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Source: Molecular Medicine Reports
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Total 308 results found since Jan 2013.
Downregulation of caspase ‑3 alleviates Mycoplasma pneumoniae‑induced apoptosis in alveolar epithelial cells.
Downregulation of caspase‑3 alleviates Mycoplasma pneumoniae‑induced apoptosis in alveolar epithelial cells.
Mol Med Rep. 2017 Oct 12;:
Authors: Shi S, Liu X, Li H
Abstract
Mycoplasma pneumoniae (M. pneumoniae) infection is closely associated with pneumonia in children. Apoptosis of alveolar epithelial cells is involved in the development of pneumonia in children. The present study aimed to examine how caspase‑3 influences apoptosis rates in M. pneumoniae‑infected alveolar epithelial cells. A549 alveolar epithelial cells were treated with M. pneumoniae, and cells and culture supernatant we...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Oxidized low density lipoprotein facilitates tumor necrosis factor ‑α mediated chondrocyte death via autophagy pathway.
Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway.
Mol Med Rep. 2017 Oct 13;:
Authors: Shen P, Zhu Y, Zhu L, Weng F, Li X, Xu Y
Abstract
We aimed to investigate the role of oxidized low density lipoprotein (ox‑LDL) in tumor necrosis factor‑α (TNF‑α) mediated chondrocyte death and explore the mechanisms. Ten osteoarthritis (OA) and normal control cartilage tissue and synovial fluid (SF) samples were collected, and the expression of lectin‑like ox‑LDL receptor‑1 (LOX‑1) and ox‑LDL level was examined by real time quan...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SiRNA directed against NF ‑κB inhibits mononuclear macrophage cells releasing proinflammatory cytokines in vitro.
SiRNA directed against NF‑κB inhibits mononuclear macrophage cells releasing proinflammatory cytokines in vitro.
Mol Med Rep. 2017 Oct 04;:
Authors: Wu C, Zhao J, Zhu G, Huang Y, Jin L
Abstract
Acute lung injury (ALI) is a condition of acute respiratory failure, characterized by diffuse pulmonary infiltrates and severe hypoxemia. During ALI, the acute phase of inflammation induces the recruitment of activated inflammatory cells, including macrophages and lymphocytes, to the damaged lesions. Nuclear factor (NF)‑κB is a key protein in many signal transduction pathways, over‑activation of which i...
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Diagnostic and prognostic value of serum interleukin ‑16 in patients with gastric cancer.
In conclusion, the current results indicate that serum IL‑16 levels may have diagnostic and prognostic value for patient with GC.
PMID: 28990054 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
TRPC1 stimulates calcium ‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells.
TRPC1 stimulates calcium‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells.
Mol Med Rep. 2017 Aug 04;:
Authors: Qu YY, Wang LM, Zhong H, Liu YM, Tang N, Zhu LP, He F, Hu QH
Abstract
Store‑operated Ca2+ entry (SOCE) via store‑operated Ca2+ channels (SOCC), encoded by transient receptor potential canonical (TRPC) channel proteins, is an important underlying mechanism regulating intracellular Ca2+ concentration ([Ca2+]i) and various intracellular functions in endothelial cells (ECs). TRPC1, the probable candidate for SOCC, is expressed in ECs. Ca...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer.
Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer.
Mol Med Rep. 2017 Aug 03;:
Authors: Su JC, Hu XF
Abstract
Breast cancer is one of the most frequently occurring malignancies in female cancers worldwide, however, its detailed mechanism of tumorigenesis remains to be elucidated. Long non-coding RNAs (LncRNAs) have previously been demonstrated to be important in multiple cancers, including breast cancer. The present study aimed to elucidate the molecular mechanism of the effects of the novel Lnc RNA HOXA11‑AS, on cell proliferation and metastasis in br...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Suppression of TAFI by siRNA inhibits invasion and migration of breast cancer cells.
Authors: Yu C, Luan Y, Wang Z, Zhao J, Xu C
Abstract
Human thrombin activatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2), is a procarboxypeptidase enzyme. The purpose of the present study was to observe the expression of TAFI in breast cancer (BC) and breast cancer cell (BCC) lines and to investigate the effect of TAFI suppression by small interfering (si)RNA gene silencing on invasion and migration of BCC lines. A significant increase in TAFI level was identified by immunohistochemical analysis in BC tissues compared with normal breast tissues. TAFI suppression also inhibited cell vi...
Source: Molecular Medicine Reports - August 4, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
E ‑cadherin involvement in human lens epithelial cell transdifferentiation may be associated with N‑cadherin.
