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Source: Molecular Medicine Reports
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Total 308 results found since Jan 2013.
Lentiviral ‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling.
Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling.
Mol Med Rep. 2019 Jul 31;:
Authors: Jiang ZL, Jin H, Liu ZS, Liu MY, Cao XF, Jiang YY, Bai HD, Zhang B, Li Y
Abstract
Patients with diabetes tend to have an increased incidence of osteoporosis, which may be associated with hyperglycemia; however, the pathogenic mechanisms governing this interaction remain unknown. The present study sought to investigate whether elevated extracellular glucose levels of bone mesenchymal stem cells (BMSCs) could influence ...
Source: Molecular Medicine Reports - August 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC ‑SD cells.
In conclusion, the present study showed that the expression and protein levels of MPZL1 were significantly higher in gallbladder carcinoma tissues, especially in patients diagnosed with advanced tumor stages. Overexpression of MPZL1 may have promoted the invasion, metastasis, proliferation and survival of GBC‑SD cells.
PMID: 31322261 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 21, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Corrigendum Knockdown of lncRNA Â HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma.
[Corrigendum] Knockdown of lncRNAÂ HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma.
Mol Med Rep. 2019 Jun 11;:
Authors: Zhu W, Zhuang P, Song W, Duan S, Xu Q, Peng M, Zhou J
Abstract
Following the publication of the article, the authors noted an error associated with the presentation of Fig. 3B. This Figure part showed the cell cycle analysis as determined by flow cytometry of HT29 cells transfected with either a HNF1A-AS1-specific siRNA or a negative control siRNA at 48 h post-transfection. An error was made in the compilation of this Figure, and the same data were inadvertently sel...
Source: Molecular Medicine Reports - July 2, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway.
Authors: Zhang C, Yu Y, Huang Q, Tang K
Abstract
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and exhibits a high mortality rate. Sirtuin (SIRT)6 is a member of the sirtuin family, which may be useful targets in the treatment of tumors. The present study aimed to explore the expression of SIRT6 in numerous HCC cell lines and investigate the role of SIRT6 in the proliferation and apoptosis of the HCC cells, and the underlying mechanisms. Overexpression and silencing of SIRT6 were performed by transfection of Huh‑7 cells with synthetic overexpression and small interfering RNA (siRNA) pl...
Source: Molecular Medicine Reports - July 2, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxin ‑induced acute kidney injury.
RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxin‑induced acute kidney injury.
Mol Med Rep. 2019 Jun 24;:
Authors: Zhang S, Li R, Dong W, Yang H, Zhang L, Chen Y, Wang W, Li C, Wu Y, Ye Z, Zhao X, Li Z, Zhang M, Liu S, Liang X
Abstract
Renal tubular epithelial cell apoptosis is an important pathological mechanism of septic acute kidney injury (AKI). Endotoxin, also known as lipopolysaccharide (LPS), has a key role in septic AKI and can directly induce tubular epithelial cell apoptosis. The upregulation of receptor‑interacting protein kinase 3 (RIPK3) in tubular epithelial cells ha...
Source: Molecular Medicine Reports - July 2, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Inhibition of p53 alleviates prostate cell apoptosis in Escherichia  coli‑induced bacterial prostatitis.
Inhibition of p53 alleviates prostate cell apoptosis in Escherichia coli‑induced bacterial prostatitis.
Mol Med Rep. 2019 Jun 06;:
Authors: Wang H, Ji Z
Abstract
Previous studies demonstrated that uropathogenic Escherichia coli infection contributes to human bacterial prostatitis. Apoptosis of prostate epithelial cells is closely associated with the progression of bacterial prostatitis. The aim of the present study was to investigate the effect of cellular tumor antigen p53 (p53) on the apoptosis of bacterial prostatitis cells. The prostate epithelial RWPE‑1 cell line was infected with Escherich...
Source: Molecular Medicine Reports - June 9, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
p53 mediates PEDF ‑induced autophagy in human umbilical vein endothelial cells through sestrin2 signaling.
p53 mediates PEDF‑induced autophagy in human umbilical vein endothelial cells through sestrin2 signaling.
Mol Med Rep. 2019 Jun 03;:
Authors: Chen T, Li T, Wang J
Abstract
Autophagy is a conserved catabolic process by which cytoplasmic components are delivered into lysosomes for degradation. Pigment epithelium‑derived factor (PEDF) has been reported to be associated with autophagy and can induce p53 expression; however, the mechanism relating PEDF with autophagy in endothelial cells remains poorly understood. The present study aimed to investigate the association between the PEDF‑p53‑sestrin pa...
Source: Molecular Medicine Reports - June 9, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.
