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Source: Molecular Medicine Reports

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Total 308 results found since Jan 2013.

Induction of Huh ‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway.
Induction of Huh‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway. Mol Med Rep. 2018 Apr 05;: Authors: Shen S, Li C, Dai M, Yan X Abstract Hepatitis C virus (HCV)‑infected liver cells sensitize host cells to tumor necrosis factor (TNF)‑related apoptosis‑inducing ligand (TRAIL)‑induced cell apoptosis; however, the precise mechanisms are unknown. In the present study, flow cytometry demonstrated that the Annexin V‑positive Huh‑7 cell number was higher in groups transfected with core proteins when compared with the pcDNA3.1 group. The mRNA and protein expression...
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Dysregulation of PTEN caused by the underexpression of microRNA ‑130b is associated with the severity of lupus nephritis.
Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis. Mol Med Rep. 2018 Apr 03;: Authors: Wu S, Wang J, Li F Abstract There are several reports in the literature regarding microRNA (miR)‑130b. It has been reported that miR‑130b is involved in several diseases. The present study aimed to understand the association between the levels of miR‑130b and lupus nephritis in patients. A total of 61 blood samples were collected and the expression level of miR‑130b was determined. The online miRNA database was then searched using the 'se...
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibition of DNA ‑PK activity sensitizes A549 cells to X‑ray irradiation by inducing the ATM‑dependent DNA damage response.
In conclusion, inhibition of DNA‑PK activity increased the radiosensitivity of A549 cells to X‑ray irradiation. NU7026 treatment activated the ATM‑dependent DNA damage response and induced p73 apoptosis pathway. DNA‑PK inhibitor may be an effective constituent of radiosensitization products. DNA damage repair pathway could be a potential target for radiosensitization. PMID: 29620203 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.
Authors: Zhu J, Ren J, Tang L Abstract Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of genistein on Wnt inhibitory factor 1 (WIF1) and invasion, and migration of colon cancer cells. The viability of HT29 colon cancer cells was suppressed by genistein in a dose dependent manner. Following 72 h of treatment with 10, 20 and 60 µmol/l genistein, incre...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulation of lncRNA H19 inhibits migration and invasion of human osteosarcoma through the NF- κB pathway.
Downregulation of lncRNA H19 inhibits migration and invasion of human osteosarcoma through the NF-κB pathway. Mol Med Rep. 2018 Mar 14;: Authors: Zhao J, Ma ST Abstract The present study aimed to investigate the role of long non-coding RNA (lncRNA) H19 in the development of osteosarcoma and to determine the underlying mechanism involved. A total of 40 patients with osteosarcoma were selected and the expression level of H19 in tumor tissue and adjacent healthy tissue was detected by reverse transcription‑quantitative polymerase chain reaction. Survival curves were plotted using the Kaplan‑Meier me...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Upregulated plasmacytoma variant translocation 1 promotes cell proliferation, invasion and metastasis in colorectal cancer.
Authors: Wang C, Zhu X, Pu C, Song X Abstract Emerging evidence indicates that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) is associated with tumourigenesis in various types of cancer. However, its specific effects on the proliferation, invasion and metastasis of colorectal cancer (CRC) are still poorly understood. The present study aimed to investigate PVT1 expression in CRC and explore its role in CRC pathogenesis. The reverse transcriptase‑quantitative polymerase chain reaction (RT‑qPCR) technique was used to assess PVT1 expression in CRC cell lines. Gene Expression Omnibus ...
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of ZEB1 suppressed the formation of vasculogenic mimicry and epithelial-mesenchymal transition in the human breast cancer cell line MDA-MB-231.
Authors: Liang W, Song S, Xu Y, Li H, Liu H Abstract Breast cancer is a common malignant tumor in women. It has been suggested that a type of microcirculation pattern that does not rely on host microvascular endothelial cells known as vasculogenic mimicry (VM) may contribute to the poor effect of anti‑angiogenesis treatment on some patients with breast cancer. However, the formation and regulatory mechanism of VM in breast cancer are unclear and still require further investigation. The present study examined whether decreasing the expression of zinc finger E‑box binding homeobox (ZEB1) using siRNA can inhibit t...
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells.
In conclusion, the present study demonstrated that targeting autophagy may be used in the future for the treatment of lung cancer. PMID: 29512762 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

