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Source: Molecular Medicine Reports

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Total 308 results found since Jan 2013.

Expression of NLRC4 in children with septicaemia and mechanisms of NLRC4 in in vitro cytokine secretion.
Authors: Zhu G, Chen J, Tian J, Ge L, Xing A, Tang G Abstract Septicaemia, a systemic bacterial infection, frequently leads to morbidity and mortality in children. The NOD-like receptor (NLR) family, CARD domain containing 4 (NLRC4) is involved in the control of infections. The aim of the present study was to detect the expression of NLRC4 in the blood samples of children with septicaemia, in addition to investigating the importance of NLRC4 in cytokine production, and the signaling pathways that regulate NLRC4 expression in lipopolysaccharide (LPS)-stimulated macrophages. It was determined that when compared with...
Source: Molecular Medicine Reports - May 15, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

High salt medium activates RhoA/ROCK and downregulates eNOS expression via the upregulation of ADMA.
Authors: Cao Y, Fang Y, Mu J, Liu X Abstract Endothelial dysfunction has an important role in the development and progression of salt-sensitive hypertension. Asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide synthase (NOS), has been demonstrated to be involved in the pathophysiological processes of endothelial dysfunction and salt‑sensitive hypertension. However, it is currently unclear how high salt intake may induce these processes. The present study investigated the effects of high salt medium on ADMA, endothelial NOS (eNOS) and the Ras homolog gene family, member A (RhoA)/R...
Source: Molecular Medicine Reports - May 15, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

TRIM59 is upregulated and promotes cell proliferation and migration in human osteosarcoma.
Authors: Liang J, Xing D, Li Z, Shen J, Zhao H, Li S Abstract Osteosarcoma is a prevalent type of cancer and has a high metastatic ability, particularly for metastasis to the lungs. Effective treatment strategies have improved, however, the detailed molecular mechanism underlying the onset of this malignancy remains to be fully elucidated. The current study investigated the role of the tripartite motif (TRIM) family protein TRIM59 in osteosarcoma growth and metastasis. It was identified that TRIM59 was overexpressed in clinical osteosarcoma tissues and cultured osteosarcoma cell lines. In addition, the MTT assay de...
Source: Molecular Medicine Reports - April 30, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

TLR2/NFκB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation.
In conclusion, the release of IL‑6 from MSCs was regulated via the TLR2/NFκB signalling pathway. Endogenous IL‑6 reduced apoptosis and protected OGD‑injured PC12 cells when they were co‑cultured with MSCs. The present study has reported a novel immunomodulatory effect of the microenvironment of neural damage during MSC cytotherapy. PMID: 27108485 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - April 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of versican V1 induces a severe inflammatory response in LPS-induced acute lung injury via the TLR2-NF-κB signaling pathway in C57BL/6J mice.
Authors: Xu L, Xue T, Zhang J, Qu J Abstract The versican family is important in the modulation of inflammation, however, the role of versican V1 (V1) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the underlying mechanisms remain to be elucidated. To investigate this, the present study performed experiments in male C57BL/6J mice, which were randomly divided into a normal control group (control; n=6), an LPS‑stimulated ALI group (LPS; n=6), a scramble small interfering (si)RNA group (scramble; n=6), a V1‑siRNA group (V1‑siRNA; n=6), a scramble siRNA and LPS‑stimulated group (scramble+LPS; n...
Source: Molecular Medicine Reports - April 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

