Regulatory mechanism of NOV/CCN3 in the inflammation and apoptosis of lung epithelial alveolar cells upon lipopolysaccharide stimulation.

In conclusion, our data indicate that CCN3 knockdown affects the expression of downstream genes through the TGF‑β/p‑Smad or NF‑κB pathways, leading to the inhibition of cell inflammation and apoptosis in human alveolar epithelial cells. PMID: 31545412 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research