Authors: Ji QK, Ma JW, Liu RH, Li XS, Shen FZ, Huang LY, Hui L, Ma YJ, Jin BZ
Abstract
Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, recently identified as a target gene of c‑Myc and is frequently dysregulated in multiple cancers. However, to the best of our knowledge, no studies to date have been carried out to investigate the functions of CDCA7L in glioma. Thus, in this study, the expression level of CDCA7L and its association with the prognosis in glioma were detected through the TCGA database. The mRNA expression levels of CDCA7L in glioblastoma (GBM) tissues and normal bra...
Source: Molecular Medicine Reports - June 9, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in  vitro.
AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro.
Mol Med Rep. 2019 Jun 05;:
Authors: He R, Han W, Hu Y, Chen X, Hu X, Zhu Y
Abstract
17β‑estradiol (E2) and aquaporin 2 (AQP2) are associated with endometrial receptivity, and E2 directly regulates AQP2 expression in endometrial cancer cells. The present study aimed to investigate the role of AQP2 in embryo implantation. Normal endometrial samples were collected at the Women's Hospital (Hangzhou, China) from women seeking in vitro fertilization and embryo transfer; women with endometrial abnorma...
Source: Molecular Medicine Reports - June 9, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation ‑induced injury of H9c2 cardiomyocytes.
Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation‑induced injury of H9c2 cardiomyocytes.
Mol Med Rep. 2019 May 09;:
Authors: Guan G, Yang L, Huang W, Zhang J, Zhang P, Yu H, Liu S, Gu X
Abstract
Endoplasmic reticulum (ER) stress and autophagy are involved in myocardial ischemia‑reperfusion (I/R) injury; however, their roles in this type of injury remain unclear. The present study investigated the roles of ER stress and autophagy, and their underlying mechanisms, in H9c2 cells during hypoxia/reoxygenation (H/R) injury. Cell viability was detected b...
Source: Molecular Medicine Reports - May 23, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MicroRNA ‑214 upregulates HIF‑1α and VEGF by targeting ING4 in lung cancer cells.
In conclusion, it was demonstrated that miR‑214 targeted ING4 in lung cancer cells, and upregulated the HIF‑1α cascade, leading to MMP2 and VEGF upregulation. This approach may help to clarify the role of miRNA in non‑small lung cancer and may be a new therapeutic target for non‑small lung cancer.
PMID: 31059086 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - May 8, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Downregulation of microRNA ‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.
Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.
Mol Med Rep. 2019 Apr 25;:
Authors: Liu DW, Zhang YN, Hu HJ, Zhang PQ, Cui W
Abstract
MicroRNAs (miRs) have been identified as critical regulatory molecules in myocardial ischemia/reperfusion injury; however, the exact expression profile of miR‑199a‑5p in reperfusion injury and the underlying pathogenic mechanisms remain unclear. In the present study, it was revealed that miR‑199a‑5p expression was significantly increased in the plasma...
Source: Molecular Medicine Reports - May 8, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Role of feline sarcoma ‑related protein in the viability and apoptosis of bladder cancer cells.
Role of feline sarcoma‑related protein in the viability and apoptosis of bladder cancer cells.
Mol Med Rep. 2019 Apr 30;:
Authors: Hu X, Guo Z, Xu J, Mei X, Bi M, Jiang F, Yu D, Zhong C
Abstract
Feline sarcoma‑related protein (Fer) is a type of nuclear and cytoplasmic non‑receptor protein tyrosine kinase, which is associated with the progression of numerous types of cancer. Previously, we identified that Fer is associated with the migration and invasion of bladder cancer. The present study aimed to investigate the role of Fer in bladder cancer cell viability and apoptosis. Reverse transcriptionâ€...
Source: Molecular Medicine Reports - May 8, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis.
Authors: Cui C, Wang X, Shang XM, Li L, Ma Y, Zhao GY, Song YX, Geng XB, Zhao BQ, Tian MR, Wang HL
Abstract
The proliferation and migration of vascular smooth muscle cells (VSMCs) are major cellular events in hypertension‑induced vascular remodeling, which is closely involved in the progression of atherosclerosis (AS). Although long non‑coding RNAs (lncRNAs) are gaining recognition as novel regulators of VSMCs, their functioning and role in AS remain to be elucidated. In the present study, the role of lncRNA ENST00000430945 (lncRNA 430945) in AS was investigated. VSMCs transfected with a small interfering RNA (...
Source: Molecular Medicine Reports - April 9, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial ‑mesenchymal transition.
FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition.
Mol Med Rep. 2019 Mar 27;:
Authors: Luo YD, Ding X, Du HM, Wu YN, Li HQ, Wu HM, Zhang XM
Abstract
Although forkhead box protein M1 (FOXM1) is markedly upregulated in human premalignant and oral squamous cell carcinoma (OSCC) tissues and cultured cells, the association of FOXM1 expression with OSCC prognosis is not well understood. The present study investigated the possible association of FOXM1 expression in patients with OSCC with their clinicopatho...
Source: Molecular Medicine Reports - April 5, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