E‑cadherin involvement in human lens epithelial cell transdifferentiation may be associated with N‑cadherin.
Mol Med Rep. 2017 Aug 02;:
Authors: Huang L, Jiang J, Guo Q, Yang H
Abstract
E-cadherin, β-catenin and N‑cadherin serve key roles in the epithelial‑to‑mesenchymal transition (EMT) that leads to human lens epithelial cell (LEC) transdifferentiation and subsequent cataract formation. The present study aimed to investigate the role of E‑cadherin in LEC transdifferentiation. SRA01/04 human LECs were transfected with E‑cadherin short interfering (si)RNA (E‑cadherin siRNA group), nega...
Source: Molecular Medicine Reports - August 4, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Endothelial semaphorin 7A promotes seawater aspiration-induced acute lung injury through plexin C1 and β1 integrin.
Authors: Zhang M, Yan X, Liu W, Sun R, Xie Y, Jin F
Abstract
Inflammation and edema are two main characteristics in seawater aspiration‑induced acute lung injury (ALI). In a previous study of the authors, it was demonstrated that endothelial semaphorin 7A (SEMA7A) serves an important role in the development of seawater‑induced inflammation and edema. However, the mechanism of endothelial SEMA7A‑mediated ALI remains unclear. Therefore, the authors explored the effect of SEMA7A in rat pulmonary microvascular endothelial cells (RPMVECs) and the interaction between endothelial SEMA7A and alveolar macrophages duri...
Source: Molecular Medicine Reports - August 4, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin ‑C via Wnt/β‑catenin pathway.
In conclusion, the results of the present study suggested that ATF3 promotes macrophage migration and reverses M1‑polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/β‑catenin signaling pathway.
PMID: 28714032 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Effect of CCL2 siRNA on proliferation and apoptosis in the U251 human glioma cell line.
In conclusion, CCL2 siRNA exhibited effective inhibition of cell proliferation and angiogenesis in the glioma cell line U251, which may provide a theoretical basis for the use of CCL2 in in vivo research and clinical treatment as a novel anticancer agent.
PMID: 28714025 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Adipose differentiation ‑related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation.
Adipose differentiation‑related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation.
Mol Med Rep. 2017 Jul 15;:
Authors: Zhao H, Han T, Hong X, Sun D
Abstract
Vascular smooth muscle cells (VSMCs) have an important role in atherosclerosis development. Evidence has demonstrated that adipose differentiation‑related protein (ADRP) is associated with foam cell formation and atherosclerosis progression. However, to the best of our knowledge, no previous studies have investigated the role of ADRP knockdown in platelet‑derived growth facto...
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
A systematic study of Girdin on cell proliferation, migration and angiogenesis in different breast cancer subtypes.
In conclusion, these data indicate that Girdin knockdown suppressed cell viability and migration and may suppress angiogenesis via the PI3K/Akt signaling pathway, in various breast cancers subtypes. The present study therefore suggests a role for Girdin as a novel therapeutic target for breast cancer, independent of subtype.
PMID: 28713924 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Effects of lentiviral vector ‑mediated shRNA silencing of TGFβ1 on the expression of Col1a1 in rat hepatic stellate cells.
Effects of lentiviral vector‑mediated shRNA silencing of TGFβ1 on the expression of Col1a1 in rat hepatic stellate cells.
Mol Med Rep. 2017 Jul 06;:
Authors: Bai GP, Yan GH, Wang GJ, Wan P, Liu XF, Wang H, Zhang RH
Abstract
The present study aimed to construct a lentiviral RNA interference (RNAi) vector targeting the transforming growth factor β1 (TGFβ1) gene of rats, in order to examine its effect on silencing of the TGFβ1 gene and on the expression of collagen type 1 α1 (Col1a1) in HSC‑T6 rat hepatic stellate cells. Three RNAi sites of the TGFβ1 gene were selected according to its CDs seque...
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF ‑β1/Smad3 signaling pathway.
NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway.
Mol Med Rep. 2017 Jul 14;:
Authors: Zhou H, Yu X, Zhou G
Abstract
The proliferation of cardiac fibroblasts (CFs) and excessive deposition of extracellular matrix are the predominant pathological characteristics of cardiac fibrosis. As the largest member of the nucleotide‑binding domain and leucine‑rich repeat (NLR) family, NLRC5 has been shown to be pivotal in the development of hepatic fibrosis. However, whether NLRC5 is involved in the pathogenesis of cardiac fibrosis remains to be elucidated. The pr...
Source: Molecular Medicine Reports - July 19, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
