31545412 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Phospho ‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation.
In conclusion, PLK1 promoted cell proliferation and insulin secretion while inhibiting cellular apoptosis in β‑TC3 cell lines under both low and high glucose conditions. In addition, the phospho‑regulation of Cdc14A by PLK1 may be involved in β‑TC3 cell cycle regulation and insulin secretion under high glucose conditions.
PMID: 31545409 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA SLNCR1 regulates non‑small cell lung cancer migration, invasion and stemness through interactions with secretory phospholipase A2.
In conclusion, lncRNA SLNCR1 may regulate cancer cell migration, invasion and stemness in NSCLC through interactions with sPLA2.
PMID: 31524254 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 17, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Expression and significance of Annexin A3 in the osteosarcoma cell lines HOS and U2OS.
Authors: Zeng X, Wang S, Gui P, Wu H, Li Z
Abstract
Annexin A3 (ANXA3) is highly expressed in different types of cancers, but the impact of ANXA3 in bone tumors is still not clear. In the present study, the expression of ANXA3 in osteosarcoma cells was first confirmed by cellular immunofluorescence. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis were used to detect the expression of ANXA3 in osteoblasts in the osteosarcoma cell lines U2OS and HOS. Furthermore, small interfering (si)‑RNA were transfected into U2OS and HOS cells via a liposome‑mediated method....
Source: Molecular Medicine Reports - September 17, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Synergistic effect of STAT3 ‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo.
Synergistic effect of STAT3‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo.
Mol Med Rep. 2019 Aug 21;:
Authors: Liu Q, Wang L, Li D, Zhao J, Chen S, Li J
Abstract
The aim of this study was to explore the synergistic effect of signal transducer and activator of transcription 3 (STAT3)‑targeted small interfering (si)RNA and AZD0530 against glioblastoma in vitro and in vivo. Glioblastoma cell lines U87 and U251 were divided into four groups and treated with control, LV‑STAT3 siRNA, AZD0530, and combined LV‑STAT3 siRNA with AZD0530, respectively. The proli...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Microtubule ‑severing protein Katanin p60 ATPase‑containing subunit A‑like 1 is involved in pole‑based spindle organization during mouse oocyte meiosis.
Microtubule‑severing protein Katanin p60 ATPase‑containing subunit A‑like 1 is involved in pole‑based spindle organization during mouse oocyte meiosis.
Mol Med Rep. 2019 Aug 22;:
Authors: Gao LL, Xu F, Jin Z, Ying XY, Liu JW
Abstract
Microtubule‑severing proteins (MTSPs) are a group of microtubule‑associated proteins essential for multiple microtubule‑related processes, including mitosis and meiosis. Katanin p60 ATPase‑containing subunit A‑like 1 (p60 katanin‑like 1) is an MTSP that maintains the density of spindle microtubules at the poles in mitotic cells; however, to date, there...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Sam68 mediates high glucose ‑induced podocyte apoptosis through modulation of Bax/Bcl‑2.
This study sought to examine the effect of Sam68 on high glucose (HG)‑induced podocytes apoptosis, and the mechanism underlying this effect. Immortalized mouse podocytes were exposed to medium containing normal glucose, or HG and Sam68 siRNA, respectively. The expression of Sam68 in podocytes was determined by fluorescence quantitative PCR (qPCR), immunofluorescence and immunoblotting. The role of Sam68 in HG‑induced podocyte apoptosis was further evaluated by inhibiting Sam68 expression by Sam68 siRNA and performing flow cytometry. The mRNA and protein expression of pro‑apoptosis gene Bax and anti‑apoptotic gene B...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro.
Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro.
Mol Med Rep. 2019 Sep 02;:
Authors: Sun R, Yang Y, Gu Z, Tang X, Zhang C, Kou W, Wei P
Abstract
The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
