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Source: Molecular Medicine Reports
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Total 308 results found since Jan 2013.
Nkx2.5/CARP signaling pathway contributes to the regulation of ion channel remodeling induced by rapid pacing in rat atrial myocytes.
Authors: Wang W, Zhu Y, Yi J, Cheng W
Abstract
Remodeling of atrial electrophysiology and structure is the primary feature of atrial fibrillation (AF). Evidence suggests that abnormalities in the expression levels of embryological cardiovascular development‑associated transcription factors, including Nkx2.5, are crucial for the development of AF. Rat atrial myocardial cells (AMCs) in culture dishes were placed in an electric field and stimulated. Transmission electron microscopy was used to observe the ultrastucture prior to and following rapid pacing. The action potential durations and effective refractory perio...
Source: Molecular Medicine Reports - September 10, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SH003 selectively induces p73 ‑dependent apoptosis in triple‑negative breast cancer cells.
SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cells.
Mol Med Rep. 2016 Sep 6;
Authors: Choi EK, Kim SM, Hong SW, Moon JH, Shin JS, Kim JH, Hwang IY, Jung SA, Lee DH, Lee EY, Lee S, Kim H, Kim D, Kim YS, Choi YK, Kim HI, Choi HS, Cho SG, Kim JE, Kim KP, Hong YS, Lee WK, Lee JS, Kim TW, Ko SG, Jin DH
Abstract
Triple-negative breast cancer (TNBC) is a breast cancer subtype that has an aggressive phenotype, is highly metastatic, has limited treatment options and is associated with a poor prognosis. In addition, metastatic TNBC has no preferred standard chemotherapy ...
Source: Molecular Medicine Reports - September 10, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Impact of siRNA targeting of β-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damage.
Authors: Zhang X, Zhu C, Luo Q, Dong J, Liu L, Li M, Zhu H, Ma X, Wang J
Abstract
The aim of the present study was to investigate the possible damage-repair mechanisms of neural stem cells (NSCs) following hypoxic-ischemic brain damage (HIBD). NSCs obtained from Sprague Dawley rats were treated with tissue homogenate from normal or HIBD tissue, and β‑catenin expression was silenced using siRNA. The differentiation of NSCs was observed by immunofluorescence, and semiquantitative reverse transcription‑polymerase chain reaction and western blot analysis were applied to detect the mRNA and protein expression level...
Source: Molecular Medicine Reports - September 1, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cells.
In conclusion, ALCAM is upregulated in PSCs of pancreatic cancer tissues, suggesting a potential role of ALCAM in regulating pancreatic cancer cell‑PSC interactions.
PMID: 27573419 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 1, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy.
In conclusion, these data demonstrate that the miR‑558/AATK cascade is important for the radiosensitization of lung cancer cells and may be a potential radiotherapy target.
PMID: 27485693 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - August 5, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Resveratrol inhibits phosphorylation within the signal transduction and activator of transcription 3 signaling pathway by activating sirtuin 1 in SW1353 chondrosarcoma cells.
Resveratrol inhibits phosphorylation within the signal transduction and activator of transcription 3 signaling pathway by activating sirtuin 1 in SW1353 chondrosarcoma cells.
Mol Med Rep. 2016 Jul 27;
Authors: Jin H, Chen H, Yu K, Zhang J, Li B, Cai N, Pan J
Abstract
The present study assessed the mechanism by which resveratrol (Res) inhibits the growth of SW1353 chondrosarcoma cells and examined whether sirtuin 1 (Sirt1) activation affects phosphorylation within the signal transduction and activator of transcription 3 (STAT3) signaling pathway. The present study used SW1353 chondrosarcoma c...
Source: Molecular Medicine Reports - August 5, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Silencing of osterix expression by siRNA inhibits aldosterone ‑induced calcification of vascular smooth muscle cells in mice.
Silencing of osterix expression by siRNA inhibits aldosterone‑induced calcification of vascular smooth muscle cells in mice.
Mol Med Rep. 2016 Jul 8;
Authors: Gong YC, He Y, Wang H, Niu WQ, Ji KD, Li H
Abstract
The process of vascular calcification shares numerous similarities with that of skeletal mineralization and involves the deposition of hydroxyapatite crystals in arteries and cardiac valves. However, the underlying cellular mechanism remains to be fully elucidated. Microarray analysis in the present study demonstrated that greater than 2,000 genes were upregulated during the calcification of ...
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
The anti ‑dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression.
The anti‑dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression.
Mol Med Rep. 2016 Jul 13;
Authors: Bryan-Marrugo OL, Arellanos-Soto D, Rojas-Martinez A, Barrera-Saldaña H, Ramos-Jimenez J, Vidaltamayo R, Rivas-Estilla AM
Abstract
Dengue virus (DENV) susceptibility to cholesterol depleting treatments has been previously reported. There are numerous questions regarding how DENV seizes cellular machinery and cholesterol to improve viral production and the effect of cholesterol sequestering agents on the cellular antiviral response. The aim of...