DNase I aggravates islet β-cell apoptosis in type 2 diabetes.
Authors: Zhu B, Zhang L, Zhang YY, Wang L, Li XG, Liu T, Fu YK, Zheng YF, Li P, Zhao ZG Abstract Deoxyribonuclease I (DNase I) is an endonuclease responsible for the destruction of chromatin during apoptosis. However, its role in diabetes remains unclear. The aim of the current study was to investigate the role of DNase I combined with high glucose levels in β‑cell apoptosis. Human samples were collected and the DNase I activity was examined. High glucose‑cultured INS‑1 cells were transfected with DNase I small interfering RNA (siRNA) and the cell apoptosis was examined by western blotting and flow cyto...
Source: Molecular Medicine Reports - April 18, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells.
Authors: Liao YX, Zeng JM, Zhou JJ, Yang GH, Ding K, Zhang XJ Abstract Human bladder cancer is the most common urological malignancy in China. One of the causes of carcinogenesis in the cancer may be gene mutation. Therefore, the present study investigated the expression levels of Rhotekin 2 (RTKN2), a Rho effector protein, in human bladder cancer tissues and cell lines, and examined the effect of RTKN2 on the proliferation, cell cycle, apoptosis and invasion of human bladder cancer cell lines. The mRNA expression levels of RTKN2 in 30 human bladder cancer tissue samples were significantly higher, compared with t...
Source: Molecular Medicine Reports - April 18, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.
Authors: Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, Wu X, Fu X Abstract Lung epithelium restoration subsequent to injury is of concern in association with the outcomes of diverse inflammatory lung diseases. Previous studies have demonstrated that mesenchymal stem cells (MSCs) may promote epithelial repair subsequent to inflammatory injury, however the mechanism that mediates this effect remains unclear. The current study examined the role of MSCs in alveolar type II epithelial cell (AT‑II cell) restoration subsequent to an inflammatory insult. AT‑II cells were firstly exposed to inflammatory cytokines incl...
Source: Molecular Medicine Reports - April 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR‑19a‑3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion.
In conclusion, the findings of the present study suggest that the upregulation of miR‑19a‑3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. PMID: 27035427 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - April 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death.
Authors: Wu J, Chi L, Chen Z, Lu X, Xiao S, Zhang G, Luo J, Chen GM, Yang J Abstract The TMPRSS2:E‑twenty‑six (ETS) gene fusion occurs frequently in a high proportion of patients with prostate cancer (PCa) in Western countries, and the aberrant expression of TMPRSS2: v‑ETS avian erythroblastosis virus E26 oncogene homolog (ERG), the most common form of the corresponding protein, can regulate cell migration and contribute to tumor invasion and metastasis. However, its association with other cellular events, and in particular, cell death, remain unknown. To examine the function of such fusion genes, an expressi...
Source: Molecular Medicine Reports - March 6, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

β‑catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl‑xl.
Authors: Zhang J, Liu J, Li H, Wang J Abstract The Wnt/β‑catenin signaling pathway has been reported to regulate cisplatin resistance in several types of cancer cell. The present study aimed to investigate the role and underlying mechanism of Wnt/β‑catenin signaling in cisplatin resistance of lung adenocarcinoma cells. Wild‑type and cisplatin‑resistant A549 human lung adenocarcinoma cells (A549/WT and A549/CDDP, respectively) were cultured in vitro and exposed to different cisplatin concentrations. Cells were incubated with 10 mM lithium chloride (LiCl) to activate β‑catenin signaling. Cell prolifera...
Source: Molecular Medicine Reports - February 12, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase.
Authors: Guo Q, Liu Z, Jiang L, Liu M, Ma J, Yang C, Han L, Nan K, Liang X Abstract Metformin, the most widely administered oral anti‑diabetic therapeutic agent, exerts its glucose-lowering effect predominantly via liver kinase B1 (LKB1)-dependent activation of adenosine monophosphate-activated protein kinase (AMPK). Accumulating evidence has demonstrated that metformin possesses potential antitumor effects. However, whether the antitumor effect of metformin is via the LKB1/AMPK signaling pathway remains to be determined. In the current study, the effects of metformin on proliferation, cell cycle progression, and...
Source: Molecular Medicine Reports - February 9, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

NS‑398 promotes pancreatic cancer cell invasion by CD147 and MMP‑2 via the activation of P38.
Authors: Liu H, Xu XF, Zhao Y, Tang MC, Zhou YQ, Gao FH Abstract The overexpression or abnormal activation of cyclo‑oxygenase‑2 (COX‑2) has been reported in pancreatic cancer cells. NS‑398, a selective inhibitor of COX‑2, is unable to inhibit pancreatic cancer cell proliferation, as determined by a Cell Counting Kit 8 assay. However, it does increase cancer cell invasiveness, and therefore the invasiveness of the PANC‑1 cells was determined, along with the activation of P38, which was assessed by western blotting. In the present study, to evaluate the mechanisms underlying the action of NS‑398 in pan...
Source: Molecular Medicine Reports - January 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC‑7901 gastric cancer cells.
Authors: Xie C, Wang K, Chen D Abstract Flap endonuclease 1 (FEN1), which is key in DNA replication and repair, has been demonstrated to be intimately involved in the development and progression of cancer. Our previous study determined that the downregulation of FEN1 can suppress the proliferation of, and induce apoptosis in, gastric cancer SGC‑7901 cells. In addition, several FEN1 inhibitors have been identified to increase sensitisation to DNA injury agents. These results may provide a promising treatment method to enhance the traditional chemotherapeutics used for the treatment of gastric cancer. Thus, the aim...
Source: Molecular Medicine Reports - January 16, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Gene silencing of galectin-3 changes the biological behavior of Eca109 human esophageal cancer cells.
In conclusion, following successful knockdown of galecin-3 expression in Eca109 cells, the cell proliferation, migration and invasion were reduced, while the apoptosis was enhanced, which indicates that galectin silencing may represent a therapeutic strategy for EC. PMID: 26718452 [PubMed - in process]
Source: Molecular Medicine Reports - January 16, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research