HIF-1-mediated expression of Foxo1 serves an important role in the proliferation and apoptosis of osteoblasts derived from children's iliac cancellous bone.
Authors: Xu G Abstract Activation of the transcription factor hypoxia inducible factor‑1α (HIF-1α) is considered critical for the stimulation of osteogenic markers including runt‑related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin, which are closely associated with forkhead boxclass O1 (Foxo1) levels in osteoblasts. The present study explored the associations between HIF‑1α and Foxo1 in the regulation of cell viability, proliferation and apoptosis of osteoblasts. Osteoblasts obtained from children's iliac cancellous bone were used in the present study, which were confirmed b...
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Pre-B cell leukemia transcription factor 3 induces inflammatory responses in human umbilical vein endothelial cells and murine sepsis via acting a competing endogenous RNA for high mobility group box 1 protein.
Authors: Zhang Y, Feng J, Cui J, Yang G, Zhu X Abstract The present study investigated the roles of pre-B cell leukemia transcription factor 3 (PBX3) in sepsis. Reverse transcription-quantitative polymerase chain reaction and western blot analysis indicated that overexpression of the PBX 3'‑untranslated region (UTR) promoted high mobility group box 1 (HMGB1) protein expression in human umbilical vein endothelial cells (HUVECs) (P<0.01). Furthermore, post‑treatment of PBX3 small interfering (si)RNA suppressed lipopolysaccharide (LPS)‑mediated HMGB1 release and attenuated HMGB1‑mediated hyperpermeability a...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2 α attenuates focal ischemic brain damage in mice.
Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2α attenuates focal ischemic brain damage in mice. Mol Med Rep. 2018 Feb 15;: Authors: Wu H, Liu H, Zuo F, Zhang L Abstract Cerebral ischemia injury is a clinical, frequently occurring disease, which causes a heavy burden on society and families. It has been demonstrated that cytosolic phospholipase A2α (cPLA2α) is significant in neurological injury caused by ischemic brain injury, and inhibition of cPLA2α may reduce stroke injury. In the present study, the role of cPLA2α was investigated in a mouse model of middle cerebral...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Cartilage intermediate layer protein is regulated by mechanical stress and affects extracellular matrix synthesis.
In conclusion, these results demonstrated for the first time, to the best of our knowledge, that in human NP cells, CILP is regulated by mechanical stress and that its expression affects ECM synthesis. Therefore, CILP represents a promising therapeutic target for preventing loss of the matrix during IDD as a novel treatment strategy. PMID: 29436660 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - February 14, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Curcumin increases cholesterol efflux via heme oxygenase ‑1‑mediated ABCA1 and SR‑BI expression in macrophages.
Curcumin increases cholesterol efflux via heme oxygenase‑1‑mediated ABCA1 and SR‑BI expression in macrophages. Mol Med Rep. 2018 Feb 08;: Authors: Zhong Y, Feng J, Fan Z, Li J Abstract Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages were treated with different concentrations of curcumin, HO‑1 inhibitor and small interfering ...
Source: Molecular Medicine Reports - February 14, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Expression of immunoglobulin A in human mesangial cells and its effects on cell apoptosis and adhesion.
Authors: Deng H, Ma J, Jing Z, Deng Z, Liang Y, A L, Liu Y, Qiu X, Wang Y Abstract IgA nephropathy (IgAN) is characterized by predominant IgA deposition in the glomerular mesangium. It has been considered that the deposited IgA is synthesized by B cells, although recent reports have suggested the implication of other cell types. Therefore, the present study investigated whether glomerular mesangial cells could produce IgA by themselves. Semi‑quantitative reverse transcription-polymerase chain reaction, and immunostaining analysis revealed that the IgA protein and gene transcripts were expressed in primary human r...
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of cullin  4B on the proliferation and invasion of human gastric cancer cells.
Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells. Mol Med Rep. 2018 Jan 26;: Authors: He F, Cheng XM, Gu WL Abstract The major aim of the present study was to explore the effects of cullin 4B (CUL4B) on the proliferation and invasion of human gastric cancer cells. Gastric tumor tissues and paired adjacent non‑tumor tissues were obtained from 21 gastric cancer patients, and gastric cancer cell lines (AGS, MGC‑803, KATO‑III, MKN‑45, SGC‑7901, BGC‑823 and MKN‑74) were cultured. BGC‑823 cells were transfected with CUL4B small interfering (si)RNA or con...
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research