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Decreasing the ratio of matriptase/HAI‑1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer.
Authors: Sun P, Jiang Z, Chen X, Xue L, Mao X, Ruan G, Song Y, Mustea A
Abstract
Tumor invasion and metastasis are complex biological processes. Matriptase and its endogenous inhibitor, hepatocyte growth factor activator inhibitor‑1 (HAI‑1) are involved in invasion and metastasis. To evaluate the ratio of matriptase/HAI‑1 and their potential therapeutic value in ovarian cancer, HO‑8910 human ovarian cancer cells and the homologous high‑metastatic HO‑8910PM cells were used as in vitro cellular models ovarian cancer. The invasive and metastatic abilities, and the expression of matriptase and HAI‑1 in t...
Source: Molecular Medicine Reports - July 2, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma.
Authors: Dai W, Miao H, Fang S, Fang T, Chen N, Li M
Abstract
Aberrant expression of CDKN3 may be involved in carcinogenesis of liver cancer. The effect of CDKN3 on tumorigenesis and the molecular mechanisms involved have not been fully elucidated. Immunohistochemistry was performed to detect CDKN3 expression levels in tumor tissues. CDKN3 siRNA was used to knockdown CDKN3 in QGY7701 hepatocellular carcinoma (HCC) cells. Colony formation assay was used to measure the clonogenic capacity of the tumor cells. Cell viability was determined by MTT assay. Logistic regression was performed to analyze the association betwe...
Source: Molecular Medicine Reports - June 18, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
N-ethylmaleimide‑sensitive factor siRNA inhibits the release of Weibel-Palade bodies in endothelial cells.
Authors: Zhou Y, Yang SX, Yue YN, Wei XF, Liu Y
Abstract
The aim of the present study was to examine the effect of small interfering RNA (siRNA) methods on the expression of N‑ethylmaleimide sensitive factor (NSF) and Weibel‑Palade body (WPB) release in endothelial cells. A small hairpin RNA (shRNA), mediated with an adenovirus vector, was designed to target the N‑terminal functional area of NSF. Subsequently, viruses were transfected into human aortic endothelial cells. The mRNA and protein expression levels of NSF were detected using reverse transcription‑quantitative polymerase chain reaction and Western...
Source: Molecular Medicine Reports - June 11, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
High glucose-induced fibronectin upregulation in cultured mesangial cells involves caveolin-1-dependent RhoA-GTP activation via Src kinase.
In conclusion, HG‑induced FN upregulation requires caveolae and caveolin‑1 to interact with RhoA and Src kinases. Interference with Src/caveolin-1/RhoA signaling may provide novel mechanistic targets for the treatment of DKD.
PMID: 27220778 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - May 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SDF‑1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF‑κB pathway.
In conclusion, the SDF‑1/CXCR4 axis promoted cell apoptosis in human degenerative NPCs via the NF‑κB pathway, thus suggesting that SDF‑1/CXCR signaling may be a therapeutic target for the treatment of degenerative IVD diseases.
PMID: 27220474 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - May 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Effects of platelet-derived growth factor on chondrocyte proliferation, migration and apoptosis via regulation of GIT1 expression.
Authors: Zhao GZ, Zhang LQ, Liu Y, Fang J, Li HZ, Gao KH, Chen YZ
Abstract
The formation of fibrocartilage, cartilaginous and bony calluses is vital for bone healing following a fracture. Fibroblasts, chondrocytes and osteoblasts are critical functional cells that are involved in these three processes, respectively. Platelet‑derived growth factor (PDGF), a growth factor that is released from platelet particles and appears during the early stages at the site of fractures, is essential in bone healing via regulation of cell proliferation and differentiation. However, the effects of PDGF on the chondrocytes remain u...
Source: Molecular Medicine Reports - May 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
The prognostic role and reduced expression of FOXJ2 in human hepatocellular carcinoma.
Authors: Zhang Z, Meng G, Wang L, Ma Y, Guan Z
Abstract
The current study aimed to investigate the potential role of the FOXJ2 (forkhead box J2) protein in the pathology of hepatocellular carcinoma (HCC). Western blotting was performed to determine the expression levels of FOXJ2 in HCC tissues and HCC cells. Specimens from 110 patients with HCC undergoing hepatic resection were evaluated for FOXJ2 expression using an immunohistochemical assay. The correlation between FOXJ2 expression and clinicopathological factors of the patients was determined by statistical analysis to determine the prognostic merit of FOXJ2 e...
Source: Molecular Medicine Reports - May 15, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
