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Exogenous sodium hydrosulfide protects against high glucose ‑induced injury and inflammation in human umbilical vein endothelial cells by inhibiting necroptosis via the p38 MAPK signaling pathway.
In conclusion, the findings of the present study indicated that NaHS may protect HUVECs against HG‑induced injury and inflammation by inhibiting necroptosis via the p38 MAPK signaling pathway, which may represent a promising drug for the therapy of diabetic vascular complications. PMID: 33215220 [PubMed - in process]
Source: Molecular Medicine Reports - November 21, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Protective effects of valsartan administration on doxorubicin ‑induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling.
Protective effects of valsartan administration on doxorubicin‑induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling. Mol Med Rep. 2020 Nov;22(5):4151-4162 Authors: Cheng D, Chen L, Tu W, Wang H, Wang Q, Meng L, Li Z, Yu Q Abstract Clinical application of doxorubicin (DOX) is hampered by its potential cardiotoxicity, however angiotensin receptor blockers could attenuate DOX‑induced cardiomyopathy. The present study tested the hypothesis that simultaneous administration of valsartan (Val) with DOX could prevent DOX‑induced myocardial injury by modulating myoca...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Neuropeptide  Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism.
Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism. Mol Med Rep. 2020 Nov;22(5):4376-4382 Authors: Zhang B, Zhang X, Xiao J, Zhou X, Chen Y, Gao C Abstract The neuropeptide Y (NPY) system is considered one of the primary neural signaling pathways. NPY, produced by osteoblasts and other peripheral tissues, is known to inhibit biological functions of osteoblasts. However, until recently, little was known of the autocrine mechanism by which NPY is regulated. To investigate this mechanism, overexpression plasmids and small interferi...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of PEG anchors in PEGylated siRNA lipoplexes on in  vitro gene‑silencing effects and siRNA biodistribution in mice.
Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution in mice. Mol Med Rep. 2020 Nov;22(5):4183-4196 Authors: Hattori Y, Tamaki K, Sakasai S, Ozaki KI, Onishi H Abstract Polyethylene glycol (PEG)‑modifications (PEGylations) of cationic liposome/small interfering RNA complexes (siRNA lipoplexes) can enhance their systemic stability. The present study determined the effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution after intravenous injection. Three types of dialkyl or trial...
Source: Molecular Medicine Reports - October 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Melatonin ‑induced miR‑181c‑5p enhances osteogenic differentiation and mineralization of human jawbone‑derived osteoblastic cells.
In conclusion, MEL‑induced expression of miR‑181c‑5p enhanced osteogenic differentiation and calcification of hOB cells. PMID: 32945514 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 20, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effect of pre ‑freezing and saccharide types in freeze‑drying of siRNA lipoplexes on gene‑silencing effects in the cells by reverse transfection.
Effect of pre‑freezing and saccharide types in freeze‑drying of siRNA lipoplexes on gene‑silencing effects in the cells by reverse transfection. Mol Med Rep. 2020 Aug 05;: Authors: Tang M, Hu S, Hattori Y Abstract Our previous study reported that reverse (Rev)‑transfection with small interfering RNA (siRNA)/cationic liposome complexes (siRNA lipoplexes) freeze‑dried in trehalose or sucrose solution resulted in high gene‑silencing activity in cells. The current study investigated whether pre‑freezing or saccharide types present during the freeze‑drying of siRNA lipoplexes affected geneâ€...
Source: Molecular Medicine Reports - September 20, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim.
MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim. Mol Med Rep. 2020 Sep 02;: Authors: Zhao Z, Zheng J, Ye Y, Zhao K, Wang R, Wang R Abstract Intervertebral disc degeneration (IDD) is a degenerative disease of the spine originating from the intervertebral disc. MicroRNAs (miRNAs or miRs) are a group of endogenous small non‑coding RNAs that act on target genes and play a critical role in numerous biological processes. However, the underlying mechanism of miR‑25‑3p in IDD remains unclear. Therefore, the present ...
Source: Molecular Medicine Reports - September 10, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll ‑like receptor 2/4 signaling pathways.
RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll‑like receptor 2/4 signaling pathways. Mol Med Rep. 2020 Jun 16;: Authors: Huang W, Yang J, He C, Yang J Abstract The revascularization of blood vessels after myocardial infarction can lead to serious myocardial damage. Previous studies showed that radioprotective 105 kDa protein (RP105) is a specific negative regulator of myocardial ischemia reperfusion injury (MIRI). RP105 can modulate the Toll‑like receptor (TLR)2/TLR4 signaling pathways. However, the synergistic effect of TLR2/4 regulated by RP1...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression.
MicroRNA‑34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression. Mol Med Rep. 2020 Jun 15;: Authors: Yin W, Gao F, Zhang S Abstract MicroRNAs (miRs) are potential therapeutic targets for tumors. The aims of the present study were to investigate the regulatory effects of miR‑34a on the proliferation, apoptosis and chemosensitivity of retinoblastoma (RB) cells, and to identify the possible underlying mechanism involving Notch1. It was found that miR‑34a was downregulated, and Notch1 was upregulated in HXO‑RB44 and Y79 cells. In...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Troxerutin attenuates oxygen ‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes.
Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes. Mol Med Rep. 2020 Jun 03;: Authors: Yu ZP, Yu HQ, Li J, Li C, Hua X, Sheng XS Abstract Myocardial ischemia‑reperfusion (MI/R) injury is a complex pathological process that occurs when tissues are reperfused following a prolonged period of ischemia. Troxerutin has been reported to have cardioprotective functions. However, the underlying mechanism by which troxerutin protects against MI/R injury has not been fully ...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulation of miR ‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2.
Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2. Mol Med Rep. 2020 Apr 24;: Authors: Wu W, Shang Y, Dai S, Yu C, Wang J Abstract The increased proliferation and migration of vascular smooth muscle cells (VSMCs) are critical in the progression of atherosclerosis (AS). Platelet‑derived growth factor type BB (PDGF‑BB) may induce VSMC proliferation and migration. miR‑142‑5p plays a critical role in various biological processes, including tumorigenesis, angiogenesis and inflammation. However, whether miR‑142‑5p is involved ...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

HIF ‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions.
HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions. Mol Med Rep. 2020 Apr 01;: Authors: Zhang Z, Huang C, Wang P, Gao J, Liu X, Li Y, Yan S, Shi Y Abstract Preeclampsia (PE) is a pregnancy-specific syndrome that has severe implications on perinatal mortality and morbidity. Excessive apoptosis of trophoblasts induced by hypoxia may be associated with the development of PE, but the exact pathogenesis is unknown. Forkhead box O transcription factor 3a (FOXO3a) is activated under hypoxic conditions. Furthermore, hypoxia‑inducib...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mechanisms of impaired pancreatic β‑cell function in high‑fat diet‑induced obese mice: The role of endoplasmic reticulum stress.
Authors: Yi X, Cai X, Wang S, Xiao Y Abstract The aim of the study was to examine whether there was excessive endoplasmic reticulum stress (ERs) in the islets of high‑fat diet (HFD)‑induced obese mice, as well as the effects of ERs on β‑cell function. Male C57BL/6J mice were fed a HFD for 16 weeks. Pancreatic β‑cell function was evaluated using intraperitoneal glucose tolerance and insulin release tests, and via electron microscopy. The expression of activating transcription factor 6 (ATF6) and phosphorylated (p)‑eukaryotic initiation factor 2α (eIF2α) were detected via immunofluorescence staining to...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in  vitro.
AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in vitro. Mol Med Rep. 2020 Jan 31;: Authors: Zong L, Zhao J, Wu W, Wang J, Huang D, Liu M Abstract The underlying mechanism involved in auditory neuropathy spectrum disorder (ANSD) remains largely unclear. It has been previously reported that mutations in the apoptosis‑inducing factor (AIF) gene are associated with auditory neuropathy and delayed peripheral neuropathy, which can eventually cause ANSD. In the present study, the regulatory effects of AIF knockdown on the cellular functions of spiral gangl...
Source: Molecular Medicine Reports - April 24, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway.
In conclusion, laminin α5 could modulate fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway. PMID: 32016453 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - February 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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