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Source: Experimental Cell Research
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Total 221 results found since Jan 2013.
Inhibition of TRPC6 suppressed TGF β-induced fibroblast-myofibroblast transdifferentiation in renal interstitial NRK-49F cells
In conclusion, we demonstrate that TRPC6 is a key regulator of TGF-β1-induced fibroblast-myofibroblast transdifferentiation and provides the mechanism of how TGF-β1 exposure regulates TRPC6 expression in NRK-49F fibroblasts.PMID:36206825 | DOI:10.1016/j.yexcr.2022.113374
Source: Experimental Cell Research - October 7, 2022 Category: Cytology Authors: Shan Jiang Lifei Gu Yixin Hu Younan Ren Zhao Yang Chengzhi Chai Boyang Yu Haitao Ge Zhengyu Cao Fang Zhao Source Type: research
Ectodysplasin-A mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response
CONCLUSIONS: HSC activation leads to altered EXO mRNA/miRNA profiles with aHSC-EXOs mRNAs exerting a dominant role in altering macrophage function. Ectodysplasin-A mRNA is an important component in aHSC-EXOs in regulating macrophage function.PMID:35964664 | DOI:10.1016/j.yexcr.2022.113297
Source: Experimental Cell Research - August 14, 2022 Category: Cytology Authors: Emilio Marrero Neha Attal Ali Nimeri Rachel M McGee Jennifer H Benbow Kyle J Thompson Laura W Schrum Iain H McKillop Source Type: research
CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1
Exp Cell Res. 2022 Jul 7:113279. doi: 10.1016/j.yexcr.2022.113279. Online ahead of print.ABSTRACTCholesterol homeostasis plays an important role in the maintenance of normal body functions. CYP27A1 is a key enzyme known to regulate cholesterol homeostasis, which catalyzes the conversion of cholesterol to 27-HC and has been implicated in the occurrence and metastasis of various cancer types. The present study aimed to explore the regulatory role of CYP27A1 in the development of clear cell renal cell carcinoma (ccRCC). In particular, the effect of CYP27A1 on the proliferation and migration of ccRCC cells was investigated. Th...
Source: Experimental Cell Research - July 10, 2022 Category: Cytology Authors: Zhijuan Liang Wei Jiao Liping Wang Yuanbin Chen Dan Li Zhao Zhang Zhilei Zhang Ye Liang Haitao Niu Source Type: research
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway
Exp Cell Res. 2022 Apr 26:113179. doi: 10.1016/j.yexcr.2022.113179. Online ahead of print.ABSTRACTRab22a, a member of the proto-oncogene RAS family, belongs to the Rab5 subfamily. It participates in early endosome formation and regulates vesicle trafficking. The relationship between Rab22a and tumorigenesis remains elusive. In non-small cell lung cancer specimens, immunohistochemical staining showed consistently high expression of Rab22a in lung adenocarcinoma, but not in squamous cell carcinoma. In lung adenocarcinoma cell lines, A549 and H1299, transfection with Rab22a significantly promoted cell proliferation, migration...
Source: Experimental Cell Research - April 29, 2022 Category: Cytology Authors: Jinping Wang Xue Luo Jinxi Lu Xi Wang Yuan Miao Qingchang Li Liang Wang Source Type: research
Disruption of the CCDC43-FHL1 interaction triggers apoptosis in gastric cancer cells
Exp Cell Res. 2022 Mar 16:113107. doi: 10.1016/j.yexcr.2022.113107. Online ahead of print.ABSTRACTThe coiled-coil domain-containing protein 43 (CCDC43) is essential to promote gastric cancer (GC) proliferation and invasion, while four and a half LIM domains 1 (FHL1) involves GC cells apoptosis. We attempted to address inter-relationship between CCDC43 and FHL1 in modulating GC cells growth and apoptosis. Levels of protein expression were assessed by western blot, immunofluorescence. Using EdU, plate colony formation, Matrigel invasion and animal models, we evaluated the function in vitro and in vivo. Apoptosis was evaluate...
Source: Experimental Cell Research - March 20, 2022 Category: Cytology Authors: Yaying Chen Miaomiao Pei Jiaying Li Zhi Wang Side Liu Li Xiang Jieming Zhang Linjie Hong Jianjiao Lin Weiyu Dai Yizhi Xiao Hongsong Hu Weimei Tang Guangnan Liu Qiong Yang Zhizhao Lin Xiaoling Jiang Yusi Wang Xiaosheng Wu Zheng Guo Jide Wang Source Type: research
Semaphorin 3E promote Schwann cell proliferation and migration
This study indicated that Sema3E promoted SC proliferation and migration and the involvement of receptor PlexinD1, Nrp1, and VEGFR2 in these processes. This study extended our understanding of the mechanism that modulated SC phenotype during nerve injury and provided a potential target for promoting PN regeneration.PMID:35085549 | DOI:10.1016/j.yexcr.2022.113019
Source: Experimental Cell Research - January 27, 2022 Category: Cytology Authors: Mi Shen Yuhan Chen Wei Tang Mengru Ming Yingchao Tian Fei Ding Han Wu Yuhua Ji Source Type: research
Cxcl10 deficiency attenuates renal interstitial fibrosis through regulating epithelial-to-mesenchymal transition
In this study, Cxcl10-deficient (Cxcl10-/-) mice were used to generate the unilateral ureteral obstruction (UUO) model. The level of renal fibrosis and inflammatory cell infiltration was examined in vivo and the effects of CXCL10 on EMT process of HK-2 cells was investigated in vitro. We observed that the injury degree of renal tissue and the collagen deposition levels were lighter and the expression of α-SMA, collagen I and fibronectin was significantly reduced in Cxcl10-/- mice. However, interstitial F4/80-positive macrophages and CD4-positive T lymphocytes were unaffected by knockout of Cxcl10. Furthermore, IFN-γ or...
Source: Experimental Cell Research - December 13, 2021 Category: Cytology Authors: Jie Gao Lingling Wu Yinghua Zhao Quan Hong Zhe Feng Xiangmei Chen Source Type: research
Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells
In conclusion, targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer may be a novel therapeutic option.PMID:34808132 | DOI:10.1016/j.yexcr.2021.112940
Source: Experimental Cell Research - November 22, 2021 Category: Cytology Authors: Nozomu Nakagawa Noriko Miyake Nobuaki Ochi Hiromichi Yamane Masami Takeyama Yasunari Nagasaki Tomoko Ikeda Etsuko Yokota Takuya Fukazawa Hidekazu Nakanishi Daijiro Harada Katsuyuki Kiura Nagio Takigawa Source Type: research
MUSTN1 is an indispensable factor in the proliferation, differentiation and apoptosis of skeletal muscle satellite cells in chicken
Exp Cell Res. 2021 Sep 16;407(2):112833. doi: 10.1016/j.yexcr.2021.112833. Online ahead of print.ABSTRACTThe yield and quality of the skeletal muscle are important economic traits in livestock and poultry production. The musculoskeletal embryonic nuclear protein 1 (MUSTN1) gene has been shown to be associated with embryonic development, postnatal growth, bone and skeletal muscle regeneration; however, its function in the skeletal muscle development of chicken remains unclear. Therefore, in this study, we observed that the expression level of MUSTN1 increased in conjunction with the proliferation of chicken skeletal muscle ...
Source: Experimental Cell Research - September 18, 2021 Category: Cytology Authors: Zhi Hu Hengyong Xu Yuxiang Lu Qijian He Chaoyang Yan Xiaoling Zhao Yaofu Tian Chaowu Yang Zengrong Zhang Mohan Qiu Yan Wang Source Type: research
